Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Structure and mechanisms of Escherichia coli aspartate transcarbamoylase.

Lipscomb, William N; Kantrowitz, Evan R.

Acc Chem Res ; 45(3): 444-53, 2012 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-22011033

2.

Boron atoms as spin carriers in two- and three-dimensional systems.

Kaim, Wolfgang; Hosmane, Narayan S; Zális, Stanislav; Maguire, John A; Lipscomb, William N.

Angew Chem Int Ed Engl ; 48(28): 5082-91, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19338002

3.

Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity.

Erion, Mark D; Dang, Qun; Reddy, M Rami; Kasibhatla, Srinivas Rao; Huang, Jingwei; Lipscomb, William N; van Poelje, Paul D.

J Am Chem Soc ; 129(50): 15480-90, 2007 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-18041833

4.

Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.

Dang, Qun; Kasibhatla, Srinivas Rao; Reddy, K Raja; Jiang, Tao; Reddy, M Rami; Potter, Scott C; Fujitaki, James M; van Poelje, Paul D; Huang, Jingwei; Lipscomb, William N; Erion, Mark D.

J Am Chem Soc ; 129(50): 15491-502, 2007 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-18041834

5.

The allosteric mechanism of yeast chorismate mutase: a dynamic analysis.

Kong, Yifei; Ma, Jianpeng; Karplus, Martin; Lipscomb, William N.

J Mol Biol ; 356(1): 237-47, 2006 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-16337651

6.

Recent Advances in Zinc Enzymology.

Lipscomb, William N.; Sträter, Norbert.

Chem Rev ; 96(7): 2375-2434, 1996 Nov 07.

Artigo em Inglês | MEDLINE | ID: mdl-11848831

7.

Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations.

Guo, Hong; Cui, Qiang; Lipscomb, William N; Karplus, Martin.

Angew Chem Int Ed Engl ; 42(13): 1508-11, 2003 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-12698486

8.

Proposed Boron Nanotubes.

Gindulyte, Asta; Lipscomb, William N.; Massa, Lou.

Inorg Chem ; 37(25): 6544-6545, 1998 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-11670779

9.

Quantum Chemical Calculations of Proposed Multicage Boron Fullerenes.

Gindulyte, Asta; Krishnamachari, Namby; Lipscomb, William N.; Massa, Lou.

Inorg Chem ; 37(25): 6546-6548, 1998 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-11670780

10.

Nature of "hydrogen bond" in the diborane-benzene complex: covalent, electrostatic, or dispersive?

Li, Hongzhi; Min, Donghong; Shore, Sheldon G; Lipscomb, William N; Yang, Wei.

Inorg Chem ; 46(10): 3956-9, 2007 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-17428045

11.

An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.

Busch, Silke; Schwier, Elke U; Nahlik, Krystyna; Bayram, Ozür; Helmstaedt, Kerstin; Draht, Oliver W; Krappmann, Sven; Valerius, Oliver; Lipscomb, William N; Braus, Gerhard H.

Proc Natl Acad Sci U S A ; 104(19): 8089-94, 2007 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-17470786

12.

T-state active site of aspartate transcarbamylase: crystal structure of the carbamyl phosphate and L-alanosine ligated enzyme.

Huang, Jingwei; Lipscomb, William N.

Biochemistry ; 45(2): 346-52, 2006 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-16401065

13.

Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae.

Helmstaedt, Kerstin; Strittmatter, Axel; Lipscomb, William N; Braus, Gerhard H.

Proc Natl Acad Sci U S A ; 102(28): 9784-9, 2005 Jul 12.

Artigo em Inglês | MEDLINE | ID: mdl-15987779

14.

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

Erion, Mark D; van Poelje, Paul D; Dang, Qun; Kasibhatla, Srinivas Rao; Potter, Scott C; Reddy, M Rami; Reddy, K Raja; Jiang, Tao; Lipscomb, William N.

Proc Natl Acad Sci U S A ; 102(22): 7970-5, 2005 May 31.

Artigo em Inglês | MEDLINE | ID: mdl-15911772

15.

Aspartate transcarbamylase (ATCase) of Escherichia coli: a new crystalline R-state bound to PALA, or to product analogues citrate and phosphate.

Huang, Jingwei; Lipscomb, William N.

Biochemistry ; 43(21): 6415-21, 2004 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-15157075

16.

Products in the T-state of aspartate transcarbamylase: crystal structure of the phosphate and N-carbamyl-L-aspartate ligated enzyme.

Huang, Jingwei; Lipscomb, William N.

Biochemistry ; 43(21): 6422-6, 2004 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-15157076

17.

Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase.

Helmstaedt, Kerstin; Heinrich, Gabriele; Lipscomb, William N; Braus, Gerhard H.

Proc Natl Acad Sci U S A ; 99(10): 6631-6, 2002 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-11997452

18.

Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.

Hartmann, Markus; Schneider, Thomas R; Pfeil, Andrea; Heinrich, Gabriele; Lipscomb, William N; Braus, Gerhard H.

Proc Natl Acad Sci U S A ; 100(3): 862-7, 2003 Feb 04.

Artigo em Inglês | MEDLINE | ID: mdl-12540830

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Structure and mechanisms of Escherichia coli aspartate transcarbamoylase.

Boron atoms as spin carriers in two- and three-dimensional systems.

Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity.

Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.

The allosteric mechanism of yeast chorismate mutase: a dynamic analysis.

Recent Advances in Zinc Enzymology.

Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations.

Proposed Boron Nanotubes.

Quantum Chemical Calculations of Proposed Multicage Boron Fullerenes.

Nature of "hydrogen bond" in the diborane-benzene complex: covalent, electrostatic, or dispersive?

An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.

T-state active site of aspartate transcarbamylase: crystal structure of the carbamyl phosphate and L-alanosine ligated enzyme.

Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae.

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

Aspartate transcarbamylase (ATCase) of Escherichia coli: a new crystalline R-state bound to PALA, or to product analogues citrate and phosphate.

Products in the T-state of aspartate transcarbamylase: crystal structure of the phosphate and N-carbamyl-L-aspartate ligated enzyme.

Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase.

Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.