Electrophoretic Microplate Protein Identification Based on Gold Staining of Molybdenum Disulfide Hydrogels.

Numerous high-performance nanotechnologies have been developed, but their practical applications are largely restricted by the nanomaterials' low stabilities and high operation complexity in aqueous substrates. Herein, we develop a simple and high-reliability hydrogel-based nanotechnology based on the in situ formation of Au nanoparticles in molybdenum disulfide (MoS2)-doped agarose (MoS2/AG) hydrogels for electrophoresis-integrated microplate protein recognition. After the incubation of MoS2/AG hydrogels in HAuCl4 solutions, MoS2 nanosheets spontaneously reduce Au ions, and the hydrogels are remarkably stained with the color of as-synthetic plasmonic Au hybrid nanomaterials (Au staining). Proteins can precisely mediate the morphologies and optical properties of Au/MoS2 heterostructures in the hydrogels. Consequently, Au staining-based protein recognition is exhibited, and hydrogels ensure the comparable stabilities and sensitivities of protein analysis. In comparison to the fluorescence imaging and dye staining, enhanced sensitivity and recognition performances of proteins are implemented by Au staining. In Au staining, exfoliated MoS2 semiconductors directly guide the oriented growth of plasmonic Au nanostructures in the presence of formaldehyde, showing environment-friendly features. The Au-stained hydrogels merge the synthesis and recognition applications of plasmonic Au nanomaterials. Significantly, the one-step incubation of the electrophoretic hydrogels leads to high simplicity of operation, largely challenging those multiple-step Ag staining routes which were performed with high complexity and formaldehyde toxicity. Due to its toxic-free, simple, and sensitive merits, the Au staining integrated with electrophoresis-based separation and microplate-based high-throughput measurements exhibits highly promising and improved practicality of those developing nanotechnologies and largely facilitates in-depth understanding of biological information.

The role of sialidase Neu1 in respiratory diseases.

Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.

Hydrolyzed Hydrated Titanium Oxide on Laser-Induced Graphene as CDI Electrodes for U(VI) Adsorption.

Recently, laser-induced graphene (LIG), which has been successfully applied in CDI technology (directly without a complex preparation process), has gained considerable attention. However, the raw LIG electrode with a limited number of active sites exhibits low adsorption efficiency. Therefore, the search for a suitable and effective method to modify LIG to improve its electroadsorption performance is significant. Herein, a very simple titration hydrolysis method is adopted to modify LIG, resulting in a layer of hydrated titanium oxide (HTO) being synthesized on the surface of LIG. The LIG/HTO composites possess a good adsorption property since covering the surface of LIG with a layer of HTO can greatly improve the adsorption capacity of LIG. Moreover, with the addition of HTO, not only the proton transfer ability of LIG has been enhanced but also considerable specific capacitance has been enlarged. As a result, LIG/HTO composite as CDI electrode displays a maximum theoretical adsorption capacity of 1780.89 mg/g at 1.2 V, and the capacitance of LIG/HTO composite material is 4.74 times higher than LIG. During the electroadsorption process, Ti4+ is reduced to Ti3+ under external voltage, and O2- is produced through oxidation. Meanwhile, part of the U (VI) is hydrolyzed into UO3·2H2O under the action of -OH, and some combine with O2- to produce UO4·4H2O.

Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia.

Acute myeloid leukemia (AML) is the most common type of blood cancer and has been strongly correlated with the overexpression of Fms-like tyrosine kinase 3 (FLT3), a member of the class III receptor tyrosine kinase family. With the emergence of FLT3 internal tandem duplication alteration (ITD) and tyrosine kinase domain (TKD) mutations, the development of FLT3 small molecule inhibitors has become an effective medicinal chemistry strategy for AML. Herein, we have designed and synthesized two series of 1H-pyrrolo[2,3-b]pyridine derivatives CM1-CM24, as FLT3 inhibitors based on F14, which we previously reported, that can target the hydrophobic FLT3 back pocket. Among these derivates, CM5 showed significant inhibition of FLT3 and FLT3-ITD, with inhibitory percentages of 57.72 % and 53.77 % respectively at the concentration of 1 µΜ. Furthermore, CM5 demonstrated potent inhibition against FLT3-dependent human AML cell lines MOLM-13 and MV4-11 (both harboring FLT3-ITD mutant), with IC50 values of 0.75 µM and 0.64 µM respectively. In our cellular mechanistic studies, CM5 also effectively induces apoptosis by arresting cell cycle progression in the G0/G1 phase. In addition, the amide and urea linker function were discussed in detail based on computational simulations studies. CM5 will serve as a novel lead compound for further structural modification and development of FLT3 inhibitors specifically targeting AML with FLT3-ITD mutations.

