Detalhe da pesquisa
1.
Clinical pharmacology considerations for first-in-human clinical trials for enzyme replacement therapy.
J Inherit Metab Dis
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740427
2.
FDA approval summary for lonafarnib (Zokinvy) for the treatment of Hutchinson-Gilford progeria syndrome and processing-deficient progeroid laminopathies.
Genet Med
; 25(2): 100335, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36507973
3.
FDA Approval Summary: Selinexor for Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
Oncologist
; 26(10): 879-886, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34132444
4.
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.
Circ Res
; 122(3): 457-472, 2018 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29279301
5.
Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
Angew Chem Int Ed Engl
; 58(48): 17158-17162, 2019 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591797
6.
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.
Proc Natl Acad Sci U S A
; 112(52): E7276-85, 2015 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26655341
7.
Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.
J Neurosci
; 35(31): 11056-67, 2015 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26245967
8.
FDA Approval Summary: Ivosidenib in Combination with Azacitidine for Treatment of Patients with Newly Diagnosed Acute Myeloid Leukemia with an IDH1 Mutation.
Clin Cancer Res
; 30(7): 1226-1231, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010220
9.
Model-Informed Approach Supporting Approval of Nexviazyme (Avalglucosidase Alfa-ngpt) in Pediatric Patients with Late-Onset Pompe Disease.
AAPS J
; 25(1): 16, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36653728
10.
Timing of surgical operation for patients with intra-abdominal infection: A systematic review and meta-analysis.
World J Gastrointest Surg
; 15(10): 2320-2330, 2023 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37969709
11.
Model-Informed Approach Supporting Approval of Adalimumab (HUMIRA) in Pediatric Patients with Ulcerative Colitis from a Regulatory Perspective.
AAPS J
; 24(4): 79, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35790574
12.
Model-Informed Approach Supporting Drug Development and Regulatory Evaluation for Rare Diseases.
J Clin Pharmacol
; 62 Suppl 2: S27-S37, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36461744
13.
FDA Approval Summary: Belumosudil for Adult and Pediatric Patients 12 Years and Older with Chronic GvHD after Two or More Prior Lines of Systemic Therapy.
Clin Cancer Res
; 28(12): 2488-2492, 2022 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35135839
14.
Targeting therapy with mitosomal daunorubicin plus amlodipine has the potential to circumvent intrinsic resistant breast cancer.
Mol Pharm
; 8(1): 162-75, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062083
15.
Model-Informed Drug Development in Pediatric Dose Selection.
J Clin Pharmacol
; 61 Suppl 1: S60-S69, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34185906
16.
Effects of stealth liposomal daunorubicin plus tamoxifen on the breast cancer and cancer stem cells.
J Pharm Pharm Sci
; 13(2): 136-51, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20816001
17.
Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors.
ACS Med Chem Lett
; 11(6): 1111-1117, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550989
18.
FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults.
Clin Cancer Res
; 26(2): 328-331, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31444252
19.
Role of Model-Informed Drug Development in Pediatric Drug Development, Regulatory Evaluation, and Labeling.
J Clin Pharmacol
; 59 Suppl 1: S104-S111, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31502691
20.
Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition.
J Med Chem
; 61(24): 11158-11168, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30481027