Coverage extended MMF-based indoor OWC using overfilled launch and diversity reception.

Speckle patterns generated as coherent optical beams are reflected by scattering elements. Multimode fibers (MMFs) can modify the transverse intensity distribution of speckle patterns with macro perturbations, i.e., pressures, providing a simple and low-cost way to achieve equivalent beam-steering for indoor optical wireless communications (OWCs) with divergent optical beams. However, the received optical power (ROP) variance severely limits the mobility of user terminals. In this paper, the issue is alleviated by using the overfilled launch of MMFs and the diversity gain of multi-receivers. By adjusting the axial spatial coupling distance between the MMF and the single mode fiber (SMF) emitting coherent laser, the number of excited modes of MMF can be significantly increased at 1550 nm with negligible coupling and bending losses. In addition, the signal-to-noise ratio (SNR) enhancement obtained by applying two receivers is theoretically analyzed for the case when either thermal noise or shot noise is dominant. The experimental results demonstrate that the proposed scheme can efficiently compensate for the ROP inhomogeneity, and at the same time it can extend the achievable full steering angle up to 12° at a 1.5-m free-space distance for bit error rate (BER) values of less than 3.8 × 10-3.

Anti-noise UWFBG-array enhanced DAS system using double-pulse-based time-domain adaptive delay interference: publisher's note.

This publisher's note contains a correction to Opt. Lett.48, 1814 (2023)10.1364/OL.486149.

Urine LMs quantitative analysis strategy development and LMs CWP biomarkers discovery.

Coal workers' pneumoconiosis (CWP) is one of the most common inhalation occupational diseases. It is no effective treatment methods. Early diagnosis of CWP could reduce mortality. Lipid mediators (LMs) as key mediators in the generation and resolution of inflammation, are natural biomarkers for diagnosis inflammatory disease, such as CWP. The UHPLC-MRM technique was used to detect LMs in urine. The metabolic network of LMs in CWP and CT group samples was comprehensively analyzed. Screening for major difference compounds between the two groups. Aimed to contribute to the early diagnosis and treatment of CWP. Urinary levels of 13-OxoODE, 9-OxoODE, and 9,10-EpOME were significantly higher in the CWP group compared with the CT group (P < 0.05). In the model group, the area under the receiver operating characteristic (ROC) for 9-OxoODE,13-OxoODE,9,10-EpOME was 84.4%, 73.3%, and 80.9%, respectively. In the validation group, the area under the ROC was 87.0%, 88.8%, and 68.8% for 9-OxoODE,13-OxoODE,9,10-EpOME, respectively. According to the logistic regression model, the area under the ROC was 80.4% in the model group and 86.7% in the validation group. 13-OxoODE,9-OxoODE,9,10-EpOME could be used as biomarkers for early diagnosis. Significant abnormalities of LOX and CYP450 enzyme pathways were seen in CWP organisms. Changes in the CYP450 enzyme pathway may be associated with PAHs.

Resolvin and lipoxin metabolism network regulated by Hyssopus Cuspidatus Boriss extract in asthmatic mice.

Resolvin (Rv) and lipoxin (Lx) play important regulative roles in the development of several inflammation-related diseases. The dysregulation of their metabolic network is believed to be closely related to the occurrence and development of asthma. The Hyssopus Cuspidatus Boriss extract (SXCF) has long been used as a treatment for asthma, while the mechanism of anti-inflammatory and anti-asthma action targeting Rv and Lx has not been thoroughly investigated. In this study, we aimed to investigate the effects of SXCF on Rv, Lx in ovalbumin (OVA)-sensitized asthmatic mice. The changes of Rv, Lx before and after drug administration were analyzed based on high sensitivity chromatography-multiple response monitoring (UHPLC-MRM) analysis and multivariate statistics. The pathology exploration included behavioral changes of mice, IgE in serum, cytokines in BALF, and lung tissue sections stained with H&E. It was found that SXCF significantly modulated the metabolic disturbance of Rv, Lx due to asthma. Its modulation effect was significantly better than that of dexamethasone and rosmarinic acid which is the first-line clinical medicine and the main component of Hyssopus Cuspidatus Boriss, respectively. SXCF is demonstrated to be a potential anti-asthmatic drug with significant disease-modifying effects on OVA-induced asthma. The modulation of Rv and Lx is a possible underlying mechanism of the SXCF effects.

A novel SPE-LC-MRM strategy for serum demethylzeylasteral quantitation developed with an 18O-labeled internal standard.

Natural bioactive compounds (NBCs) are widely used in clinical treatment. For example, Tripterygium wilfordii Hook f. is commonly known in China as Lei-Gong-Teng which means thunder god vine. This herb is widely distributed in Eastern and Southern China, Korea, and Japan. The natural bioactive compounds of this herb can be extracted and made into tripterygium glycoside tablets. It is one of the most commonly used and effective traditional Chinese herbal medicines against rheumatoid arthritis (RA), nephrotic syndrome (NS), autoimmune hepatis (AIH), and so on. However, many NBCs are difficult to reliably quantify in the serum due to the effects of matrix and RSD. In addition, the targeted compound's internal standard (IS) is rarely sold due to the complex isotope internal standard synthesis pathway. In this study, a new quantitation method for 18O labeling combined with off-line SPE was formulated. We contrasted the recoveries and matrix effects of various separation methods in order to choose the best method. Furthermore, we optimized the conditions for SPE loading and washing. An isotopic internal standard was prepared by the 16O/18O exchanging reaction in order to eliminate the matrix effects. The method's accuracy and precision met the requirements for method validation. The recovery of this method was close to 60%. The relative standard deviation (RSD) of the high-concentration sample was 2%, and the limit of detection (LOD) was 1 ng/mL. This method could be used to analyze the clinical serum concentration of demethylzeylasteral. Sixty samples were collected from 10 patients with diabetes nephropathy. The quantitation results of demethylzeylasteral in patients' serum obtained using this method exhibited a correlation between therapeutic drug monitoring (TDM) and decreased urinary protein. This work may have broad implications for the study of drug metabolism in vivo and the clinical application of low-abundance and difficult-to-quantify NBCs.

Variational mode decomposition-based abnormal wheel-rail relationship detection in distributed acoustic sensing.

The distributed acoustic sensing system can obtain the vibration signal caused by the vibration of the train. By analyzing these wheel-rail vibration signals, an abnormal wheel-rail relationship identification scheme is proposed. The variational mode decomposition is employed for signal decomposition, thereby obtaining intrinsic mode functions with prominent abnormal fluctuations. The kurtosis value of each intrinsic mode function is calculated, which is compared with the threshold value for the identification of trains with abnormal wheel-rail relationship. And the extreme point of the abnormal intrinsic mode function is used to locate the bogie with an abnormal wheel-rail relationship. Experimental demonstration verifies that the proposed scheme can identify the train and locate the bogie with an abnormal wheel-rail relationship.

Anti-noise UWFBG-array enhanced DAS system using double-pulse-based time-domain adaptive delay interference.

An anti-noise interrogation technique for ultra-weak fiber Bragg grating (UWFBG)-based distributed acoustic sensing (DAS) systems is proposed and demonstrated using double-pulse-based time-domain adaptive delay interference. This technique breaks the limitation that the optical path difference (OPD) between the two arms of the interferometer should be completely matched with the entire OPD between the adjacent gratings in the traditional single-pulse system. The length of the delay fiber in the interferometer can be reduced, and the double-pulse interval can adapt flexibly to the UWFBG array with different grating spacing. The acoustic signal is restored accurately when the grating spacing is 15 m or 20 m by the time-domain adjustable delay interference. Moreover, the noise induced by the interferometer can be suppressed significantly as compared to using a single pulse, and above 8-dB signal-to-noise ratio (SNR) enhancement can be obtained without any extra optical devices when the noise frequency and the vibration acceleration are below 100 Hz and 0.1 m/s2, respectively.

Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization.

The regulation of muscle glucose utilization has significant potential for the treatment of type 2 diabetes mellitus (T2DM) and obesity. Heat shock factor 1 (HSF1) is involved in cellular metabolism and regulation of muscle metabolism. However, it is unclear how HSF1 regulates muscle glucose metabolism. In the present study, the development of obesity in mice was associated with HSF1 downregulation. Serum samples and muscle biopsies were obtained from obese and healthy humans. Fasting glucose and insulin levels and the homeostasis model assessment of insulin resistance value showed that obesity was associated with insulin resistance. The skeletal muscle level of HSF1 was decreased in obese and ob/ob mice. HSF1 was selectively over-expressed in the skeletal muscles of high fat diet (HFD)-fed mice. Muscle HSF1 over-expression successfully triggered glycolytic-to-oxidative myofiber switch and increased fatty acid metabolism and insulin sensitivity in the skeletal muscles of HFD-fed mice. Moreover, HSF1 improved energy expenditure and blocked muscle accumulation of triglycerides in HFD-fed mice. Consequently, muscle HSF1 mitigated the impaired muscle insulin signaling and insulin resistance in HFD-fed mice. In conclusion, T2DM and obesity in HFD-fed mice may be treated with selective HSF1-directed programming of exercise-like effects in skeletal muscle. These findings may aid the development of a new therapeutic approach for obesity and T2DM.

