1.
Infection
; 49(4): 757-762, 2021 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33825125
RESUMO
Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
Assuntos
COVID-19/imunologia , Monócitos/imunologia , SARS-CoV-2/fisiologia , Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico/sangue , Idoso , Feminino , Hospitalização , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Índice de Gravidade de Doença , Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico/biossíntese , Regulação para Cima
2.
Am J Respir Crit Care Med
; 207(2): e1-e3, 2023 01 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36174190