RESUMO
BACKGROUND: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. AIM: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. PATIENTS AND METHODS: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare-up of healed patch test reactions to chamomile. RESULTS: None of the subjects had a flare-up of healed patch test reactions. According to the NRS, SLM-positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules. CONCLUSION: No evidence suggestive of systemic allergic dermatitis was found.
Assuntos
Dermatite Alérgica de Contato/etiologia , Ingestão de Alimentos , Dermatoses da Mão/etiologia , Matricaria/efeitos adversos , Preparações de Plantas/efeitos adversos , Adulto , Idoso , Estudos de Casos e Controles , Dermatite Alérgica de Contato/fisiopatologia , Método Duplo-Cego , Feminino , Dermatoses da Mão/fisiopatologia , Humanos , Lactonas/efeitos adversos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Preparações de Plantas/administração & dosagem , Distribuição Aleatória , Sesquiterpenos/efeitos adversosRESUMO
Patients with contact allergy to sesquiterpene lactones (SLs) are usually hypersensitive to Asteraceae plant products such as herbal teas. The objective of this study was to show sensitizers in chamomile tea by patch testing with thin-layer chromatograms. Tea made from German chamomile was separated by thin-layer chromatography. Strips of the thin-layer chromatograms were used for patch testing SL-positive patients. 15 (43%) of 35 patients tested positively to 1 or more spots on the thin-layer chromatogram, with many individual reaction patterns. Patch testing with thin-layer chromatograms of German chamomile tea showed the presence of several allergens.
Assuntos
Alérgenos , Camomila , Dermatite Alérgica de Contato/etiologia , Lactonas/efeitos adversos , Sesquiterpenos/efeitos adversos , Chá , Adulto , Idoso , Estudos de Casos e Controles , Cromatografia em Camada Fina , Dermatite Alérgica de Contato/diagnóstico , Feminino , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Testes do EmplastroRESUMO
Contact allergy to herbal teas derived from the Asteraceae plant family was investigated in patients allergic to sesquiterpene lactones (SLs). 20 patients with a known contact allergy to SLs were recalled and patch tested with aqueous extracts of 8 different herbal teas based on Asteraceae plants as well as with parthenolide and other SLs. In 18 of 20 patients with SL allergy, there were positive test reactions to the Asteraceae teas, mainly to those based on German chamomile, dandelion and wormwood. Among the SLs, parthenolide was the most frequent co-reactor. Obviously, most patients with a contact allergy to SLs are allergic to commercial teas derived from the Asteraceae plant family as well.