Characterizing the supra- and subsolidus processes that generated the Current PGE-Cu-Ni deposit, Thunder Bay North Intrusive Complex, Canada: insights from trace elements and multiple S isotopes of sulfides.

The Current deposit is hosted by serpentinized peridotite that intruded rocks of the Quetico Subprovince in the Midcontinent Rift, and is subdivided into three morphologically distinct regions - the shallow and thin Current-Bridge Zone in the northwest, the deep and thick 437-Southeast Anomaly (SEA) Zone in the southeast, and the thick Beaver-Cloud Zone in the middle. The magma parental to the Current deposit became saturated in sulfide as a result of the addition of external S from at least two sources - a deep source characterized by high Δ33S (< 3‰) values, and a shallow source, potentially the Archean metasedimentary country rocks, characterized by low Δ33S (< 0.3‰). Variations in Δ33S-S/Se-Cu/Pd values indicate that the contamination signatures were largely destroyed by interaction of the sulfide liquid with large volumes of uncontaminated silicate melt. The intrusion crystallized sequentially, with the Current-Bridge Zone crystallizing first, followed by the Beaver-Cloud Zone, and lastly by the 437-SEA Zone. This, along with the elevated Cu/Pd ratios in the 437-SEA Zone, which formed as a result of sulfide segregation during an earlier saturation event, and development of igneous layering in this zone, suggests that it represents the feeder channel to the Current deposit. After the intrusion crystallized, the base-metal sulfide mineralogy was modified by circulation of late-stage hydrothermal fluids, with pyrrhotite and pentlandite being replaced by pyrite and millerite, respectively. This fluid activity mobilized metals and semi-metals, including Fe, Ni, S, Se, Co, Cu, Ag, and As, but did not affect the PGE. This contribution highlights the importance of the interplay between magma dynamics and magmatic-hydrothermal processes in the formation of Ni-Cu-PGE-mineralized deposits. Supplementary Information: The online version contains supplementary material available at 10.1007/s00126-023-01193-9.

Activity of gonadotrophin surge-attenuating factor during the luteal phase in superovulated women.

Gonadotrophin surge-attenuating factor (GnSAF) is a putative nonsteroidal ovarian factor that attenuates the luteinizing hormone (LH) surge in superovulated women. GnSAF bioactivity was studied during the luteal phase by investigating six normally ovulating women in two cycles--a spontaneous and a follicle-stimulating hormone (FSH)-treated cycle. In both cycles, the pituitary response to an acute intravenous injection (10 micrograms) of luteinizing-hormone-releasing hormone (LHRH) was investigated in late follicular (follicle size 16 mm), early luteal (day 5 after human chorionic gonadotrophin, hCG), midluteal (day 9 after hCG) and late luteal phase (day 12 or 13 after hCG). FSH was injected daily at the dose of 225 iu on cycle days 2, 3 and 4, and 150 iu thereafter. The increase in LH and FSH (mean +/- SEM) 30 min after LHRH in the spontaneous cycles decreased significantly from early to late luteal phase and remained unchanged in the FSH-treated cycles. Increases in LH and FSH 30 min after LHRH were significantly attenuated in the FSH-treated compared with the spontaneous cycles in late follicular and luteal phases. Serum oestradiol and progesterone concentrations were significantly higher in the FSH than in the spontaneous cycles only in early, but not in mid- and late luteal phase. The pattern of serum oestradiol and progesterone changes during the luteal phase did not correlate with the increases in LH and FSH 30 min after hCG both in the spontaneous and the FSH cycles. These results suggest that GnSAF bioactivity is high during the luteal phase of superovulated cycles.