An electrogram-guided transvenous temporary pacemaker implant simulator.

INTRODUCTION: Transvenous temporary pacemaker (TvTP) implantation is a critical procedure often performed under time limitations, playing a crucial role in patient survival. However, the amount of training provided for resident cardiologists is variable, due to the availability of patients. Thus, the use of simulators for this cardiologic procedure could be used as training tools. OBJECTIVE: The present study aimed to develop a simulator system for TvTP implantation based on electrograms, called ETTIS (Electrogram-guided Transvenous Temporary-pacemaker Implantation Simulator), and to evaluate its educational potential and cardiology residents' perceived learning efficacy as a training tool. METHODOLOGY: The development of the ETTIS involved three stages: (1) Adaptation of an anatomical mannequin; (2) Design and manufacture of electronic circuits and software capable of identifying the catheter contact site within the heart chambers and reproducing electrograms in both surfaces (mode-on) and intracavitary (mode-off); (3) To evaluate its educational potential, a modified Likert questionnaire was administered to nine cardiology experts. Additionally, to evaluate the perceived learning efficacy, another modified Likert questionnaire was given to six cardiology residents both before and after training with the ETTIS. Descriptive statistics with measures of position and dispersion were employed, and the weighted Kappa test was used for agreement analysis. RESULTS: A high rate of acceptance (over 90%) was found among experts who evaluated the ETTIS. The cardiology residents showed significant self-perceived learning gains, as evidenced by a lack of agreement between their responses to a questionnaire before and after training. CONCLUSION: The ETTIS is a promising tool for medical training, displaying both educational potential and efficacy. It has been shown to be effective in learning a variety of skills, including cardiac catheterization and electrophysiology. Additionally, the ETTIS is highly engaging and allows cardiology residents to practice in a safe and controlled environment.

Aryl thiosemicarbazones: In vitro and immunomodulatory activities against L. amazonensis.

Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells, leishmanicidal activity and immunomodulatory potential of seven aryl thiosemicarbazones. Host cell cytotoxicity was determined in peritoneal macrophages of BALB/c mouse, antiparasitic activity was determined against promastigotes and amastigotes of WHOM/00LTB 0016 strain of L. amazonensis. Nitric oxide (NO) production, interleukin (IL)-12, IL-10 and TNF-alpha secretion were measured in the supernatant of uninfected and infected macrophage cultures. It was observed that aryl thiosemicarbazones presented in vitro antiparasitic activity against both extracellular and intracellular forms of L. amazonensis. However, unlike Amphotericin B, these compounds displayed low cytotoxicity towards host cells. In addition to observed antiparasitic activity, compounds exhibited modulatory properties in the secretion of cytokines and nitrite content from uninfected stimulated and L. amazonensis-infected macrophages. In conclusion, we demonstrated the in vitro antiparasitic activity against L. amazonensis for aryl thiosemicarbazones, which is possible achieved by Th1 cytokine profile modulation. These findings are potential useful for drug development against cutaneous leishmaniasis.

A Grid Connected Photovoltaic Inverter with Battery-Supercapacitor Hybrid Energy Storage.

The power generation from renewable power sources is variable in nature, and may contain unacceptable fluctuations, which can be alleviated by using energy storage systems. However, the cost of batteries and their limited lifetime are serious disadvantages. To solve these problems, an improvement consisting in the collaborative association of batteries and supercapacitors has been studied. Nevertheless, these studies don't address in detail the case of residential and large-scale photovoltaic systems. In this paper, a selected combined topology and a new control scheme are proposed to control the power sharing between batteries and supercapacitors. Also, a method for sizing the energy storage system together with the hybrid distribution based on the photovoltaic power curves is introduced. This innovative contribution not only reduces the stress levels on the battery, and hence increases its life span, but also provides constant power injection to the grid during a defined time interval. The proposed scheme is validated through detailed simulation and experimental tests.

A Smart Power Electronic Multiconverter for the Residential Sector.

