Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.

The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drug-eluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.

Emerging Methods of Monitoring Volatile Organic Compounds for Detection of Plant Pests and Disease.

Each year, unwanted plant pests and diseases, such as Hendel or potato soft rot, cause damage to crops and ecosystems all over the world. To continue to feed the growing population and protect the global ecosystems, the surveillance and management of the spread of these pests and diseases are crucial. Traditional methods of detection are often expensive, bulky and require expertise and training. Therefore, inexpensive, portable, and user-friendly methods are required. These include the use of different gas-sensing technologies to exploit volatile organic compounds released by plants under stress. These methods often meet these requirements, although they come with their own set of advantages and disadvantages, including the sheer number of variables that affect the profile of volatile organic compounds released, such as sensitivity to environmental factors and availability of soil nutrients or water, and sensor drift. Furthermore, most of these methods lack research on their use under field conditions. More research is needed to overcome these disadvantages and further understand the feasibility of the use of these methods under field conditions. This paper focuses on applications of different gas-sensing technologies from over the past decade to detect plant pests and diseases more efficiently.

The impact of a short-period head-down tilt on executive function in younger adults.

Microgravity has been shown to be a significant stressor on the cardiovascular system and the brain due to the redistribution of fluids that occurs in the absence of gravitational force, but there is scarce literature surrounding the effects of microgravity on cerebral hemodynamics and cognition. Understanding the early effects that simulated gravity has on cognitive function is essential for developing proper physical and cognitive countermeasures to assure safe and effective cognitive/decisions making while astronauts prepare for the initial launch or when they arrive in a microgravity environment. Therefore, this study aims to determine how an acute simulation of microgravity would alter cerebral oxygenation and executive functions. Sixty-five young healthy participants (22 ± 6 years, 21 females) completed a thirty (30) minute horizontal (00 tilt) followed by a 90-min - 6° head-down-tilt (HDT) protocol. Cerebral oxygenation in the prefrontal cortex was monitored throughout the testing session using near-infrared spectroscopy. Cognition was also measured using a computerized Stroop Task. Our results demonstrate that cerebral oxygenation was higher during HDT compared to the horizontal supine position (9.11 ± 1.3 vs. 7.51 ± 1.8, p = 0.02). For the cognitive results, the non-executive performance of the Stroop task remained stable during HDT (652.46 ± 19.3 vs. 632.49 ± 14.5, p = 0.09). However, reaction time during the executive task performance was improved after the HDT (1058 ± 195-950 ± 158 ms, p < 0.01). Our results suggest that an acute bout of simulated microgravity can enhance executive functioning.