Can orange colour facilitate the processing of happiness? An exploration study on happiness metaphor.

Colour is a ubiquitous perceptual stimulus, and theoretical models of colour and psychological functioning posit that colour plays a key role in influencing the behaviour and mental function of a person. One investigation and two experiments investigated the colour metaphor representation of happiness concepts and the mapping mode of the colour metaphor of happiness concepts. A questionnaire was conducted to explore the relationship between colour preference and happiness. Study 2 shows that the identification of happiness words was facilitated more when words were viewed on an orange background than when viewed on a blue background. Study 3 further verifies the links of the connection between colour and happiness at the sentence level, and the orange-happiness facilitation effect was replicated. These results document a novel influence of colour on emotion recognition processes, where an orange background may facilitate the processing of the concept of happiness and provide support for conceptual metaphor theory and colour-in-context theory.

Effect of angiotensin receptor blockers on blood pressure and renal function in patients with concomitant hypertension and chronic kidney disease: a systematic review and meta-analysis.

Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or without diabetes.Methods: Literature search was performed in PubMed/MEDLINE, EMBASE and BIOSIS to identify parallel-group, randomized controlled trials (≥8 weeks) reporting the effects of ARB on office systolic/diastolic BP (SBP/DBP), estimated glomerular filtration rate (eGFR), serum creatinine (SCr), creatinine clearance (CrCl) or proteinuria in adults with hypertension and CKD. Mean difference (MD, generic inverse variance) with 95% confidence intervals (CIs) was used to report an outcome.Results: Among the 24 studies identified, 19 evaluated ARB as monotherapy, 4 evaluated ARB as combination therapy and one evaluated ARB both as monotherapy and combination therapy. Median (range) duration of the studies was 12 (1.84-54.0) months. ARB monotherapy significantly (p < 0.01) reduced BP (treatment ≥1 year: SBP [MD: -14.84 mmHg; 95% CI: -17.82 to -11.85]/DBP [-10.27 mmHg; -12.26 to -8.27]) and proteinuria (≥1 year [-0.90 g/L; -1.22 to -0.59]). Results were consistent for combination therapy. In these studies, non-significant changes were observed for eGFR, CrCl and SCr. The impact of SBP changes on eGFR was not significant; however, studies were of a relatively short duration.Conclusion: ARB had a favorable impact on BP and renal parameters such as proteinuria with monotherapy as well as with combination therapy, highlighting their potential benefits in patients with hypertension and CKD. During the short follow-up of these studies, no significant change in eGFR was observed.

Low-protein diet supplemented with ketoacids ameliorates proteinuria in 3/4 nephrectomised rats by directly inhibiting the intrarenal renin-angiotensin system.

Low-protein diet plus ketoacids (LPD+KA) has been reported to decrease proteinuria in patients with chronic kidney diseases (CKD). However, the mechanisms have not been clarified. As over-activation of intrarenal renin-angiotensin system (RAS) has been shown to play a key role in the progression of CKD, the current study was performed to investigate the direct effects of LPD+KA on intrarenal RAS, independently of renal haemodynamics. In this study, 3/4 subtotal renal ablated rats were fed 18 % normal-protein diet (Nx-NPD), 6 % low-protein diet (Nx-LPD) or 5 % low-protein diet plus 1 % ketoacids (Nx-LPD+KA) for 12 weeks. Sham-operated rats fed NPD served as controls. The level of proteinuria and expression of renin, angiotensin II (AngII) and its type 1 receptors (AT1R) in the renal cortex were markedly higher in Nx-NPD group than in the sham group. LPD+KA significantly decreased the proteinuria and inhibited intrarenal RAS activation. To exclude renal haemodynamic impact on intrarenal RAS, the serum samples derived from the different groups were added to the culture medium of mesangial cells. It showed that the serum from Nx-NPD directly induced higher expression of AngII, AT1R, fibronectin and transforming growth factor-ß1 in the mesangial cells than in the control group. Nx-LPD+KA serum significantly inhibited these abnormalities. Then, proteomics and biochemical detection suggested that the mechanisms underlying these beneficial effects of LPD+KA might be amelioration of the nutritional metabolic disorders and oxidative stress. In conclusion, LPD+KA could directly inhibit the intrarenal RAS activation, independently of renal haemodynamics, thus attenuating the proteinuria in CKD rats.

The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients.