The future of the grid includes distributed generation and smart grid technologies. Demand Side Management (DSM) systems will also be essential to achieve a high level of reliability and robustness in power systems. To do that, expanding the Advanced Metering Infrastructure (AMI) and Energy Management Systems (EMS) are necessary. The trend direction is towards the creation of energy resource hubs, such as the smart community concept. This paper presents a smart multiconverter system for residential/housing sector with a Hybrid Energy Storage System (HESS) consisting of supercapacitor and battery, and with local photovoltaic (PV) energy source integration. The device works as a distributed energy unit located in each house of the community, receiving active power set-points provided by a smart community EMS. This central EMS is responsible for managing the active energy flows between the electricity grid, renewable energy sources, storage equipment and loads existing in the community. The proposed multiconverter is responsible for complying with the reference active power set-points with proper power quality; guaranteeing that the local PV modules operate with a Maximum Power Point Tracking (MPPT) algorithm; and extending the lifetime of the battery thanks to a cooperative operation of the HESS. A simulation model has been developed in order to show the detailed operation of the system. Finally, a prototype of the multiconverter platform has been implemented and some experimental tests have been carried out to validate it.

Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid.

Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study. Patients were randomized into two groups: Group I was treated with NASHA (Durolane®) and Group II with HA (Go-ON®). Patient's evolution was followed up at the 1st, 2nd, 4th, 8th, 12th, and 26th week after treatment. A statistically significant improvement in WOMAC score was observed for patients treated with NASHA versus those who received HA at Week 26. In addition, the need for analgesia was significantly reduced at Week 26 in the NASHA-treated group. Finally, the economic analysis showed an increased cost of overall treatment with HA injections. Our data support the use of the NASHA class of products in the treatment of knee OA.

Recent environmental and morphosedimentary evolution of the mining-impacted Nalón Estuary (Asturias, N Spain): Disentangling natural and anthropogenic processes.

Distinguishing between natural and anthropogenic processes in sedimentary records from estuaries with legacy pollutants is an essential task, as it provides baselines to predict future environmental trajectories of coastal areas. Here, we have addressed the recent transformation history of the mining-impacted Nalón Estuary (Asturias, N Spain). Surface and core sediment records from marshes and tidal flats were examined through a broad multidisciplinary approach, involving micropaleontological (benthic foraminifera), sedimentological (grain-size), geochemical (trace metals, major element Al and total organic carbon), physical (magnetic susceptibility, frequency-dependent magnetic susceptibility and large microplastics) and radioisotopic (210Pb, 137Cs and 239+240Pu) proxies. Results suggest that the interplay between natural (high fluvial influence and extreme hydrological events) and anthropogenic (coal and mercury mining disposals) factors induced strong sedimentation-erosion processes, further shaping the recent evolution of the estuary. Short-time scale and intense sedimentation processes were revealed by overall high sediment accumulation rates, the dilution of some geological signatures and the rapid formation of a marsh in the lower estuary bay. The increasing mining fingerprints during the 20th century were shortly interrupted by the catastrophic riverine flooding of 1938. Conversely, current erosional processes by fluvial influence led to the remobilization of contaminated sedimentary materials and exposure of mining-legacy Hg levels in tidal flats from the middle sector. Fluvial activity, floodings and taphonomic biases exerted a major control on benthic foraminifera since the 19th century, although Hg ecotoxicological effects on modern assemblages at certain areas within the estuary cannot be discarded. These findings, along with the documented enhanced erosion of marshes with 'trapped' pollutants (Hg, coal microparticles and microplastics), highlight the importance of monitoring the environmental and geomorphic processes taking place in historically-contaminated estuaries.

Synthesis, ADMET Prediction, and Antitumor Profile of Phenoxyhydrazine- 1,3-thiazoles Derivatives.

