Use machine learning to help identify possible sarcopenia cases in maintenance hemodialysis patients.

BACKGROUND: Maintenance hemodialysis (MHD) patients often suffer from sarcopenia, which is strongly associated with their long-term mortality. The diagnosis and treatment of sarcopenia, especially possible sarcopenia for MHD patients are of great importance. This study aims to use machine learning and medical data to develop two simple sarcopenia identification assistant tools for MHD patients and focuses on sex specificity. METHODS: Data were retrospectively collected from patients undergoing MHD and included patients' basic information, body measurement results and laboratory findings. The 2019 consensus update by Asian working group for sarcopenia was used to assess whether a MHD patient had sarcopenia. Finally, 140 male (58 with possible sarcopenia or sarcopenia) and 102 female (65 with possible sarcopenia or sarcopenia) patients' data were collected. Participants were divided into sarcopenia and control groups for each sex to develop binary classifiers. After statistical analysis and feature selection, stratified shuffle split and Synthetic Minority Oversampling Technique were conducted and voting classifiers were developed. RESULTS: After eliminating handgrip strength, 6-m walk, and skeletal muscle index, the best three features for sarcopenia identification of male patients are age, fasting blood glucose, and parathyroid hormone. Meanwhile, age, arm without vascular access, total bilirubin, and post-dialysis creatinine are the best four features for females. After abandoning models with overfitting or bad performance, voting classifiers achieved good sarcopenia classification performance for both sexes (For males: sensitivity: 77.50% ± 11.21%, specificity: 83.13% ± 9.70%, F1 score: 77.32% ± 5.36%, the area under the receiver operating characteristic curves (AUC): 87.40% ± 4.41%. For females: sensitivity: 76.15% ± 13.95%, specificity: 71.25% ± 15.86%, F1 score: 78.04% ± 8.85%, AUC: 77.69% ± 7.92%). CONCLUSIONS: Two simple sex-specific sarcopenia identification tools for MHD patients were developed. They performed well on the case finding of sarcopenia, especially possible sarcopenia.

LightGBM: an efficient and accurate method for predicting pregnancy diseases.

As machine learning is becoming the fashion in disease prediction while no prediction model has performed very efficiently and accurately on predicting pregnancy diseases up to now, it's necessary to compare several common machine learning methods' performance on pregnancy diseases prediction and select out the best one. The data of two common pregnancy complications, pregnancy-induced hypertension (PIH) and Intrahepatic cholestasis of pregnancy (ICP), based on various maternal characteristics measured in patients' routine blood examination in 10-19 weeks of gestation are considered to be suitable to be learned. This is a retrospective study of 320 healthy pregnancies in 10-19 weeks, with 149 patients who subsequently developed PIH and 250 patients who subsequently developed ICP. Nine machine learning methods were used to predict PIH and ICP and their performance was compared via 8 evaluation indexes. Finally, the light Gradient Boosting Machine (lightGBM) is considered to be the best method to predict gestational diseases.Impact statementWhat is already known on this subject? As a kind of commonly used method in disease prediction, machine learning could be applied to clinical data for developing robust risk models and many achievements have been made. Also, machine learning can be used to predict pregnancy diseases. Although some machine learning methods have been used for screening gestational diseases, methods based on simple theories, such as logistic regression and decision tree, are frequently used. They don't always have a very satisfactory prediction results. Besides, only a few types of pregnancy diseases can be predicted.What do the results of this study add? LightGBM has the best prediction results of PIH and ICP among 9 machine learning methods in this study. It can predict PIH (AUC = 81.72%) with a sensitivity of 70.59%, and ICP (AUC = 95.91%) with a sensitivity of 97.91%.What are the implications of these findings for clinical practice and/or further research? A new model has been developed for effective first-trimester screening for two common pregnancy diseases, PIH and ICP. This lightGBM model can be used in relative hospitals and population of the research, and provide references for doctors' diagnosis and treatment of pregnant women. In further research, the predicted effect of lightGBM on daily practice and other pregnancy diseases such as pregnancy diabetes, will be verified.

A machine learning-based assistant tool for early frailty screening of patients receiving maintenance hemodialysis.

PURPOSE: To develop an assistant tool based on machine learning for early frailty screening in patients receiving maintenance hemodialysis. METHODS: This is a single-center retrospective study. 141 participants' basic information, scale results and laboratory findings were collected and the FRAIL scale was used to assess frailty. Then participants were divided into the frailty group (n = 84) and control group (n = 57). After feature selection, data split and oversampling, ten commonly used binary machine learning methods were performed and a voting classifier was developed. RESULTS: The grade results of Clinical Frailty Scale, age, serum magnesium, lactate dehydrogenase, comorbidity and fast blood glucose were considered to be the best feature set for early frailty screening. After abandoning models with overfitting or poor performance, the voting classifier based on Support Vector Machine, Adaptive Boosting and Naive Bayes achieved a good screening performance (sensitivity: 68.24% ± 8.40%, specificity:72.50% ± 11.81%, F1 score: 72.55% ± 4.65%, AUC:78.38% ± 6.94%). CONCLUSION: A simple and efficient early frailty screening assistant tool for patients receiving maintenance hemodialysis based on machine learning was developed. It can provide assistance on frailty, especially pre-frailty screening and decision-making tasks.