Dipole-multipole plasmonic coupling between gold nanorods and titanium nitride nanoparticles for enhanced photothermal conversion.

The plasmonic photothermal conversion efficiency can be enhanced by coupling among plasmonic atoms or plasmonic molecules due to the amplified local electric field and extinction cross-section. Recently, it has been theoretically proved that hybridization between dipolar modes and higher order modes can provide higher enhancement than that among dipolar modes in terms of both near- and far-field, which may lead to a higher photothermal conversion rate. In this work, we systematically investigated the photothermal conversion enhancement of plasmonic coupling between a dipolar mode of a titanium nitride nanoparticle (TiN NP) and a higher order mode of a gold nanorod (Au NR), which was compared to that of coupling among TiN NPs' dipolar modes. We evaluated the photothermal conversion efficiency of dipole-dipole coupling and dipole-multipole coupling in the nanocluster under the illumination of a monochromatic laser of 808 nm wavelength and simulated solar light, respectively. Both experimental tests and numerical simulations suggested that the plasmonic dipole-multipole coupling exhibited higher enhancement in photothermal conversion than dipole-dipole plasmonic coupling.

Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs.

The molecular mechanisms controlling the transition from meiotic arrest to meiotic resumption in mammalian oocytes have not been fully elucidated. Single-cell omics technology provides a new opportunity to decipher the early molecular events of oocyte growth in mammals. Here we focused on analyzing oocytes that were collected from antral follicles in different diameters of porcine pubertal ovaries, and used single-cell M&T-seq technology to analyze the nuclear DNA methylome and cytoplasmic transcriptome in parallel for 62 oocytes. 10× Genomics single-cell transcriptomic analyses were also performed to explore the bi-directional cell-cell communications within antral follicles. A new pipeline, methyConcerto, was developed to specifically and comprehensively characterize the methylation profile and allele-specific methylation events for a single-cell methylome. We characterized the gene expressions and DNA methylations of individual oocyte in porcine antral follicle, and both active and inactive gene's bodies displayed high methylation levels, thereby enabled defining two distinct types of oocytes. Although the methylation levels of Type II were higher than that of Type I, Type II contained nearly two times more of cytoplasmic transcripts than Type I. Moreover, the imprinting methylation patterns of Type II were more dramatically divergent than Type I, and the gene expressions and DNA methylations of Type II were more similar with that of MII oocytes. The crosstalk between granulosa cells and Type II oocytes was active, and these observations revealed that Type II was more poised for maturation. We further confirmed Insulin Receptor Substrate-1 in insulin signaling pathway is a key regulator on maturation by in vitro maturation experiments. Our study provides new insights into the regulatory mechanisms between meiotic arrest and meiotic resumption in mammalian oocytes. We also provide a new analytical package for future single-cell methylomics study.

Traditional Chinese medicine for gastric cancer: An evidence mapping.

As a complementary and alternative therapy, traditional Chinese medicine (TCM) has been playing a significant role in gastric cancer treatment. Data from individual systematic reviews have not been comprehensively summarized, and the relationship between certain interventions and outcomes are ill-defined. This study aimed to analyze the advantages of TCM interventions for gastric cancer by the method of evidence mapping. We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journals Database, and Wanfang Database for systematic reviews of TCM treating gastric cancer up to December 31, 2023. We used Excel, Endnote 20, and Python software for the analysis of incorporated studies. We assessed the quality of included SRs by AMSTAR-2 and performed evidence mapping including 89 SRs, 1648 RCTs and 122,902 patients, identifying 47 types of interventions and 39 types of outcomes. From a visual overview, we displayed that most SRs reported beneficial effects in improving short- and long-term survival, myelosuppression, and immune function, even though the quality of evidence was generally low. The benefits of Brucea javanica Oil Emulsion Injection, ShenQiFuZheng Injection, XiaoAiPing, Astragalus-Containing TCM and Guben Xiaoji Therapy were found the most solid in corresponding aspects. Our findings suggest that although more rigorous clinical trials and SRs are needed to identify the precise effectiveness, integrating such evidence into clinical care of gastric cancer is expected to be beneficial.

Oxygen vacancy-rich Fe2(MoO4)3 combined with MWCNTs for electrochemical sensors of fentanyl and its analogs.

Hundreds of thousands of people dying from the abuse of fentanyl and its analogs. Hence, the development of an efficient and highly accurate detection method is extremely relevant and challenging. Therefore, we proposed the introduction of oxygen defects into Fe2(MoO4)3 nanoparticles for improving the catalyst performance and combining it with multi-walled carbon nanotubes (MWCNTs) for electrochemical detection of fentanyl and its analogs. Oxygen vacancy-rich Fe2(MoO4)3 (called r-Fe2(MoO4)3) nanoparticles were successfully synthesized and characterized in detail by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectrometry (EDS), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Raman spectra, BET, X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) and investigated by comparison with oxygen vacancy-poor Fe2(MoO4)3 (called p-Fe2(MoO4)3). The obtained oxygen vacancy-rich Fe2(MoO4)3 was ultrasonically composited with MWCNTs for modification of glassy carbon electrodes (GCEs) used for the electrochemical detection of fentanyl and its analogs. The modified MWCNT-GCE showed ultrasensitivity to fentanyl, sufentanil, alfentanil, and acetylfentanyl with limits of detection (LOD) of 0.006 µmol·L-1, 0.008 µmol·L-1, 0.018 µmol·L-1, and 0.024 µmol·L-1, respectively, and could distinguish among the four drugs based on their peak voltages. Besides, the obtained r-Fe2(MoO4)3/MWCNT composite also exhibited high repeatability, selectivity, and stability. It showed satisfactory detection performance on real samples, with recoveries of 70.53 ~ 94.85% and 50.98 ~ 82.54% in serum and urine for the four drugs in a concentration range 0.2 ~ 1 µM, respectively. The experimental results confirm that the introduction of oxygen vacancies effectively improves the sensitivity of fentanyl electrochemical detection, and this work provides some inspiration for the development of catalytic materials for electrochemical sensors with higher sensitivity.

Label-Free Three-Dimensional Morphological Characterization of Cell Death Using Holographic Tomography.

This study presents a novel label-free approach for characterizing cell death states, eliminating the need for complex molecular labeling that may yield artificial or ambiguous results due to technical limitations in microscope resolution. The proposed holographic tomography technique offers a label-free avenue for capturing precise three-dimensional (3D) refractive index morphologies of cells and directly analyzing cellular parameters like area, height, volume, and nucleus/cytoplasm ratio within the 3D cellular model. We showcase holographic tomography results illustrating various cell death types and elucidate distinctive refractive index correlations with specific cell morphologies complemented by biochemical assays to verify cell death states. These findings hold promise for advancing in situ single cell state identification and diagnosis applications.

Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.

In female mammals, the proliferation and apoptosis of granulosa cells (GCs) have been shown to determine the fate of follicles. DNA methyltransferases (DNMTs) and SLCO3A1 have been reported to be involved in the survival of GCs and follicular growth. However, the molecular mechanisms enabling DNMTs to regulate the expression of SLCO3A1 to participate in follicular growth are unclear. In this study, we found that the knockdown of DNMT1 enhanced the mRNA and protein levels of SLCO3A1 by regulating the chromatin accessibility probably. Moreover, SLCO3A1 upregulated the mRNA and protein levels of MCL1, PCNA, and STAR to promote the proliferation of GCs and facilitated cell cycle progression by increasing the mRNA and protein levels of CCNE1, CDK2, and CCND1, but it decreased apoptosis by downregulating the mRNA and protein levels of CASP3 and CASP8. Moreover, SLCO3A1 promoted the growth of porcine follicles and development of mice follicles. In conclusion, the knockdown of DNMT1 upregulated the mRNA and protein levels of SLCO3A1, thereby promoting the proliferation of GCs to facilitate the growth and development of ovarian follicles, and these results provide new insights into investigations of female reproductive diseases.

Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore.

Owing to the predominance of dopamine (DA) in controlling mental health, planning an innovative method for DA detection with simplicity and high efficacy is conducive to the assessment of neurological disorders. Herein, an efficient fluorogenic tactic has been elaborated for ultrasensitive detection of DA with remarkably enhanced turn-on response. Utilizing a twisted intramolecular charge-transfer (TICT)-suppressing strategy, a highly emissive azocine derivative 11-hydroxy-2,3,6,7,11,12,13,14-octahydro-1H,5H,10H-11,14a-methanoazocino[5',4':4,5]furo[2,3-f]pyrido[3,2,1-ij]quinolin-10-one (J-Aza) is generated via a one-step reaction between DA and 8-hydroxyjulolidine. It is marvelous that J-Aza not only possesses ideal fluorescence quantum yield (ΦF) as high as 0.956 but also exhibits bathochromic shifted fluorescence (green emissive) and stronger anti-photobleaching capacity superior to traditional azocine-derived 1,2,3,4-tetrahydro-5H-4,11a-methanobenzofuro[2,3-d]azocin-5-one (Aza) with moderate ΦF, blue fluorescence, and poor photostability. By confining the TICT process, the detection limit to DA can be reduced to 80 pM, which is competitive in contrast to previously reported fluorescence methods. Encouraged by the instant response (within 90 s), wide linear range (0.1-500 nM), great selectivity, and excellent sensitivity, this fluorogenic method has been used for the real-time measurement of DA contents in practical urine samples with satisfactory results. Furthermore, the cerebral DA level in the reserpine-induced depression rat model has also been evaluated by our designed method, demonstrating its potent analytical applicability in the biosensing field.

Mercury-Mediated Epitaxial Accumulation of Au Atoms for Stained Hydrogel-Improved On-Site Mercury Monitoring.

Trivalent Au ions are easily reduced to be zerovalent atoms by coexisting reductant reagents, resulting in the subsequent accumulation of Au atoms and formation of plasmonic nanostructures. In the absence of stabilizers or presence of weak stabilizers, aggregative growth of Au nanoparticles (NPs) always occurs, and unregular multidimensional Au materials are consequently constructed. Herein, the addition of nanomole-level mercury ions can efficiently prevent the epitaxial accumulation of Au atoms, and separated Au NPs with mediated morphologies and superior plasmonic characteristics are obtained. Experimental results and theoretical simulation demonstrate the Hg-concentration-reliant formation of plasmonic nanostructures with their mediated sizes and shapes in the presence of weak reductants. Moreover, the sensitive plasmonic responses of reaction systems exhibit selectivity comparable to that of Hg species. As a concept of proof, polymeric carbon dots (CDs) were used as the initial reductant, and the reactions between trivalent Au and CDs were studies. Significantly, Hg atoms prevent the epitaxial accumulation of Au atoms, and plasmonic NPs with decreased sizes were in situ synthesized, corresponding to varied surface plasmonic resonance absorption performance of the CD-induced hybrids. Moreover, with the integration of sensing substrates of CD-doped hydrogels, superior response stabilities, analysis selectivity, and sensitivity of Hg2+ ions were achieved on the basis of the mercury-mediated in situ chemical reactions between trivalent Au ions and reductant CDs. Consequently, a high-performance sensing strategy with the use of Au NP-staining hydrogels (nanostaining hydrogels) was exhibited. In addition to Hg sensing, the nanostaining hydrogels facilitated by doping of emerging materials and advanced chem/biostrategies can be developed as high-performance on-site monitoring routes to various pollutant species.

In Situ Formed Gradient Composite Solid Electrolyte Interphase Layer for Stable Lithium Metal Anodes.

Lithium (Li) metal anode (LMA) is highly considered as a desirable anode material for next-generation rechargeable batteries because of its high specific capacity and the lowest reduction potential. However, uncontrollable growth of Li dendrites, large volume change, and unstable interfaces between LMA and electrolyte hinder its practical application. Herein, a novel in situ formed artificial gradient composite solid electrolyte interphase (GCSEI) layer for highly stable LMAs is proposed. The inner rigid inorganics (Li2 S and LiF) with high Li+ ion affinity and high electron tunneling barrier are beneficial to achieve homogeneous Li plating, while the flexible polymers (poly(ethylene oxide) and poly(vinylidene fluoride)) on the surface of GCSEI layer can accommodate the volume change. Furthermore, the GCSEI layer demonstrates fast Li+ ion transport capability and increased Li+ ion diffusion kinetics. Accordingly, the modified LMA enables excellent cycling stability (over 1000 h at 3 mA cm-2 ) in the symmetric cell using carbonate electrolyte, and the corresponding Li-GCSEI||LiNi0.8 Co0.1 Mn0.1 O2 full cell demonstrates 83.4% capacity retention after 500 cycles. This work offers a new strategy for the design of dendrite-free LMAs for practical applications.