Simulation of Layer Thickness Measurement in Thin Multi-Layered Material by Variable-Focus Laser Ultrasonic Testing.

Thin multi-layered materials are widely used in key structures of many high technology industries. To ensure the quality and safety of structures, layer thickness measurement by non-destructive testing (NDT) techniques is essential. In this paper, a novel approach for the measurement of each layer's thickness in thin multi-layered material is proposed by using ring-shaped laser generated focused ultrasonic bulk waves. The proposed method uses a ring-shaped laser with a variable radius to generate shear waves with variable focus inside the structure. By analyzing the signal characteristics at the ring center when the laser radius varies from zero to maximum, the direct measurement of layer thickness can be realized, considering that only when the focal depth and the layer thickness satisfy the specific relationship, the reflected shear waves converge and form a peak at the ring center. This straightforward approach can increase the pulse-echo SNR and prevent the processing of aliasing signals, and therefore provides higher efficiency and accuracy for the layer thickness measurement. In order to investigate the feasibility of this method, finite element simulations were conducted to simulate the ring-shaped laser generated ultrasonic waves in multi-layered structure in detail. Following the principle of the proposed method, the layer thickness of a bi-layer and 3-layer structure were respectively measured using simulation data. The results confirm that the proposed method can accurately and efficiently measure the layer thickness of thin multi-layered material.

Numerical simulation of optical refractometric sensing of multiple disease markers based on lab-in-a-fiber.

A multi-parameter optical refractometric sensor based on lab-in-a-fiber is proposed and its sensing properties have been investigated. Based on the particular three suspended-core fiber, the sensor has three channels for liquid circulation and three suspended cores for detection. The multiple disease markers can be detected by coating the specific bio-recognition layer on the surface of three channels. The bio-recognition layer thickness, representing the concentration of the disease markers, can then be measured by the wavelength of fiber Bragg grating inscribed in each suspended core. Owing to the triple symmetry of the fiber, the sensitivity of each core is similar. The simulation results show that the grating wavelength linearly changes with the bio-recognition layer thickness variation. Through the sensitivity matrix, the sensitivity of the sensor is 0.362 nm/nm and the sensing accuracy is ± 1 nm.

Polarization fading suppression in distributed interferometric sensing by matched interference between polarization-switched pulses.

A polarization fading suppression technique is proposed for distributed interferometric sensing systems, based on matched interference between polarization switched pulses. For each individual sensor, two sets of interferometric outputs are obtained, one corresponding to the interference between two pulses with initially parallel polarization, the other corresponding to that between two pulses with initially orthogonal polarizations. As such, at least one output presents visibility no less than 2/2. By selecting the one with higher visibility for demodulation, the influence of polarization fading can be suppressed significantly, leading to distributed acoustic sensing with notably improved robustness and reliability.

FBG pressure sensor in pressure distribution monitoring of ship.

In order to realize the multi-point load measurement of ship hull during wave experiments, an FBG pressure sensor was developed to monitor ship bottom liquid level. The principle is to measure the responses of optical fiber sensing units caused by hydraulic pressure. By utilizing a designed steel diamond structure and reasonable selected material, the sensor realized the temperature self-compensation function of a single FBG. The theoretical models and experimental methods are analyzed in detail. Lots of sensing tests showed that, the sensor had a sensitivity of 58.94 pm/kPa and a precision of 1.7 Pa. The temperature sensitivity was only 2.7 pm/°C, which basically achieved the effect of temperature self-compensated. Finally, 15 sensors were installed at the bottom of the hull and a series of wave load experiments were carried out, which further showed that the pressure sensor had good measuring ability and wide application prospect.

Intrusion identification using GMM-HMM for perimeter monitoring based on ultra-weak FBG arrays.

