Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Low-frequency inherited complement receptor variants are associated with purpura fulminans.

Bendapudi, Pavan K; Nazeen, Sumaiya; Ryu, Justine; Söylemez, Onuralp; Robbins, Alissa; Rouaisnel, Betty; O'Neil, Jillian K; Pokhriyal, Ruchika; Yang, Moua; Colling, Meaghan; Pasko, Bryce; Bouzinier, Michael; Tomczak, Lindsay; Collier, Lindsay; Barrios, David; Ram, Sanjay; Toth-Petroczy, Agnes; Krier, Joel; Fieg, Elizabeth; Dzik, Walter H; Hudspeth, James C; Pozdnyakova, Olga; Nardi, Valentina; Knight, James; Maas, Richard; Sunyaev, Shamil; Losman, Julie-Aurore.

Blood ; 143(11): 1032-1044, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38096369

2.

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.

McBrayer, Samuel K; Olenchock, Benjamin A; DiNatale, Gabriel J; Shi, Diana D; Khanal, Januka; Jennings, Rebecca B; Novak, Jesse S; Oser, Matthew G; Robbins, Alissa K; Modiste, Rebecca; Bonal, Dennis; Moslehi, Javid; Bronson, Roderick T; Neuberg, Donna; Nguyen, Quang-De; Signoretti, Sabina; Losman, Julie-Aurore; Kaelin, William G.

Proc Natl Acad Sci U S A ; 115(16): E3741-E3748, 2018 04 17.

Artigo em Inglês | MEDLINE | ID: mdl-29610306

3.

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

Losman, Julie-Aurore; Kaelin, William G.

Genes Dev ; 27(8): 836-52, 2013 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-23630074

4.

Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism.

Al-Samkari, Hanny; Snyder, Gregory D; Nikiforow, Sarah; Tolaney, Sara M; Freedman, Rachel A; Losman, Julie-Aurore.

J Med Genet ; 56(1): 39-42, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30287596

5.

Cancer therapy: The leukaemia epigenome targeted.

Losman, Julie-Aurore.

Nature ; 543(7647): 634-635, 2017 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-28358070

6.

Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability.

Gunn, Kathryn; Losman, Julie-Aurore.

Cold Spring Harb Perspect Med ; 14(5)2024 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-38191174

7.

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.

Gunn, Kathryn; Myllykoski, Matti; Cao, John Z; Ahmed, Manna; Huang, Bofu; Rouaisnel, Betty; Diplas, Bill H; Levitt, Michael M; Looper, Ryan; Doench, John G; Ligon, Keith L; Kornblum, Harley I; McBrayer, Samuel K; Yan, Hai; Duy, Cihangir; Godley, Lucy A; Koivunen, Peppi; Losman, Julie-Aurore.

Cancer Discov ; 13(6): 1478-1497, 2023 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-36847506

8.

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma.

Cleary, James M; Rouaisnel, Betty; Daina, Antoine; Raghavan, Srivatsan; Roller, Lauren A; Huffman, Brandon M; Singh, Harshabad; Wen, Patrick Y; Bardeesy, Nabeel; Zoete, Vincent; Wolpin, Brian M; Losman, Julie-Aurore.

NPJ Precis Oncol ; 6(1): 61, 2022 Sep 02.

Artigo em Inglês | MEDLINE | ID: mdl-36056177

9.

Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.

Chen, Hsiao-Yun; Durmaz, Yavuz T; Li, Yixiang; Sabet, Amin H; Vajdi, Amir; Denize, Thomas; Walton, Emily; Laimon, Yasmin Nabil; Doench, John G; Mahadevan, Navin R; Losman, Julie-Aurore; Barbie, David A; Tolstorukov, Michael Y; Rudin, Charles M; Sen, Triparna; Signoretti, Sabina; Oser, Matthew G.

Nat Commun ; 13(1): 4998, 2022 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-36008402

10.

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.

Shi, Diana D; Savani, Milan R; Levitt, Michael M; Wang, Adam C; Endress, Jennifer E; Bird, Cylaina E; Buehler, Joseph; Stopka, Sylwia A; Regan, Michael S; Lin, Yu-Fen; Puliyappadamba, Vinesh T; Gao, Wenhua; Khanal, Januka; Evans, Laura; Lee, Joyce H; Guo, Lei; Xiao, Yi; Xu, Min; Huang, Bofu; Jennings, Rebecca B; Bonal, Dennis M; Martin-Sandoval, Misty S; Dang, Tammie; Gattie, Lauren C; Cameron, Amy B; Lee, Sungwoo; Asara, John M; Kornblum, Harley I; Mak, Tak W; Looper, Ryan E; Nguyen, Quang-De; Signoretti, Sabina; Gradl, Stefan; Sutter, Andreas; Jeffers, Michael; Janzer, Andreas; Lehrman, Mark A; Zacharias, Lauren G; Mathews, Thomas P; Losman, Julie-Aurore; Richardson, Timothy E; Cahill, Daniel P; DeBerardinis, Ralph J; Ligon, Keith L; Xu, Lin; Ly, Peter; Agar, Nathalie Y R; Abdullah, Kalil G; Harris, Isaac S; Kaelin, William G.

Cancer Cell ; 40(9): 939-956.e16, 2022 09 12.

Artigo em Inglês | MEDLINE | ID: mdl-35985343

11.

2-Oxoglutarate-dependent dioxygenases in cancer.

Losman, Julie-Aurore; Koivunen, Peppi; Kaelin, William G.

Nat Rev Cancer ; 20(12): 710-726, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33087883

12.

Spontaneous hemorrhage after external ventricular drain placement in the setting of low factor VII secondary to liver cirrhosis.

Chua, Melissa Ming Jie; Das, Alvin S; Losman, Julie Aurore; Patel, Nirav J; Izzy, Saef.

Surg Neurol Int ; 11: 403, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-33365166

13.

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.

Christian, Sven; Merz, Claudia; Evans, Laura; Gradl, Stefan; Seidel, Henrik; Friberg, Anders; Eheim, Ashley; Lejeune, Pascale; Brzezinka, Krzysztof; Zimmermann, Katja; Ferrara, Steven; Meyer, Hanna; Lesche, Ralf; Stoeckigt, Detlef; Bauser, Marcus; Haegebarth, Andrea; Sykes, David B; Scadden, David T; Losman, Julie-Aurore; Janzer, Andreas.

Leukemia ; 33(10): 2403-2415, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-30940908

14.

Targeting Aberrant Signaling in Myeloid Malignancies: Promise Versus Reality.

Sellar, Rob; Losman, Julie-Aurore.

Hematol Oncol Clin North Am ; 31(4): 565-576, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28673388

15.

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Elf, Shannon; Abdelfattah, Nouran S; Chen, Edwin; Perales-Patón, Javier; Rosen, Emily A; Ko, Amy; Peisker, Fabian; Florescu, Natalie; Giannini, Silvia; Wolach, Ofir; Morgan, Elizabeth A; Tothova, Zuzana; Losman, Julie-Aurore; Schneider, Rebekka K; Al-Shahrour, Fatima; Mullally, Ann.

Cancer Discov ; 6(4): 368-81, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26951227

16.

Cases from the Osler Medical Service at Johns Hopkins University. Diagnosis: P. carinii pneumonia and primary pulmonary sporotrichosis.

Losman, Julie-Aurore; Cavanaugh, Kerri.

Am J Med ; 117(5): 353-6, 2004 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-15336585

17.

Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate.

Bendapudi, Pavan K; Robbins, Alissa; LeBoeuf, Nicole; Pozdnyakova, Olga; Bhatt, Ami; Duke, Fujiko; Sells, Ryan; McQuiston, John; Humrighouse, Ben; Rouaisnel, Betty; Colling, Meaghan; Stephenson, Kathryn E; Saavedra, Arturo; Losman, Julie-Aurore.

Blood Adv ; 2(21): 2917-2921, 2018 11 13.

Artigo em Inglês | MEDLINE | ID: mdl-30396911

18.

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman, Julie-Aurore; Looper, Ryan E; Koivunen, Peppi; Lee, Sungwoo; Schneider, Rebekka K; McMahon, Christine; Cowley, Glenn S; Root, David E; Ebert, Benjamin L; Kaelin, William G.

Science ; 339(6127): 1621-5, 2013 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-23393090

19.

A bleeding heart.

Goldberg, Jenna; Losman, Julie-Aurore; Cavanaugh, Kerri.

Am J Med ; 119(12): 1029-32, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17145243

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