A Novel Electrocatalyst Pd(II)@Ni3 (HITP)2 for Ultrasensitive Detection of Chloramphenicol: Experimental and Computational Investigation.

Ultrasensitive electrochemical detection on hazardous substances like antibiotics and pesticides is essential but still challenging in rapid test technology. Herein, the first electrode using highly conductive metal-organic frameworks (HCMOFs) for electrochemical detection of chloramphenicol is proposed. The design of electrocatalyst Pd(II)@Ni3 (HITP)2 with ultra-sensitivity in detection of chloramphenicol is demonstrated by loading Pd onto HCMOFs. An ultra-low limit of detection (LOD) of 0.2 nM (64.6 pg/mL) was observed for these materials, which is 1-2 orders of magnitude lower than the other reported materials for chromatographic detection. Moreover, the proposed HCMOFs showed long-time stability over 24 h. The superior detection sensitivity can be attributed to the high conductivity of Ni3 (HITP)2 , and the large Pd loading. The experimental characterizations and computational investigation determined the Pd loading mechanism in Pd(II)@Ni3 (HITP)2 , revealing PdCl2 adsorption on the abundant adsorption sites of Ni3 (HITP)2 . The proposed electrochemical sensor design using HCMOFs was demonstrated to be both effective and efficient, showing that the adoption of HCMOFs decorated with other effective electrocatalysts, which combine high conductivity and high catalytic activity, is of great advantage for ultrasensitive detection.

Chitosan Sponge/Cu-WO3-x Composite for Photodynamic Therapy of Wound Infection.

One of the potential treatments for bacterial wound infections is photodynamic therapy. WO3-x semiconductor materials can generate reactive oxygen species when exposed to light, which can inactivate bacteria. In this work, we improved their photocatalytic performance by doping WO3-x with Cu. The wound dressing was prepared by loading Cu-WO3-x into a highly biocompatible chitosan sponge. The composite sponge dressing showed significant inactivation of Escherichia coli and Staphylococcus aureus, and in vitro toxicity assays on L929 cells demonstrated the biosafety of the dressing. Through in vivo wound healing trials, composite sponge dressings have been shown to accelerate wound healing, and this composite chitosan sponge can be possibly used for photodynamic therapy of bacterial wound infections.

Tracking the Growth of Chiral Plasmonic Nanocrystals at Molybdenum Disulfide Heterostructural Interfaces.

The way of accurately regulating the growth of chiral plasmonics is of great importance for exploring the chirality information and improving its potential values. Herein, cysteine enantiomers modulate the anisotropic and epitaxial growth of gold nanoplasmonics on seeds of exfoliated MoS2 nanosheets. The heterostructural Au and MoS2 hybrids induced by enantiomeric cysteine are presented with chiroptical characteristics, dendritic morphologies, and plasmonic performances. Moreover, the synthesis, condition optimization, formation mechanism, and plasmonic properties of Au and MoS2 dendritic nanostructures are studied. The chirality characteristics are identified using the circular dichroism spectra and scanning electron microscopy. Time-resolved transmission electron microscopy and UV-vis spectra of the intermediate products captured are analyzed to confirm the formation mechanism of dendritic plasmonic nanostructures at heterostructural surfaces. The specific dendritic morphologies originate from the synergistic impacts of heterostructural MoS2 interfaces and enantiomeric cysteine-induced anisotropic manipulation. Significantly, the developed synthesis strategy of chiral nanostructures at heterostructural interfaces is highly promising in promoting the understanding of the plasmonic function and crucial chirality bioinformation.

A series of ultrasensitive electrocatalysts Fe-MOF/MWCNTs for fentanyl determination.

Electrochemical determination of synthetic opioids such as fentanyl is meaningful but still challenging no matter from a social or academic perspective. Herein, we report a series of novel electrocatalysts based on Fe-containing metal-organic frameworks and multi-walled carbon nanotubes (Fe-MOF/MWCNTs). The obtained Fe-MOF/MWCNT electrode materials all show ultrasensitivity on fentanyl determination. In particular, MOF-235/MWCNTs even exhibit an ultra-low limit of detection (LOD) of 0.03 µM with a wide linear range from 0.1 to 50 µM. Besides, this series of Fe-MOF/MWCNTs also displays excellent repeatability, selectivity, and stability. Moreover, they show good performance in real sample detection and achieve good recovery of 95.47%-102.41% and 96.62%-103.15% in blood and urine samples, respectively. This high performance in fentanyl determination is mainly contributed by the Fenton-like process and the adsorption function of the Fe-MOF. Therefore, these novel Fe-MOF/MWCNTs are promising electrocatalysts for point-of-care device fabrication and also have potential applications in fentanyl rapid test technology.

