Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States.

Wieczorek, Lindsay; Sanders-Buell, Eric; Zemil, Michelle; Lewitus, Eric; Kavusak, Erin; Heller, Jonah; Molnar, Sebastian; Rao, Mekhala; Smith, Gabriel; Bose, Meera; Nguyen, Amy; Dhungana, Adwitiya; Okada, Katherine; Parisi, Kelly; Silas, Daniel; Slike, Bonnie; Ganesan, Anuradha; Okulicz, Jason; Lalani, Tahaniyat; Agan, Brian K; Crowell, Trevor A; Darden, Janice; Rolland, Morgane; Vasan, Sandhya; Ake, Julie; Krebs, Shelly J; Peel, Sheila; Tovanabutra, Sodsai; Polonis, Victoria R.

PLoS Pathog ; 19(12): e1011780, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38055771

2.

HIV-1 infections with multiple founders associate with the development of neutralization breadth.

Lewitus, Eric; Townsley, Samantha M; Li, Yifan; Donofrio, Gina C; Dearlove, Bethany L; Bai, Hongjun; Sanders-Buell, Eric; O'Sullivan, Anne Marie; Bose, Meera; Kibuuka, Hannah; Maganga, Lucas; Nitayaphan, Sorachai; Sawe, Fredrick K; Eller, Leigh Anne; Michael, Nelson L; Polonis, Victoria R; Ake, Julie A; Vasan, Sandhya; Robb, Merlin L; Tovanabutra, Sodsai; Krebs, Shelly J; Rolland, Morgane.

PLoS Pathog ; 18(3): e1010369, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35303045

3.

Optimal sequence-based design for multi-antigen HIV-1 vaccines using minimally distant antigens.

Lewitus, Eric; Hoang, Jennifer; Li, Yifan; Bai, Hongjun; Rolland, Morgane.

PLoS Comput Biol ; 18(10): e1010624, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36315492

4.

A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants.

Dearlove, Bethany; Lewitus, Eric; Bai, Hongjun; Li, Yifan; Reeves, Daniel B; Joyce, M Gordon; Scott, Paul T; Amare, Mihret F; Vasan, Sandhya; Michael, Nelson L; Modjarrad, Kayvon; Rolland, Morgane.

Proc Natl Acad Sci U S A ; 117(38): 23652-23662, 2020 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-32868447

5.

Molecular dating and viral load growth rates suggested that the eclipse phase lasted about a week in HIV-1 infected adults in East Africa and Thailand.

Rolland, Morgane; Tovanabutra, Sodsai; Dearlove, Bethany; Li, Yifan; Owen, Christopher L; Lewitus, Eric; Sanders-Buell, Eric; Bose, Meera; O'Sullivan, AnneMarie; Rossenkhan, Raabya; Labuschagne, Jan Phillipus Lourens; Edlefsen, Paul T; Reeves, Daniel B; Kijak, Gustavo; Miller, Shana; Poltavee, Kultida; Lee, Jenica; Bonar, Lydia; Harbolick, Elizabeth; Ahani, Bahar; Pham, Phuc; Kibuuka, Hannah; Maganga, Lucas; Nitayaphan, Sorachai; Sawe, Fred K; Eller, Leigh Anne; Gramzinski, Robert; Kim, Jerome H; Michael, Nelson L; Robb, Merlin L.

PLoS Pathog ; 16(2): e1008179, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-32027734

6.

Factors influencing estimates of HIV-1 infection timing using BEAST.

Dearlove, Bethany; Tovanabutra, Sodsai; Owen, Christopher L; Lewitus, Eric; Li, Yifan; Sanders-Buell, Eric; Bose, Meera; O'Sullivan, Anne-Marie; Kijak, Gustavo; Miller, Shana; Poltavee, Kultida; Lee, Jenica; Bonar, Lydia; Harbolick, Elizabeth; Ahani, Bahar; Pham, Phuc; Kibuuka, Hannah; Maganga, Lucas; Nitayaphan, Sorachai; Sawe, Fred K; Kim, Jerome H; Eller, Leigh Anne; Vasan, Sandhya; Gramzinski, Robert; Michael, Nelson L; Robb, Merlin L; Rolland, Morgane.

PLoS Comput Biol ; 17(2): e1008537, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33524022

7.

Characterizing and Comparing Phylogenetic Trait Data from Their Normalized Laplacian Spectrum.

Lewitus, Eric; Aristide, Leandro; Morlon, Hélène.

Syst Biol ; 69(2): 234-248, 2020 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-31529071

8.

Detecting Environment-Dependent Diversification From Phylogenies: A Simulation Study and Some Empirical Illustrations.

Lewitus, Eric; Morlon, Hélène.

Syst Biol ; 67(4): 576-593, 2018 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-29272547

9.

Natural Constraints to Species Diversification.

Lewitus, Eric; Morlon, Hélène.

PLoS Biol ; 14(8): e1002532, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27505866

10.

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Camp, J Gray; Badsha, Farhath; Florio, Marta; Kanton, Sabina; Gerber, Tobias; Wilsch-Bräuninger, Michaela; Lewitus, Eric; Sykes, Alex; Hevers, Wulf; Lancaster, Madeline; Knoblich, Juergen A; Lachmann, Robert; Pääbo, Svante; Huttner, Wieland B; Treutlein, Barbara.