Intrusion identification has been an intractable task for perimeter security. One of the primary challenges is to possess high identification rate over a long-distance range monitoring. This paper proposes an intrusion identification scheme based on ultra-weak fiber Bragg grating (UWFBG) arrays. The scheme is acquired by the combination of a Gaussian mixture model (GMM) and a hidden Markov model (HMM). The time dependencies are obtained by the analysis of relevant sensors in UWFBG arrays from the procedure of intrusions. The features extracted from vibration signals with time dependencies are used as the input of GMM-HMM. The GMM-HMM simultaneously analyzes features and time dependencies to identify intrusion. Experimental demonstration verifies that the proposed scheme can identify three intrusions (walking, knocking and climbing) and two non-intrusions (heavy truck passing and wind blowing) with the average identification rate of 98.2%. By the comparison tests with other six classifiers, the proposed GMM-HMM scheme shows a solid performance in the integrated evaluation for intrusion identification.

High-speed multi-parametric photoacoustic microscopy of cerebral hemodynamic and metabolic responses to acute hemodilution.

The ability of hemodilution to improve vascular circulatory impairment has been demonstrated. However, the effects of acute hemodilution on cerebral hemodynamics and oxygen metabolism have not been assessed at the microscopic level, due to technical limitations. To fill this void, we have developed a new, to the best of our knowledge, photoacoustic microscopy system, which enables high-speed imaging of blood hemoglobin concentration, oxygenation, flow, and oxygen metabolism in vivo. The system performance was examined in both phantoms and the awake mouse brain. This new technique enabled wide-field (4.5 × 3 mm2) multi-parametric imaging of the mouse cortex at 1 frame/min. Narrowing the field of view to 1.5 × 1.5 mm2 allowed dynamic imaging of the cerebral hemodynamic and metabolic responses to acute hypervolemic hemodilution at 6 frames/min. Quantitative analysis of the hemodilution-induced cerebrovascular responses over time showed rapid increases in the vessel diameter (within 50-210 s) and blood flow (50-210 s), as well as decreases in the hemoglobin concentration (10-480 s) and metabolic rate of oxygen (20-480 s) after the acute hemodilution, followed by a gradual recovery to the baseline levels in 1440 s. Providing comprehensive insights into dynamic changes of the cerebrovascular structure and function in vivo, this technique opens new opportunities for mechanistic studies of acute brain diseases or responses to various stimuli.

Clinical effect of different maintenance doses of caffeine citrate in the treatment of preterm infants requiring assisted ventilation: a pilot multicenter study. / ä¸åŒç»´æŒå‰‚é‡æž¸æ©¼é ¸å’–å•¡å› å¯¹è¾ åŠ©é€šæ°”æ—©äº§å„¿çš„ç–—æ•ˆè¯„ä¼°ï¼šä¸€é¡¹åˆæ­¥å¤šä¸­å¿ƒç ”ç©¶.

OBJECTIVES: To explore the optimal maintenance dose of caffeine citrate for preterm infants requiring assisted ventilation and caffeine citrate treatment. METHODS: A retrospective analysis was performed on the medical data of 566 preterm infants (gestational age ≤34 weeks) who were treated and required assisted ventilation and caffeine citrate treatment in the neonatal intensive care unit of 30 tertiary hospitals in Jiangsu Province of China between January 1 and December 31, 2019. The 405 preterm infants receiving high-dose (10 mg/kg per day) caffeine citrate after a loading dose of 20 mg/kg within 24 hours after birth were enrolled as the high-dose group. The 161 preterm infants receiving low-dose (5 mg/kg per day) caffeine citrate were enrolled as the low-dose group. RESULTS: Compared with the low-dose group, the high-dose group had significant reductions in the need for high-concentration oxygen during assisted ventilation (P=0.044), the duration of oxygen inhalation after weaning from noninvasive ventilation (P<0.01), total oxygen inhalation time during hospitalization (P<0.01), the proportion of preterm infants requiring noninvasive ventilation again (P<0.01), the rate of use of pulmonary surfactant and budesonide (P<0.05), and the incidence rates of apnea and bronchopulmonary dysplasia (P<0.01), but the high-dose group had a significantly increased incidence rate of feeding intolerance (P=0.032). There were no significant differences between the two groups in the body weight change, the incidence rates of retinopathy of prematurity, intraventricular hemorrhage or necrotizing enterocolitis, the mortality rate, and the duration of caffeine use (P>0.05). CONCLUSIONS: This pilot multicenter study shows that the high maintenance dose (10 mg/kg per day) is generally beneficial to preterm infants in China and does not increase the incidence rate of common adverse reactions. For the risk of feeding intolerance, further research is needed to eliminate the interference of confounding factors as far as possible.

