Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.

Kumar, Suresh; Javed, Ruheena; Mudd, Michal; Pallikkuth, Sandeep; Lidke, Keith A; Jain, Ashish; Tangavelou, Karthikeyan; Gudmundsson, Sigurdur Runar; Ye, Chunyan; Rusten, Tor Erik; Anonsen, Jan Haug; Lystad, Alf Håkon; Claude-Taupin, Aurore; Simonsen, Anne; Salemi, Michelle; Phinney, Brett; Li, Jing; Guo, Lian-Wang; Bradfute, Steven B; Timmins, Graham S; Eskelinen, Eeva-Liisa; Deretic, Vojo.

Cell ; 184(24): 5950-5969.e22, 2021 11 24.

Artigo em Inglês | MEDLINE | ID: mdl-34741801

2.

TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy.

Kaur, Namrita; de la Ballina, Laura Rodriguez; Haukaas, Håvard Styrkestad; Torgersen, Maria Lyngaas; Radulovic, Maja; Munson, Michael J; Sabirsh, Alan; Stenmark, Harald; Simonsen, Anne; Carlsson, Sven R; Lystad, Alf Håkon.

EMBO J ; 42(17): e113105, 2023 09 04.

Artigo em Inglês | MEDLINE | ID: mdl-37409525

3.

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.

Radulovic, Maja; Wenzel, Eva Maria; Gilani, Sania; Holland, Lya Kk; Lystad, Alf Håkon; Phuyal, Santosh; Olkkonen, Vesa M; Brech, Andreas; Jäättelä, Marja; Maeda, Kenji; Raiborg, Camilla; Stenmark, Harald.

EMBO J ; 41(24): e112677, 2022 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-36408828

4.

Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy.

Corkery, Dale P; Nadeem, Aftab; Aung, Kyaw Min; Hassan, Ahmed; Liu, Tao; Cervantes-Rivera, Ramón; Lystad, Alf Håkon; Wang, Hui; Persson, Karina; Puhar, Andrea; Simonsen, Anne; Uhlin, Bernt Eric; Wai, Sun Nyunt; Wu, Yao-Wen.

J Cell Sci ; 134(5)2021 02 23.

Artigo em Inglês | MEDLINE | ID: mdl-33106317

5.

The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1.

Hamaoui, Daniel; Cossé, Mathilde M; Mohan, Jagan; Lystad, Alf Håkon; Wollert, Thomas; Subtil, Agathe.

Proc Natl Acad Sci U S A ; 117(43): 26784-26794, 2020 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-33055216

6.

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.

Herhaus, Lina; Bhaskara, Ramachandra M; Lystad, Alf Håkon; Gestal-Mato, Uxía; Covarrubias-Pinto, Adriana; Bonn, Florian; Simonsen, Anne; Hummer, Gerhard; Dikic, Ivan.

EMBO Rep ; 21(1): e48317, 2020 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-31709703

7.

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

Lystad, Alf Håkon; Ichimura, Yoshinobu; Takagi, Kenji; Yang, Yinjie; Pankiv, Serhiy; Kanegae, Yumi; Kageyama, Shun; Suzuki, Mariko; Saito, Izumu; Mizushima, Tsunehiro; Komatsu, Masaaki; Simonsen, Anne.

EMBO Rep ; 15(5): 557-65, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24668264

8.

Assays to monitor aggrephagy.

Lystad, Alf Håkon; Simonsen, Anne.

Methods ; 75: 112-9, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25555675

9.

The separate axes of TECPR1 and ATG16L1 in CASM.

Kaur, Namrita; Carlsson, Sven R; Lystad, Alf Håkon.

Autophagy ; 20(1): 214-215, 2024 01.

Artigo em Inglês | MEDLINE | ID: mdl-37676042

10.

The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.

Herzog, Laura K; Kevei, Éva; Marchante, Ricardo; Böttcher, Claudia; Bindesbøll, Christian; Lystad, Alf Håkon; Pfeiffer, Annika; Gierisch, Maria E; Salomons, Florian A; Simonsen, Anne; Hoppe, Thorsten; Dantuma, Nico P.

Aging Cell ; 19(1): e13051, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31625269

11.

Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery.

Lystad, Alf Håkon; Simonsen, Anne.

Cells ; 8(9)2019 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-31450711

12.

Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes.

Lystad, Alf Håkon; Carlsson, Sven R; Simonsen, Anne.

Autophagy ; 15(8): 1485-1486, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31122169

13.

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes.

Lystad, Alf Håkon; Carlsson, Sven R; de la Ballina, Laura R; Kauffman, Karlina J; Nag, Shanta; Yoshimori, Tamotsu; Melia, Thomas J; Simonsen, Anne.

Nat Cell Biol ; 21(3): 372-383, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30778222

14.

Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.

Kauffman, Karlina J; Yu, Shenliang; Jin, Jiaxin; Mugo, Brian; Nguyen, Nathan; O'Brien, Aidan; Nag, Shanta; Lystad, Alf Håkon; Melia, Thomas J.

Autophagy ; 14(6): 992-1010, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29458288

15.

Phosphoinositide-binding proteins in autophagy.

Lystad, Alf Håkon; Simonsen, Anne.

FEBS Lett ; 590(15): 2454-68, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27391591

16.

HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels.

Holland, Petter; Knævelsrud, Helene; Søreng, Kristiane; Mathai, Benan J; Lystad, Alf Håkon; Pankiv, Serhiy; Bjørndal, Gunnveig T; Schultz, Sebastian W; Lobert, Viola H; Chan, Robin B; Zhou, Bowen; Liestøl, Knut; Carlsson, Sven R; Melia, Thomas J; Di Paolo, Gilbert; Simonsen, Anne.

Nat Commun ; 7: 13889, 2016 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-28004827

17.

TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy.

Isakson, Pauline; Lystad, Alf Håkon; Breen, Kamilla; Koster, Gerbrand; Stenmark, Harald; Simonsen, Anne.

Autophagy ; 9(12): 1955-64, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24128730

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Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.

TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy.

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.

Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy.

The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1.

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

Assays to monitor aggrephagy.

The separate axes of TECPR1 and ATG16L1 in CASM.

The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.

Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery.

Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes.

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes.

Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.

Phosphoinositide-binding proteins in autophagy.

HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels.

TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy.