Detalhe da pesquisa
1.
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell
; 186(22): 4956-4973.e21, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37852260
2.
Intrinsic bias at non-canonical, ß-arrestin-coupled seven transmembrane receptors.
Mol Cell
; 81(22): 4605-4621.e11, 2021 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582793
3.
Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing.
Proc Natl Acad Sci U S A
; 121(5): e2314627121, 2024 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38252818
4.
Emerging Insights into the Structure and Function of Complement C5a Receptors.
Trends Biochem Sci
; 45(8): 693-705, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32402749
5.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Mol Psychiatry
; 28(7): 2878-2893, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-36316366
6.
Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages.
J Immunol
; 208(1): 133-142, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34853076
7.
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
J Immunol
; 205(4): 1102-1112, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32611725
8.
The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity.
J Immunol
; 202(12): 3339-3348, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31160390
9.
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.
J Biol Chem
; 294(24): 9416-9429, 2019 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31036565
10.
C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma.
FASEB J
; 33(10): 11060-11071, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31298935
11.
Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation.
STAR Protoc
; 4(4): 102758, 2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38032798
12.
TLQP-21 is a low potency partial C3aR activator on human primary macrophages.
Front Immunol
; 14: 1086673, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36776827
13.
Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists.
Int Immunopharmacol
; 100: 108074, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34454293
14.
Development of Synthetic Human and Mouse C5a: Application to Binding and Functional Assays In Vitro and In Vivo.
ACS Pharmacol Transl Sci
; 4(6): 1808-1817, 2021 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34927012
15.
Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity.
J Med Chem
; 64(22): 16598-16608, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762432
16.
The "C3aR Antagonist" SB290157 is a Partial C5aR2 Agonist.
Front Pharmacol
; 11: 591398, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33551801
17.
Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function.
Biochem Pharmacol
; 180: 114156, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32682759
18.
Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2.
JCI Insight
; 4(9)2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31045582
19.
New concepts on the therapeutic control of complement anaphylatoxin receptors.
Mol Immunol
; 89: 36-43, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28576324