Vital signs monitoring using the macrobending small-core fiber sensor.

Respiration and heartbeat monitoring during sleep is essential in the assessment of personal health. However, conventional monitoring systems are complex, expensive, and uncomfortable. In this Letter, a mat embedded with a macrobending optical fiber sensor is proposed for non-contact vital signs monitoring during sleep based on vibration sensing. Exploiting the whispering gallery mode, a small-core fiber is adopted and pre-bent to enhance sensitivity to subtle vibrations. The mat sensing system can simultaneously detect and track respiration and ballistocardiography. With high vibration sensitivity, high reliability, and good stability, the mat provides a non-contact and low-cost alternative for long-term monitoring of vital signs, especially for daily home use.

High dynamic range distributed acoustic sensing based on dual-wavelength fiber Bragg grating pairs.

A high dynamic range distributed acoustic sensing (DAS) system is demonstrated based on a dual-wavelength (2λ) interferometric acoustic sensor array, constructed using 2λ fiber Bragg grating pairs (FBGPs). Each FBGP is composed of two weak FBGs presenting -30-dB reflectivity and center wavelengths of 1535 nm and 1565 nm. With the phase demodulation results from the two wavelengths, 2λ linear regression phase unwrapping is implemented, which significantly enhances the dynamic range of the DAS system. By examining the four time-division-multiplexed sensors, an average background noise level of -105.2dBrad/Hz at 1 kHz and a cross talk level lower than -70dB at 1 kHz are achieved.

Wear measurement based on the length variation of a sacrificial FBG.

A high-precision wear measurement method with temperature stability achieved by measuring the length variation of a fiber Bragg grating (FBG) is proposed. The adoption of the optical frequency-domain reflectometry (OFDR) technology makes the spatial resolution of this measurement method reach 15.13 µm, and the offline and online measurement accuracies are 30 µm and 100 µm, respectively. The systematic error of the FBG length measuring system is within 30 µm. Because the length measurement is done with a short FBG instead of a much longer fiber, the measurement error induced by the time-varying temperature or strain is significantly reduced in the proposed method. The spatial resolution and accuracy of this method is suitable for wear measurements of various parts in the mechanical field, such as bearings, gears, and pistons.

Surface intrusion event identification for subway tunnels using ultra-weak FBG array based fiber sensing.

A scheme is proposed for the identification of surface intrusion events, from signals detected by an ultra-weak fiber Bragg grating array in a subway tunnel. The spectral subtraction and the root mean square of the power spectral density are combined to extract event signals. The local characteristics-scale decomposition and the multi-scale permutation entropy are employed subsequently for feature extraction, which can improve the event recognition rate from the perspective of multi-scale analysis. Experimental demonstration verifies that the proposed scheme can identify four common events. Among the events, the discrete pulse construction and the continuous pulse construction on the ground surface are intrusion events, the subway train traveling in the tunnel and the lorry passing on the ground surface are non-intrusion events. The average recognition rate of 96.57% is achieved, which can satisfy actual application requirements.

High-sensing-resolution distributed hot spot detection system implemented by a relaxed pulsewidth.

Reliable sensing and accurate location of a weak and small hot spot are critical for applications in industrial infrastructure monitoring. We propose and experimentally demonstrate a practical and reliable distributed hot spot detection method using ultra-weak fiber Bragg gratings (UWFBGs) array and optical time-domain reflectometry (OTDR) based interrogator. To reliably detect the hot spots, the grating spacing of the sensor array is decreased to a similar size of the hot spot. All UWFBGs within a fiber section (FS) are considered as one sensing element, and the wavelength-division multiplexing technique is introduced to reduce crosstalk between adjacent FSs. To retrieve the sensing information, the proposed FS spectrum interrogation method based on OTDR technology is numerically analyzed and experimentally demonstrated. The interrogator exploits the reflection spectrum of each FS instead of each grating, enabling the low-speed hardware implementation of the whole demodulation method. Experimental results show that the expected hot spot can be successfully detected with a sensing resolution of 10 cm and a location resolution of 1 m over a range of 2 km by exploiting 10-ns pulsewidth. Besides, the temperature measurement can be demonstrated with a temperature sensing precision of ± 1°C and a measurement time of 1.5 s, which are meaningful for the early warning of centimeters-sized fire source in some oil and gas pipelines monitoring applications.