Detalhe da pesquisa
1.
Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2.
Proc Natl Acad Sci U S A
; 119(52): e2203894119, 2022 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36534812
2.
Targeting leucine-rich repeat serine/threonine-protein kinase 2 sensitizes pancreatic ductal adenocarcinoma to anti-PD-L1 immunotherapy.
Mol Ther
; 31(10): 2929-2947, 2023 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37515321
3.
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies.
J Biomed Sci
; 29(1): 68, 2022 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36096815
4.
Quality Assessment of Artemisia rupestris L. Using Quantitative Analysis of Multi-Components by Single Marker and Fingerprint Analysis.
Molecules
; 27(9)2022 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35565985
5.
The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.
Nucleic Acids Res
; 47(19): 10426-10438, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31544921
6.
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Bioorg Chem
; 98: 103689, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32171993
7.
The homeobox gene MaH1 governs microcycle conidiation for increased conidial yield by mediating transcription of conidiation pattern shift-related genes in Metarhizium acridum.
Appl Microbiol Biotechnol
; 103(5): 2251-2262, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30631896
8.
Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance.
Autophagy
; : 1-21, 2024 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38174993
9.
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix.
Oncogene
; 42(25): 2061-2073, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37156839
10.
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.
Cell Death Differ
; 30(2): 560-575, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36539510
11.
Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 66(4): 2566-2588, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749735
12.
Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer.
Front Oncol
; 12: 862154, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35494080
13.
Global profiling of regulatory elements in the histone benzoylation pathway.
Nat Commun
; 13(1): 1369, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35296687
14.
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors.
J Immunother Cancer
; 10(3)2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35260434
15.
Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.
ACS Omega
; 6(9): 6100-6111, 2021 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33718701
16.
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
Cell Death Dis
; 12(4): 405, 2021 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33854041
17.
CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer.
Clin Transl Med
; 11(10): e587, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709767
18.
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Eur J Med Chem
; 224: 113673, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34303872
19.
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones.
Acta Pharm Sin B
; 10(7): 1309-1320, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32874830
20.
EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.
Signal Transduct Target Ther
; 4: 25, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31637005