Pulsed low-dose cyclophosphamide (CTX) therapy has become a very effective approach in improving the clinical outcomes of lupus nephritis (LN) patients. However, variations of CTX therapeutic outcomes in LN patients are incompletely understood. We investigated the contributions of known allelic variants to CTX therapy outcomes in 77 LN patients. Then, 22 out of the 77 patients were randomly enrolled to evaluate the pharmacokinetic profiles. LN patients with a GSTA1*A mutation (CT heterozygous) had more risk of non-remission (44% vs. 20%, P=0.005). Pharmacokinetic data indicated that patients with a GSTA1*A heterozygous variant had a lower exposure to 4-hydroxycyclophosphamide (4OHCTX) compared to wild-type patients (AUC4OHCTX: 12.8 (9.8, 19.5) vs. 27.5 (18.1, 32.8) h mg/l, P=0.023). Clinical remission was significantly related to higher exposure of 4OHCTX (P=0.038). In conclusion, LN patients with GSTA1*A heterozygous genotypes had poor CTX treatment remission due to less exposure to activated metabolites of CTX.

Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients?

Early versus later start of dialysis is still a matter of debate. Low-protein diets have been used for many decades to delay dialysis initiation. Protein-restricted diets (0.3-0.6 g protein/kg/day) supplemented with essential amino acids and ketoanalogues (sVLPD) can be offered, in association with pharmacological treatment, to motivated stage 4-5 chronic kidney disease (CKD) patients not having severe comorbid conditions; they probably represent 30-40% of the concerned population. A satisfactory adherence to such dietary prescription is observed in approximately 50% of the patients. While the results of the studies on the effects of this diet on the rate of progression of renal failure remain inconclusive, they are highly significant when initiation of dialysis is the primary outcome. The correction of uremic symptoms allows for initiation of dialysis treatment at a level of residual renal function lower than that usually recommended. Most of the CKD-associated complications of cardiovascular and metabolic origin, which hamper both lifespan and quality of life, are positively influenced by the diet. Lastly, with regular monitoring jointly assumed by physicians and dietitians, nutritional status is well preserved as confirmed by a very low mortality rate and by the absence of detrimental effect on the long-term outcome of patients once renal replacement therapy is initiated. On account of its feasibility, efficacy and safety, sVLPD deserves a place in the management of selected patients to safely delay the time needed for dialysis.

A cross-cultural comparison of teacher-student relationship quality in Chinese and Italian teachers and students.

Studies comparing teacher-student relationships between Eastern and Western countries are relatively rare. This study compared the affective qualities of teacher-student relationships between Eastern (i.e., China) and Western (i.e., Italy) countries to explore the measurement invariance, latent mean differences, and cultural differences in reporters' (teachers and students) agreement levels. An Italian sample of 31 teachers and 1647 students (46.9% girls; ages 9-14 years) and a Chinese sample of 28 teachers and 1474 students (44% girls; ages 9-14 years) reported on their perceptions of closeness and conflict in the teacher-student relationship. Measures of both student-perceived and teacher-perceived relationships achieved (partial) scalar invariance between the two cultures in the full sample, elementary school subsamples, and junior high school subsamples. Compared to their Chinese peers, the Italian junior high school students reported lower levels of conflict with their teachers, but there was no difference in closeness level. In addition, there was no difference in reporters' agreement across China and Italy in the full sample and in the junior high school subsample, whereas the Italian reporters' agreement on conflict was higher in the elementary school subsample.

Associations of resilience and respiratory sinus arrhythmia with alienation among college students.

BACKGROUND: Although the sense of alienation is harmful and causes many developmental problems, very few studies have focused on its antecedent variables and when these variables are related to alienation. The purpose of this study was to examine the relationship between resilience and sense of alienation among college students, and the moderating role of baseline respiratory sinus arrhythmia (RSA) in this association. METHOD: Physiological data were collected during a resting condition in the laboratory from 109 college students aged from 17 to 21 years (M = 18.94, SD = 0.92). Questionnaires that captured demographic information, resilience, and sense of alienation, were also completed. RESULTS: Results indicated that resilience was negatively related to the sense of alienation. Moreover, this negative relationship was moderated by baseline RSA such that it was significant only among students with low levels of baseline RSA. CONCLUSION: Our findings revealed that individuals with low resilience tend to have a higher level of alienation if their baseline RSA is relatively low. DISCUSSION: The current study sheds light on the psychological and biological characteristics of these individuals who tend to have higher levels of alienation, which may be useful for intervention program developers and practitioners.