BACKGROUND: Cancer is one of the most important barriers to increasing life expectancy in all countries in the 21st century. Investigations of new anti-cancer drugs with low side effects are an urgent demand for medicinal chemists. Considering the known antitumor and immunomodulatory activity of thiazoles, this work presents the synthesis and antineoplastic activity of new thiazoles. METHODS: The 22 new compounds (2a-v) were synthesized from different thiosemicarbazones and 2-bromoacetophenone. The compounds were evaluated on: MOLT-4, HL-60, HL-60/MX1, MM1S, SKMEL-28, DU145, MCF-7, and T47d. RESULTS: Compound 2b induced cellular viability on MOLT-4 (37.1%), DU145 (41.5%), and HL- 60/MX1 (58.8%) cells. On MOLT-4 cells, compound 2b exhibited an IC50 of 8.03 µM, and against DU145 cells, an IC50 of 6.04µM. Besides, at IC50 and fold of IC50, 20% to 30% of dead cells were found, most due to necrosis/late apoptosis. Most compounds no showed cytotoxicity against fibroblast cells L929 at the concentrations tested. The compound did not alter the cell cycle of DU145 cells when compared to the negative control. Therefore, compound 2b stands out against DU145 and MOLT-4 cells. CONCLUSION: Our study reinforced the importance of 1,3-thiazoles nuclei in antitumor activity. In addition, derivative 2b stands out against DU145 and MOLT-4 cells and could be a starting point for developing new antineoplastic agents.

Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications.

PURPOSE: In ST-segment elevation myocardial infarction (STEMI) patients, longitudinal strain (LS) in remote non-infarcted myocardium (RNM) has not yet been characterized by tissue tracking (TT) cardiovascular magnetic resonance (CMR). In STEMI patients, we aimed to characterize RNM-LS by TT-CMR and to assess both its dynamics and its structural and prognostic implications. METHODS: We recruited 271 patients with a first STEMI studied with TT-CMR 1 week after infarction. Of these patients, 145 underwent 1-week and 6-month TT-CMR and were used to characterize both the dynamics and the short-term and long-term structural implications of RNM-LS. Based on previously validated data, RNM areas were defined depending on the culprit coronary artery. RESULTS: Reduced RNM-LS at 1 week (n = 70, 48%) was associated with larger infarct size and more depressed left ventricular ejection fraction (LVEF) at both the 1-week and 6-month TT-CMR (p value < 0.001). Late normalization of RNM-LS was frequent (28/70, 40%) and independently related to late recovery of LVEF (p value = 0.002). Patients with reduced RNM-LS at 1-week TT-CMR had more major adverse cardiac events (death, heart failure or re-infarction) in both the 271 patients included in the study group (26% vs. 11%, p value = 0.002) and in an external validation cohort made up of 177 STEMI patients (57% vs. 13%, p value < 0.001). CONCLUSION: After STEMI, reduced RNM-LS by TT-CMR is common and is associated with more severe short- and long-term structural damage. There is a beneficial tendency towards recovery of RNM-LS that parallels late recovery of LVEF. More events occur in patients with reduced RNM-LS.

A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds.

BACKGROUND: Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health. OBJECTIVE: This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process. METHODS: Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review were based on the guidelines mentioned in the PRISMA statement. Moreover, the assessment of the methodological quality of the selected studies was also performed. RESULTS: From a total of 3018 studies, 16 studies were included in this paper based on our eligibility criteria, which showed promising and consistent results. CONCLUSION: Further research concerning specific inflammatory conditions is required.

Lipid Nanoparticles as a Skin Wound Healing Drug Delivery System: Discoveries and Advances.

Chronic wounds are a remarkable cause of morbidity, requiring long-time treatments with a significant impact on the quality of life and high costs for public health. Although there are a variety of topical skin preparations commercially available, they have several limitations that frequently impair wound healing, such as drug instability, toxicity, limited time of action and ineffective skin permeation. In recent years, researchers have focused on the development of new effective treatments for wound healing and shown frequent interest in nanometric drug delivery systems to overcome such obstacles. In dermatology, lipid nanoparticles (LNPs) have received great attention from researchers due to their great functionalities, greater adhesion to the skin and film formation, enabling the hydration and maintenance of skin integrity, as well as present a more effective penetration through the skin barrier. This review provides an update on topical formulations based on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as wound healing treatments. Both SLNs and NLCs are able to increase solubility and stability of active pharmaceutical ingredients and increase skin penetration compared to the free drugs. Additionally, SLNs and NLCs can increase pharmacological activity, increase the release profile of the drugs, promote synergistic effects and improve the sensory properties of the final formulation. Topical dosage forms containing nanoparticles have been extensively evaluated for wound healing activity, mainly the dressings, films and scaffolds. Therefore, lipid nanoparticles have contributed in improving wound healing therapies when incorporated into other dosage forms with better efficacy and lesser adverse effects than conventional formulations.

