Association of gestational metabolic syndrome with the Chinese Healthy Eating Index in mid-pregnancy: a cross-sectional study.

BACKGROUND: This study aims to investigate the relationship between gestational metabolic syndrome (GMS) and the Chinese Healthy Eating Index (CHEI) in mid-pregnancy, and to identify potentially beneficial or high-risk dietary habits. We have developed a mid-pregnancy version of CHEI-2022, adapting the Chinese Healthy Eating Index to align with the food quantity recommendations outlined in the 2022 Dietary Guidelines for Chinese Residents for mid-pregnancy. METHODS: Using the inclusion and exclusion criteria, data from 2411 mid-pregnant individuals were collected through interviews. The Total CHEI score and its component scores were determined through analysis of responses from the food frequency questionnaire. GMS diagnosis involved conducting physical examinations and performing blood biochemical tests. A logistic regression model was employed to analyze the relationship between GMS or related indices and both the total CHEI score and its component scores. RESULTS: The study identified an overall GMS prevalence of 21.65% (522 out of 2411 participants). During mid-pregnancy, participants diagnosed with GMS exhibited higher BMI, FBG, 1hPBG, 2hPBG, TC, TG, HDL, SBP, as well as higher educational levels and daily activity, compared to those without GMS (P < 0.001). After adjusting for potential confounders, participants with higher total CHEI scores (≥ 80) were found to have lower odds of GMS or related indices (P < 0.05). Increasing dietary intake of potatoes, whole grains, beans, dark green vegetables, and fruits, as per the CHEI recommendations, was associated with reduced odds of GMS or related indices (P < 0.05). CONCLUSION: A high-quality diet, as indicated by a total CHEI score of 80 or higher, and increased consumption of specific dietary components, namely potatoes, beans, dark green vegetables, and fruits, were found to effectively reduce the odds of GMS or related indices during mid-pregnancy.

Diversity and seasonal abundance of Culicoides (Diptera, Ceratopogonidae) in Shizong County, Yunnan Province, China.

Culicoides (Diptera, Ceratopogonidae) are small biting midges, some of which are vectors for animal associated arboviruses such as bluetongue virus (BTV) and Akabane virus (AKAV). BTV and AKAV are both pathogenic for livestock, with BTV in particular posing a major threat to domestic ruminants. Ongoing problems with BTV in ruminants in Shizong County of Yunnan Province, China, promoted a year-long investigation of the Culicoides in Shizong to determine relative abundance and seasonality of midges and to attempt to identify species that might be acting as vectors in the area. Culicoides were collected by UV light trap for one night per week for most weeks between May 2020 and May 2021. More than 21,000 specimens consisting of at least 21 species belonging to six subgenera and one unplaced group, including 5 species previously associated with BTV and one associated with AKAV, were collected. Culicoides tainanus dominated most collections throughout the year although C. sumatrae was often the dominant species over summer. Most species were abundant between May and October. These results indicate that C. tainanus, C. jacobsoni and C. oxystoma are the major midge pests of livestock in Shizong and should be considered in any disease investigation.

Title: Diversité et abondance saisonnière des Culicoides (Diptera, Ceratopogonidae) dans le comté de Shizong, province du Yunnan, Chine. Abstract: Les culicoïdes (Diptera, Ceratopogonidae) sont de petits moucherons piqueurs, dont certains sont des vecteurs d'arbovirus associés aux animaux tels que le virus de la fièvre catarrhale du mouton (FCMV) et le virus Akabane (AKAV). Le FCMV et l'AKAV sont tous deux pathogènes pour le bétail, le FCMV en particulier constituant une menace majeure pour les ruminants domestiques. Les problèmes persistants de FCMV chez les ruminants dans le comté de Shizong de la province du Yunnan, en Chine, ont encouragé une enquête d'un an sur les Culicoides à Shizong pour déterminer l'abondance relative et la saisonnalité des culicoïdes et tenter d'identifier les espèces qui pourraient agir comme vecteurs dans la région. Les culicoïdes ont été collectés par piège à lumière UV une nuit par semaine pendant la plupart des semaines entre mai 2020 et mai 2021. Plus de 21 000 spécimens comprenant au moins 21 espèces appartenant à six sous-genres et un groupe non placé, dont 5 espèces précédemment associées au FCMV et une associée à l'AKAV, ont été collectés. Culicoides tainanus a dominé la plupart des collectes tout au long de l'année bien que C. sumatrae ait souvent été l'espèce dominante pendant l'été. La plupart des espèces étaient abondantes entre mai et octobre. Ces résultats indiquent que C. tainanus, C. jacobsoni et C. oxystoma sont les principaux culicoïdes nuisibles pour le bétail à Shizong et devraient être pris en compte dans toute enquête épidémiologique.

Oncogenic role of Tc17 cells in cervical cancer development.

BACKGROUND: As one of the subsets of CD8+ T cells, Tc17 cells have recently been identified and are characterized by the secretion of interleukin (IL)-17, which is related to inflammatory diseases. AIM: To assess the status of Tc17 cells in cervical cancer and investigate the biological function of Tc17 cells in cervical cancer development. METHODS: Flow cytometry assay, immunohistochemistry, and immunofluorescence were performed to detect the levels and phenotype of Tc17 cells in blood and tumor samples from patients with cervical cancer. Prior to cell suspension culture, ELISA was carried out to measure the production of IL-6, IL-1ß, IL-23, CXCL12, and IL-17 in tumor tissue supernatant and co-cultured supernatant of patients with cervical cancer. In addition, multivariate analysis was performed to identify factors associated with overall survival using the Cox proportional hazards model. RESULTS: Compared with normal tissues, Tc17 cells specifically accumulated in tumor tissues of cervical cancer patients. Cancer cells produced a greater amount of IL-6, IL-1ß, and IL-23, which in turn promoted Tc17 cell polarization. Unlike the traditional cytotoxic CD8+ T cells, Tc17 cells secreted IL-17, which subsequently promoted CXCL12 expression in tumor cells, eventually enhancing the proliferation and migration of tumor cells. Thus, the ratio of tumor-infiltrating Tc17 cells was highly correlated with poor clinical outcome in patients with cervical cancer. CONCLUSION: Our data identified the oncogenic role of Tc17 cells in the development of cervical cancer. We propose that the ratio of Tc17 cells may be a useful index in the prognosis of patients with cervical cancer.