Detalhe da pesquisa
1.
HSP90ß prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
Proc Natl Acad Sci U S A
; 120(31): e2221522120, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37487085
2.
The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage.
J Neuroinflammation
; 20(1): 119, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217935
3.
Light damage induces inflammatory factors in mouse retina and vitreous humor.
Mol Vis
; 29: 180-187, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38222454
4.
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes.
Proc Natl Acad Sci U S A
; 115(17): E3987-E3995, 2018 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29622681
5.
Sumoylation differentially regulates Sp1 to control cell differentiation.
Proc Natl Acad Sci U S A
; 111(15): 5574-9, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24706897
6.
HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
Biochim Biophys Acta
; 1853(8): 1808-17, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25940838
7.
HSF4 regulates DLAD expression and promotes lens de-nucleation.
Biochim Biophys Acta
; 1832(8): 1167-72, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23507146
8.
HSF4 is involved in DNA damage repair through regulation of Rad51.
Biochim Biophys Acta
; 1822(8): 1308-15, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22587838
9.
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.
Proc Natl Acad Sci U S A
; 107(49): 21034-9, 2010 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21084637
10.
The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens.
Prog Retin Eye Res
; 92: 101112, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36055924
11.
ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.
Cells
; 12(22)2023 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37998373
12.
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.
Aging (Albany NY)
; 15(17): 8812-8832, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683133
13.
MAB21L1 promotes survival of lens epithelial cells through control of αB-crystallin and ATR/CHK1/p53 pathway.
Aging (Albany NY)
; 14(15): 6128-6148, 2022 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35951367
14.
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response.
Cells
; 11(9)2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35563857
15.
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration.
Free Radic Biol Med
; 178: 147-160, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34875339
16.
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
Cell Death Differ
; 29(9): 1816-1833, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35347235
17.
MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes.
Adv Sci (Weinh)
; 9(14): e2105539, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293697
18.
The small heat shock protein alphaA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis.
Biochim Biophys Acta
; 1802(7-8): 621-31, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20434541
19.
Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MERTK locus.
Stem Cell Res
; 53: 102310, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33812335
20.
Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance.
Aging (Albany NY)
; 13(13): 17568-17591, 2021 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34226295