Environmental regeneration processes in the Anthropocene: The Bilbao estuary case (northern Spain).

This work tackles a multidisciplinary study on the recent sedimentary record of the Bilbao estuary (northern Spain), which is the backbone of a city that was primarily industrial and now is widely recognized as a successful example of urban transformation. Although hotspots of heavily polluted materials still remain at the mouth of the two main tributaries (Galindo and Gobelas), the data obtained confirm the ongoing formation of a new layer of sediments (here called "postindustrial zone") covering historically polluted and azoic deposits. It is characterized by largely variable levels of metals and magnetic susceptibility and moderate-to-high abundances of benthic foraminifera. Monitoring of the evolution of this layer appears a key factor to assess environmental improvement and decision-making in polluted estuaries.

COMPARATIVE ANALYSIS OF SURGICAL HEMOSTATIC SPONGES IN LIVER INJURY: STUDY IN RATS.

BACKGROUND: Obtaining effective hemostasis either in the traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge. AIM: Comparative study between the use of different hemostatic sponges in hepatic wound and their capacity of integration to cells in a short period. METHODS: Fifteen Wistar rats were divided into three groups. Through laparotomy a standardized wound in hepatic right lobe was made. The animals were treated with three sponges, being gelatin in group I, equine collagen in group II, and oxidized cellulose in group III. The hemostatic capacity was analysed. On the 7º day after surgery samples for histology analysis (H&E and picrosirius) were collected for inflammatory evaluation and collagen quantification (types I and III) with polarized microscopy. RESULTS: All materials used had similar haemostatic effects, with no significant difference in hemostasis time. In the assessment of tissue repair and adhesions provoked, as well as analysis of the inflammatory process, the gelatin sponge presented greater inflammation and adhesions to the contiguous structures to the procedure in relation to the other groups. CONCLUSION: Animals which had their wounds treated with collagen and regenerated cellulose sponges presented better results in relationship to the ones treated with gelatin sponge.

Comparative analysis of surgical hemostatic sponges in liver injury: study in rats / Análise comparativa de esponjas hemostáticas cirúrgicas em ferimento de fígado: estudo em ratos

ABSTRACT Background Obtaining effective hemostasis either in the traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge. Aim: Comparative study between the use of different hemostatic sponges in hepatic wound and their capacity of integration to cells in a short period. Methods: Fifteen Wistar rats were divided into three groups. Through laparotomy a standardized wound in hepatic right lobe was made. The animals were treated with three sponges, being gelatin in group I, equine collagen in group II, and oxidized cellulose in group III. The hemostatic capacity was analysed. On the 7º day after surgery samples for histology analysis (H&E and picrosirius) were collected for inflammatory evaluation and collagen quantification (types I and III) with polarized microscopy. Results: All materials used had similar haemostatic effects, with no significant difference in hemostasis time. In the assessment of tissue repair and adhesions provoked, as well as analysis of the inflammatory process, the gelatin sponge presented greater inflammation and adhesions to the contiguous structures to the procedure in relation to the other groups. Conclusion: Animals which had their wounds treated with collagen and regenerated cellulose sponges presented better results in relationship to the ones treated with gelatin sponge.

RESUMO Racional A obtenção de hemostasia eficaz nas lesões traumáticas ou cirúrgicas de vísceras parenquimatosas, em especial do fígado, sempre foi desafiante. Objetivo: Comparar o uso de hemostáticos absorvíveis em ferimento hepático quanto à capacidade hemostática e de integração aos tecidos em curto prazo. Métodos: Foram utilizados 15 ratos Wistar separados em três grupos. Foi realizada laparotomia e ferimento padronizado em lobo hepático direito. Os animais do grupo I foram tratados com esponja de gelatina sobre os ferimentos; os do grupo II com esponja de colágeno equino, e os do grupo III com celulose regenerada oxidada. Na ocasião foi estudada a capacidade hemostática. No 7º dia de pós-operatório nova laparotomia foi realizada e foram coletadas amostras para estudos histológicos (H&E e picrosirius) avaliando os processos por microscopia ótica e de polarização para quantificação de colágeno (tipos I e III). Resultados: Todos os materiais usados apresentaram efeitos hemostáticos semelhantes, não havendo diferença significativa no tempo de hemostasia. Na avaliação da reparação tecidual e aderências provocadas, assim como análise do processo inflamatório, os tratados com esponja de gelatina apresentaram maior inflamação e aderências às estruturas contíguas ao procedimento em relação aos outros grupos. Conclusão: Os animais tratados com a esponja de colágeno e celulose regenerada apresentaram resultados melhores que aqueles com esponja de gelatina.