Engineered Superhydrophilic/Superaerophobic Catalyst: Two-Dimensional Co(OH)2-CeO2 Nanosheets Supported on Three-Dimensional Co Dendrites for Overall Water Splitting.

Efficient electrocatalysts require not only a tunable electronic structure but also great active site accessibility and favorable mass transfer. Here, a two-dimensional/three-dimensional (2D/3D) hierarchical electrocatalyst consisting of Co(OH)2-CeO2 nanosheet-decorated Co dendrites is proposed, named as Co(OH)2-CeO2/Co. Based on the strong electronic interaction of the Co(OH)2-CeO2 heterojunction, the electronic structure of the Co site is optimized, which facilitates the adsorption of intermediates and the dissociation of H2O. Moreover, the open 2D/3D structure formed by introducing the Co substrate further reduces the accumulation of heterogeneous nanosheets and promotes the radial diffusion of the electrolyte, significantly improving the utilization of active sites and shortening the electron transfer pathway. In addition, the superhydrophilic/superaerophobic interface achieved by constructing the hierarchical micro-nanostructure is beneficial to electrolyte infiltration and bubble desorption, thus ensuring favorable mass transfer. Therefore, Co(OH)2-CeO2/Co exhibits an excellent overall water-splitting activity in alkaline solution.

High-performance electrode of ZIF-67 metal-organic framework (MOF) loaded laser-induced graphene (LIG) composite for all-solid-state supercapacitor.

This work demonstrates a facile and efficient methodology to synthesize a composite material of zeolitic imidazolate frameworks (ZIFs) and laser-induced graphene (LIG). This ZIF-67 loaded LIG composite (ZIF-67/LIG) has been adequately characterized for its morphology and structure, and its electrochemical performance has been specifically examined. As supercapacitors (SCs) electrode material, the ZIF-67/LIG composite exhibits superb electrochemical performance, owing to the inherent high porosity, abundant active sites, large specific surface area of ZIF-67, and the excellent conductive three-dimensional hierarchical porous network structure provided by LIG. In three-electrode system, ZIF-67/LIG composite electrode displays outstanding areal specific capacitance (CA) of 135.6 mF cm-2at a current density of 1 mA cm-2with 1 M Na2SO4aqueous electrolyte, which is far greater than that of pristine LIG (7.7 mF cm-2). Furthermore, the ZIF-67/LIG composite has been fabricated into an all-solid-state planar micro-supercapacitor (MSC). This ZIF-67/LIG MSC exhibits an impressiveCAof 38.1 mF cm-2at a current density of 0.20 mA cm-2, a good cycling stability of 80.3% capacitance retention after 3000 cycles, and a high energy density of 5.29µWh cm-2at a power density of 0.1 mW cm-2. All electrochemical results clearly manifest that as-prepared ZIF-67/LIG composite can be a candidate in energy storage field with exciting possibilities.

A wide-range ratiometric sensor mediating fluorescence and scattering based on carbon dots/metal-organic framework composites for the detection of bisulfite/sulfite in sugar.

Bisulfite (HSO3-) and sulfite (SO32-) are commonly employed in food preservatives and are also significant environmental pollutants. Thus, developing an effective method for detecting HSO3-/SO32- is crucial for food safety and environment monitoring. In this work, based on carbon dots (CDs) and zeolitic imidazolate framework-90 (ZIF-90), a composite probe (named CDs@ZIF-90) is constructed. The fluorescence signal and the second-order scattering signal of CDs@ZIF-90 are employed to ratiometricly detect HSO3-/SO32-. This proposed strategy exhibits a broad linear range for HSO3-/SO32- determination (10 µM to 8.5 mM) with a limit of detection of 2.74 µM. This strategy is successfully applied for evaluating HSO3-/SO32- in sugar with satisfactory recoveries. Therefore, this work has uniquely combined the fluorescence and second-order scattering signals to establish a novel sensing system with a wide linear range, which is applicable for ratiometric sensing of HSO3-/SO32- in actual samples.