Protein-restricted diets plus keto/amino acids--a valid therapeutic approach for chronic kidney disease patients.

Chronic kidney disease (CKD) is increasingly common, and there is an increasing awareness that every strategy should be used to avoid complications of CKD. Restriction of dietary protein intake has been a relevant part of the management of CKD for more than 100 years, but even today, the principal goal of protein-restricted regimens is to decrease the accumulation of nitrogen waste products, hydrogen ions, phosphates, and inorganic ions while maintaining an adequate nutritional status to avoid secondary problems such as metabolic acidosis, bone disease, and insulin resistance, as well as proteinuria and deterioration of renal function. This supplement focuses on recent experimental and clinical findings related to an optimized dietary management of predialysis, dialysis, and transplanted patients as an important aspect of patient care. Nutritional treatment strategies are linked toward ameliorating metabolic and endocrine disturbances, improving/maintaining nutritional status, as well as delaying the renal replacement initiation and improving outcomes in CKD patients. A final consensus states that dietary manipulations should be considered as one of the main approaches in the management program of CKD patients and that a reasonable number of patients with moderate or severe CKD benefit from dietary protein/phosphorus restriction.

China's country image in the eyes of international students from central Asian countries.

This study aimed to investigate the conceptualization and measurement of China's country image (CI) as well as its effects on the economic image, product image, national image and residence intention of individuals. A total of 297 international students from central Asia were recruited to complete an online survey. The confirmatory factor analysis of CI scale showed that CI is a multidimensional construct consisting of a cognitive component (further be divided into government image, international image, and social image) and an affective component. Participants' ratings on China's CIs before and after coming to China were compared by using a repeated-measures ANOVA and paired sample t-tests, and the results showed a significant difference in government image and international image but no significant difference in social image. The regression analysis showed that CI significantly predicted the economic image, product image, national image and individual's residence intention. This study demonstrated a theoretical insight of CI research and could potentially contribute to optimizing strategies to improve the country reputation.

Relational Victimization and Video Game Addiction among Female College Students during COVID-19 Pandemic: The Roles of Social Anxiety and Parasocial Relationship.

Video game addiction, a common behavioral problem among college students, has been more prominent during the COVID-19 pandemic; at the same time, females' video game usage has also attracted considerable research attention. Against this background and under the perspective of social interaction, this study aimed to examine the relationship between relational victimization and video game addiction among female college students, as well as its underlying mechanism-the mediating roles of social anxiety and parasocial relationships with virtual characters. Female college students (N = 437) were recruited to complete a set of questionnaires voluntarily in June 2022. Through the mediating effect analysis, the results found that (1) relational victimization was positively associated with female college students' video game addiction; (2) social anxiety and parasocial relationships with virtual characters could independently mediate this relation; (3) social anxiety and parasocial relationships with virtual characters were also the serial mediators in this association. These findings not only expand previous studies by revealing the social motivation of video game usage and the underlying mechanism accounting for video game addiction, but also provide basis and guidance for the prevention and intervention of video game addiction in the current context of the COVID-19 pandemic.

Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients.

AIM: To evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis (MHD) patients. METHODS: Forty MHD patients with uncontrolled hyperphosphatemia were randomized to either low DPI with keto acid-supplemented (sLP) or normal DPI (NP) group for 8 weeks. After 8 weeks, the sLP group was shifted to NP for another 8 weeks. Low-protein diet (LPD) was individualized with total caloric intake 30-35 kcal/kg/day, protein intake of 0.8 g/kg/day and phosphate intake of 500 mg/day. Keto acids were supplied in a dosage of 12 pills per day. Calcium phosphorous metabolism index and nutritional index (serum albumin, total protein, somatometric measurements, 3-day diaries and Mini-Nutritional Assessment score) were recorded. C-reactive protein, CO(2) combining power and Kt/V were measured to evaluate the inflammation, metabolic acidosis and dialysis adequacy, respectively. RESULTS: Serum phosphorus level and calcium-phosphate product were significantly decreased at the end of the first 8 weeks in the sLP group compared to the basal value and the NP group (p < 0.001). No difference was observed in C-reactive protein, Kt/V and nutritional index, while CO(2) combining power was significantly higher at week 8 in the sLP group (p < 0.001). CONCLUSION: Short-term restriction of DPI supplemented with keto acids could decrease hyperphosphatemia and calcium-phosphate product, while keeping stable nutritional status among MHD patients.

