Clara cell 10 (CC10) protein attenuates allergic airway inflammation by modulating lung dendritic cell functions.

Allergic asthma is a complex inflammatory disorder predominantly orchestrated by T helper 2 (Th2) lymphocytes. The anti-inflammatory protein Clara Cell 10-kDa (CC10), also known as secretoglobin family 1A member 1 (SCGB1A1), shows promise in modulating respiratory diseases. However, its precise role in asthma remains unclear. This study examines the potential of CC10 to suppress allergic asthma inflammation, specifically assessing its regulatory effects on Th2 cell responses and dendritic cells (DCs). Lower CC10 levels in asthma were observed and correlated with increased IgE and lymphocytes. Cc10-/- mice exhibited exacerbated allergic airway inflammation marked by increased inflammatory cell infiltration, Th2 cytokines, serum antigen-specific IgE levels, and airway hyperresponsiveness (AHR) in house dust mite (HDM)-induced models. Conversely, recombinant CC10 significantly attenuated these inflammatory responses. Intriguingly, CC10 did not directly inhibit Th cell activation but significantly downregulated the population of CD11b+CD103- DCs subsets in lungs of asthmatic mice and modulated the immune activation functions of DCs through NF-κB signaling pathway. The mixed lymphocyte response assay revealed that DCs mediated the suppressive effect of CC10 on Th2 cell responses. Collectively, CC10 profoundly mitigates Th2-type allergic inflammation in asthma by modulating lung DC phenotype and functions, highlighting its therapeutic potential for inflammatory airway conditions and other related immunological disorders.

The complete mitochondrial genome of Neptunea arthritica cumingii Crosse, (Gastropoda: Buccinidae).

The complete mitochondrial (mt) genome of the Neptune whelk, Neptunea arthritica cumingii, was determined using genome walking techniques in this study. The total length of the mt genome sequence of N. arthritica cumingii was 15 256 bp, including 13 protein-coding genes, 21 transfer RNA genes and 2 ribosomal RNA genes. The overall composition of the mitogenome was estimated to be 30.85% for A, 38.59% for T, 15.15% for C and 15.40% for G, indicating that an A + T (69.44%)-rich feature occurs in the N. arthritica cumingii mitogenome. The phylogenetic relationships of 11 mollusc species were constructed based on the complete mtDNA sequences by the neighbour-joining method using MEGA 5.0 software (MEGA Inc., Englewood, NJ).