Proc Natl Acad Sci U S A ; 112(51): 15672-7, 2015 Dec 22.

Artigo em Inglês | MEDLINE | ID: mdl-26644564

11.

Characterizing and Comparing Phylogenies from their Laplacian Spectrum.

Lewitus, Eric; Morlon, Helene.

Syst Biol ; 65(3): 495-507, 2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-26658901

12.

An adaptive threshold in mammalian neocortical evolution.

Lewitus, Eric; Kelava, Iva; Kalinka, Alex T; Tomancak, Pavel; Huttner, Wieland B.

PLoS Biol ; 12(11): e1002000, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25405475

13.

HIV-1 Gag, Pol, and Env diversified with limited adaptation since the 1980s.

Lewitus, Eric; Li, Yifan; Bai, Hongjun; Pham, Phuc; Rolland, Morgane.

mBio ; 15(3): e0174923, 2024 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-38329340

14.

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding.

Bai, Hongjun; Lewitus, Eric; Li, Yifan; Thomas, Paul V; Zemil, Michelle; Merbah, Mélanie; Peterson, Caroline E; Thuraisamy, Thujitha; Rees, Phyllis A; Hajduczki, Agnes; Dussupt, Vincent; Slike, Bonnie; Mendez-Rivera, Letzibeth; Schmid, Annika; Kavusak, Erin; Rao, Mekhala; Smith, Gabriel; Frey, Jessica; Sims, Alicea; Wieczorek, Lindsay; Polonis, Victoria; Krebs, Shelly J; Ake, Julie A; Vasan, Sandhya; Bolton, Diane L; Joyce, M Gordon; Townsley, Samantha; Rolland, Morgane.

Nat Commun ; 15(1): 3924, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38724518

15.

Design of a pan-betacoronavirus vaccine candidate through a phylogenetically informed approach.

Lewitus, Eric; Bai, Hongjun; Rolland, Morgane.

Sci Adv ; 9(3): eabq4149, 2023 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-36652518

16.

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity.

Chen, Wei-Hung; Hajduczki, Agnes; Martinez, Elizabeth J; Bai, Hongjun; Matz, Hanover; Hill, Thomas M; Lewitus, Eric; Chang, William C; Dawit, Layla; Peterson, Caroline E; Rees, Phyllis A; Ajayi, Adelola B; Golub, Emily S; Swafford, Isabella; Dussupt, Vincent; David, Sapna; Mayer, Sandra V; Soman, Sandrine; Kuklis, Caitlin; Corbitt, Courtney; King, Jocelyn; Choe, Misook; Sankhala, Rajeshwer S; Thomas, Paul V; Zemil, Michelle; Wieczorek, Lindsay; Hart, Tricia; Duso, Debora; Kummer, Larry; Yan, Lianying; Sterling, Spencer L; Laing, Eric D; Broder, Christopher C; Williams, Jazmean K; Davidson, Edgar; Doranz, Benjamin J; Krebs, Shelly J; Polonis, Victoria R; Paquin-Proulx, Dominic; Rolland, Morgane; Reiley, William W; Gromowski, Gregory D; Modjarrad, Kayvon; Dooley, Helen; Joyce, M Gordon.

Nat Commun ; 14(1): 580, 2023 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-36737435

17.

Does HIV-1 virulence matter in the ART era?

Lewitus, Eric; Rolland, Morgane.

Med ; 3(4): 217-219, 2022 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-35590149

18.

Our robust intellect.

Kalinka, Alex T; Kelava, Iva; Lewitus, Eric.

Trends Genet ; 29(3): 125-7, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23419455

19.

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1.

Shangguan, Shida; Ehrenberg, Philip K; Geretz, Aviva; Yum, Lauren; Kundu, Gautam; May, Kelly; Fourati, Slim; Nganou-Makamdop, Krystelle; Williams, LaTonya D; Sawant, Sheetal; Lewitus, Eric; Pitisuttithum, Punnee; Nitayaphan, Sorachai; Chariyalertsak, Suwat; Rerks-Ngarm, Supachai; Rolland, Morgane; Douek, Daniel C; Gilbert, Peter; Tomaras, Georgia D; Michael, Nelson L; Vasan, Sandhya; Thomas, Rasmi.

Elife ; 102021 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-34533134

20.

RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection.

Lewitus, Eric; Sanders-Buell, Eric; Bose, Meera; O'Sullivan, Anne Marie; Poltavee, Kultida; Li, Yifan; Bai, Hongjun; Mdluli, Thembi; Donofrio, Gina; Slike, Bonnie; Zhao, Hong; Wong, Kim; Chen, Lennie; Miller, Shana; Lee, Jenica; Ahani, Bahar; Lepore, Steven; Muhammad, Sevan; Grande, Rebecca; Tran, Ursula; Dussupt, Vincent; Mendez-Rivera, Letzibeth; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Rerks-Ngarm, Supachai; O'Connell, Robert J; Janes, Holly; Gilbert, Peter B; Gramzinski, Robert; Vasan, Sandhya; Robb, Merlin L; Michael, Nelson L; Krebs, Shelly J; Herbeck, Joshua T; Edlefsen, Paul T; Mullins, James I; Kim, Jerome H; Tovanabutra, Sodsai; Rolland, Morgane.

Virus Evol ; 7(2): veab057, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34532060

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