The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury.

BACKGROUND: Animal and human studies suggest that inflammation and malnutrition are common in acute kidney injury (AKI) patients. However, only a few studies reported CRP, a marker of inflammation, albumin, prealbumin and cholesterol, markers of nutritional status were associated with the prognosis of AKI patients. No study examined whether the combination of inflammatory and nutritional markers could predict the mortality of AKI patients. METHODS: 155 patients with hospital-acquired AKI were recruited to this prospective cohort study according to RIFLE (Risk, Injury, Failure, Lost or End Stage Kidney) criteria. C-reactive protein (CRP), and the nutritional markers (albumin, prealbumin and cholesterol) measured at nephrology consultation were analyzed in relation to all cause mortality of these patients. In addition, CRP and prealbumin were also measured in healthy controls (n = 45), maintenance hemodialysis (n = 70) and peritoneal dialysis patients (n = 50) and then compared with AKI patients. RESULTS: Compared with healthy controls and end-stage renal disease patients on maintenance hemodialysis or peritoneal dialysis, patients with AKI had significantly higher levels of CRP/prealbumin (p < 0.001). Higher level of serum CRP and lower levels of albumin, prealbumin and cholesterol were found to be significant in the patients with AKI who died within 28 days than those who survived >28 days. Similarly, the combined factors including the ratio of CRP to albumin (CRP/albumin), CRP/prealbumin and CRP/cholesterol were also significantly higher in the former group (p < 0.001 for all). Multivariate analysis (Cox regression) revealed that CRP/prealbumin was independently associated with mortality after adjustment for age, gender, sepsis and sequential organ failure assessment (SOFA, p = 0.027) while the others (CRP, albumin, prealbumin, cholesterol, CRP/albumin and CRP/cholesterol) became non-significantly associated. The hazard ratio was 1.00 (reference), 1.85, 2.25 and 3.89 for CRP/prealbumin increasing according to quartiles (p = 0.01 for the trend). CONCLUSIONS: Inflammation and malnutrition were common in patients with AKI. Higher level of the ratio of CRP to prealbumin was associated with mortality of AKI patients independent of the severity of illness and it may be a valuable addition to SOFA score to independent of the severity of illness and it may be a valuable addition to SOFA score to predict the prognosis of AKI patients.

The Moderating Role of Deviant Peer Affiliation in the Relation between Cyber-Victimization, Tobacco and Alcohol Use, and Age Differences.

Cyber-victimization, tobacco and alcohol use are all prominent public health problems among adolescents throughout the world. Against this background, this study examined the association between cyber-victimization and tobacco and alcohol use, as well as the moderating role of deviant peer affiliation and the potential age differences among elementary, middle, and high school students. A survey conducted among 1488 school students (aged 9-19 years, consisting of 702 elementary school students, 318 middle school students, and 468 high school students) found that cyber-victimization was positively correlated with tobacco and alcohol use among students of all stages. However, the moderating mechanism was different. Among elementary school students, deviant peer affiliation played a positive moderating role. For individuals with high deviant peer affiliation, this association was stronger. Among middle school students, the moderating role of deviant peer affiliation was insignificant. Among high school students, deviant peer affiliation played a negative moderating role; this association was significant for individuals with low deviant peer affiliation. The results of this study clarify the relationship between cyber-victimization and tobacco and alcohol use by examining the moderating role of deviant peer affiliation and age differences, providing intervention guidance for reducing the negative influences of cyber-victimization on children and adolescents with respect their use of tobacco and alcohol.

Student-teacher relationship quality and prosocial behaviour: The mediating role of academic achievement and a positive attitude towards school.

