Detalhe da pesquisa
1.
Resistance Analysis of Bictegravir-Emtricitabine-Tenofovir Alafenamide in HIV-1 Treatment-Naive Patients through 48 Weeks.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803969
2.
Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator.
Br J Clin Pharmacol
; 83(2): 370-380, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27552251
3.
A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
J Infect Dis
; 209(2): 275-84, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24123773
4.
Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.
Drug Metab Dispos
; 41(7): 1414-24, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620487
5.
Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.
Drug Metab Dispos
; 41(12): 2056-65, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23785064
6.
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.
Drug Metab Dispos
; 40(1): 159-68, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22010218
7.
Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.
Drug Metab Dispos
; 40(3): 426-35, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106171
8.
Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.
Chem Res Toxicol
; 25(11): 2285-300, 2012 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22823924
9.
Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19.
Clin Pharmacol Ther
; 109(4): 1116-1124, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501997
10.
Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.
Clin Pharmacol Ther
; 109(1): 55-64, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32460379
11.
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.
Clin Pharmacokinet
; 60(5): 569-583, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33782830
12.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Clin Pharmacol Ther
; 109(5): 1334-1341, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33141923
13.
Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition.
Biochim Biophys Acta Gen Subj
; 1864(4): 129531, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31953125
14.
Safety, pharmacokinetics and pharmacodynamics of selgantolimod, an oral Toll-like receptor 8 agonist: a Phase Ia study in healthy subjects.
Antivir Ther
; 25(3): 171-180, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667286
15.
Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin.
Clin Pharmacol Ther
; 104(6): 1182-1190, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29569723
16.
Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine.
Clin Pharmacol Ther
; 104(6): 1191-1198, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29569712
17.
Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
FEBS Lett
; 590(16): 2527-35, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27416800
18.
Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Pharmacogenomics
; 15(16): 1947-62, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25521354
19.
In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors.
Expert Opin Drug Metab Toxicol
; 8(4): 449-66, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22384784
20.
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
Biochem Pharmacol
; 83(1): 149-63, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22020119