BACKGROUND: The current research investigated the association between teacher-student relationship (both teacher-perceived and student-perceived relationship quality) and students' prosocial behaviours, as well as the mediating roles of students' attitudes towards school and perceived academic competence in this association. SAMPLE: Four hundred and fifty-nine Italian primary students (aged 4-9, Mage  = 7.05, SDage  = 1.37) and 47 teachers (aged 26-60, Mage  = 48.35, SDage  = 8.13) participated and finished all the questionnaires and scales. METHODS: Multiple regression analyses and bootstrapping analyses were employed to test the direct and the mediating effects between the teacher/student-perceived relationship and students' prosocial behaviours. RESULTS: Results indicated that (1) teacher-student relationship was positively associated with students' prosocial behaviour; and (2) students' attitudes towards school could significantly mediate the association between teacher/student-perceived relationship and students' prosocial behaviours. CONCLUSIONS: Our understanding of how teacher-student relationship helps to enhance students' prosocial behaviours, as well as the intervention programmes that aim to enhance students' prosocial behaviours, may benefit from these findings.

Aldosterone promotes fibronectin synthesis in rat mesangial cells via ERK1/2-stimulated Na-H+ exchanger isoform 1.

BACKGROUND: Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathway involved. METHODS: We detected the expression of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 in rat glomeruli by immunochemistry and Western blot. Then the eukaryotic vectors of shRNA with insert targeting on NHE1 were successfully constructed and transfected into rat mesangial cells. The mRNA was quantified by real-time PCR. We measured the protein abundance of NHE1, ERK1/2 and phosphor-ERK1/2 by Western blot and the level of fibronectin by ELISA. RESULTS: First we demonstrated the local action of aldosterone on rat glomeruli in vivo. Then, after exposure to aldosterone, the NHE1 protein abundance was found increased in rat mesangial cells. Aldosterone treatment markedly increased the fibronectin level, which can be reduced by PD98059, spironolactone and shRNA-NHE1. PD98059 substantially reduced the aldosterone-induced NHE1 expression, while the knocking down of NHE1 did not alter aldosterone-stimulated phospho-ERK1/2 stimulation. CONCLUSION: The present study suggests that NHE1 may play an important role in aldosterone-mediated fibronectin accumulation in rat mesangial cells via the ERK1/2 pathway.

Angiopoietin-1 inhibits mouse glomerular endothelial cell senescence via Tie2 receptor-modulated ERK1/2 signaling.

BACKGROUND: The vasculature plays a key role in the progression of renal damage in aging, with reduction in glomerular and peritubular capillary density and decreased endothelial proliferative response. In this study, we examined the role of angiopoietin-1 (Ang1) in H(2)O(2)-induced senescence in mouse glomerular endothelial cells (MGECs) and the signaling pathway involved. METHODS: MGECs were subjected to H(2)O(2)-induced senescence, which was evaluated by senescence-associated beta-galactosidase (SA-beta-Gal) staining, cell cycle analysis and expression of p16. Endothelial cell function was assessed by nitric oxide, von Willebrand factor secretion and capillary-like structure formation. Signal transduction was examined by Western blot with or without a specific inhibitor. RESULTS: Ang1 significantly inhibited H(2)O(2)-induced senescence in MGECs, attenuated SA-beta-Gal activity, resumed growth, and downregulated p16(INK4a) levels. Moreover, Ang1 regulated the secretion and capillary-like structure formation of endothelial cells with aging. However, these changes were markedly blocked by treatment with Ang2, sTie2-Fc and PD98059. Ang1 treatment markedly increased elevated Tie2 and ERK1/2 phosphorylation levels which were reduced by Ang2 and sTie2-Fc. PD98059 substantially reduced senescence while not altering Ang1-stimulated phosphor-Tie2 stimulation. CONCLUSION: The present studies suggest that Ang1 inhibits H(2)O(2)-induced senescence in MGECs via the Ang1-Tie2-ERK1/2 signaling pathway.

Endothelial bioreactor ameliorates endotoxemia sepsis in swine.

INTRODUCTION: Severe sepsis involves a complex response including the activation of lots of cells, inflammatory mediators, and the hemostatic system. Central to this process is an alteration of endothelial cell function. Therefore, we investigated whether an endothelial bioreactor (EBR) would provide a new therapeutic approach to this clinical disorder. METHODS: EBR was constructed using a cartridge which contained with nonwoven polytetrafluoroethylene seeded with porcine iliac artery endothelial cell (PIEC). Pigs were intravenously administered with 0.25 mg/kg lipopolysaccharide and immediately placed in an extracorporeal circuit with EBR or sham controls. RESULTS: Compared with the sham group, EBR therapy resulted in significantly higher mean arterial blood pressure and significantly lower plasma von Willebrand factor, endothelin-1 and scores of lung injury. These alterations were associated with a significant survival advantage in the EBR group. CONCLUSIONS: Timely intervention with EC therapy in a tissue-engineered bioreactor may improve cardiovascular performance and alter the natural history of endotoxemia sepsis.

Mannitol is an independent risk factor of acute kidney injury after cerebral trauma: a case-control study.

We retrospectively studied a random cohort of patients with cerebral trauma to investigate the risk factors of acute kidney injury (AKI) following cerebral trauma. AKI was determined using the RIFLE (risk, injury, failure, loss, or end-stage kidney) staging criteria. About 171 patients were chosen in the study, with 53 patients in AKI group and 118 patients without AKI in non-AKI group. By logistic regression analysis, univariate analysis revealed that age, hypertension, emergent surgery, systemic inflammatory response syndrome (SIRS), Glasgow coma score (GCS), sequential organ failure assessment (SOFA) score, the respiration, coagulation, and cardiovascular components of the SOFA score, mechanical ventilation time, red blood cell transfusion, plasma transfusion, and the accumulative doses of furosemide, torsemide, and mannitol were significantly related to AKI after cerebral trauma. Logistic multivariate regression analysis showed that SOFA score [odds ratio (OR) = 1.516, 95% confidence interval (CI) 1.222-1.881, p < 0.001], the accumulative doses of torsemide (OR = 0.016, 95% CI 1.002-1.031, p = 0.016), and the accumulative doses of mannitol (OR = 2.687, 95% CI 1.062-6.800, p = 0.037) were independent risk factors of AKI. This model had a good discrimination for AKI with an area under the receiver operating characteristic (ROC) curve of 0.901 (p < 0.001). The accumulative doses of mannitol as a risk factor of AKI were identified by propensity score match (PSM) method. We concluded that AKI was a common complication in patients with cerebral trauma. SOFA score and the accumulative doses of torsemide and mannitol were independent risk factors of AKI following cerebral trauma.

Cyberbullying Victimization and Adolescent Depression: The Mediating Role of Psychological Security and the Moderating Role of Growth Mindset.

The objective of this study was to examine the mechanisms (the mediating role of psychological security and the moderating role of growth mindset) underlying the association between cyberbullying victimization and depression among adolescents. A sample of 755 adolescents (Mage = 13.35 ± 1.02; 373 boys) was recruited from two junior high schools, and the participants were asked to voluntarily complete a set of measures, including the cyberbullying victimization subscale in the Chinese version of the Cyberbullying Inventory, the Chinese version of the Security Questionnaire, the Chinese version of the Center for Epidemiologic Studies Depression Scale, and the Growth Mindset Inventory. The results indicated that: (1) cyberbullying victimization was positively associated with depression through the mediating effect of psychological security and (2) both the direct association between cyberbullying victimization and depression and the indirect association through the mediating effect of psychological security were moderated by growth mindset. Specifically, growth mindset could significantly alleviate the adverse effects of cyberbullying victimization on psychological security and on depression. These findings not only shed light on the mechanisms linking cyberbullying victimization to depression among adolescents, but also provide an empirical basis for formulating prevention and/or intervention programs aimed at reducing depression levels and the negative influences of cyberbullying victimization among adolescents.

Cyberbullying Victimization and Non-suicidal Self-Injurious Behavior Among Chinese Adolescents: School Engagement as a Mediator and Sensation Seeking as a Moderator.

Although a large body of research has indicated that cyberbullying victimization is a crucial risk factor for adolescent non-suicidal self-injury (NSSI) behavior, the mediating and moderating mechanisms underlying this relationship remain unclear. To address this research gap, this study, based on the social control theory and the organism-environment interaction model, was designed to test whether school engagement mediated the relationship between cyberbullying victimization and adolescent NSSI and whether this mediating effect was moderated by sensation seeking. A sample of 1,102 adolescents (M age = 13.17; SD = 0.69) anonymously completed the questionnaires. The results showed that the positive association between cyberbullying victimization and adolescent NSSI was mediated by school engagement. Moreover, this indirect link was significant for adolescents with high-level sensation seeking but non-significant for adolescents with low-level sensation seeking. These findings highlight school engagement as a potential mechanism linking cyberbullying victimization to adolescent NSSI, and high sensation seeking was an important risk factor to amplify this indirect effect. Intervention programs aimed at reducing NSSI among adolescents may benefit from the current research.