Estudo do reparo do ferimento de colon com o lado seroso da parede de jejuno, utilizando cianoacrilato e cola de fibrina / Study of repair of rat's colon wound whith serosal of jejunal wall using cyanoacrylate and fibrin glue

OBJETIVO: Comparar o efeito do cianoacrilato e da cola de fibrina como adesivo das bordas do ferimento de cólon reparado com o lado seroso da parede de jejuno. MÉTODO: Foram utilizados 45 ratos wistar adultos jovens, machos , com peso médio de 260 gramas procedentes do Biotério Central da Universidade Estadual de Maringá.Os animais foram submetidos a procedimento operatório sob sedação com thiopental para produção de ferimento pradonizado de 0,5 cm distante caudalmente a 2 cm do ceco que foi reparado no grupo I pelo lado seroso da parede de jejuno e sutura, no grupo II, pelo lado seroso da parede de jejuno e cola de fibrina, e o grupo III pelo lado seroso da parede de jejuno e cianoacrilato. No 4° dia de pós-operatório os animais foram submetidos a um enema opaco, para estudo o de estenose. No 7° dia de pós-operatório os animais foram submetidos a laparotomia sob sedação para estudo macroscópico da cavidade , e coleta dos segmentos que foram processados para análise microscópica. RESULTADOS: A cola de fibrina teve uma tendência de ser melhor reparadora, estimulando a proliferação de fibras de colágeno a partir da borda da ferida. CONCLUSÃO: O experimento demonstrou que o ferimento em cólon de rato pode ser reparado pelo lado seroso da parede de jejuno colado às bordas da ferida por cola de fibrina ou cianoacrilato.

Estudo comparativo do tratamento de ferimento de colon de coelho com reparo seroso da parede de jejunum e sutura primária / Comparative study of colon wound treatment of rabbits using serosal repair of jejunal wall and primary suture

Os animais foram submetidos a procedimento operatório sob anestesia geral para a produção de dois ferimentos padronizados em colo não preparado, usando instrumento desenvolvido para esta finalidade. O primeiro ferimento foi produzido a 2 cm do ceco e o segundo 20 cm eqüidistante deste, no sentido caudal. Estes ferimentos foram reparados obedecendo a resultado de sorteio que determinou a técnica a ser usada, se com o lado seroso da parede de jejuno ou por sutura primária. Nas duas técnicas foram usados pontos separados de fio monofilamentar de poliglecaprone 4-0 , sendo que o animal serviu de controle para si mesmo. Realizou-se eutanásia no 7º P.O. para os animais do sub-grupo A e no 30º P.O. para os animais do sub-grupo B para avaliação macroscópica e microscópica. O experimento demonstrou que é viável o uso do lado seroso da parede de jejuno para reparar ferimento em colo não preparado e apresentou resultados com tendências a serem superiores aos da sutura primária , não dual de Maringá.

Estudo comparativo do uso de cola de fibrina e cianoacrilato em ferimento de fígado de rato / The repair of liver experimental wound with fibrin glue and cianoacrilate

OBJETIVO: estudar comparativamente o uso de cianoacrilato e cola de fibrina no reparo do ferimento hepático, para evidenciar suas respectivas capacidades de integração aos tecidos à curto prazo. MÉTODOS: 30 ratos Wistar-EPM1 foram separados em 2 grupos e submetidos à anestesia com tiopental na concentração de 40mg/kg EV. Realizada laparotomia com exposição do fígado. Usando um "punch" dermatológico de 3mm foi produzido um ferimento padronizado em lobo direito hepático. Os animais do grupo A foram tratados com a colocação de cola de fibrina nos ferimentos, os animais do grupo B tiveram os ferimentos tratados com adesivo de cianoacrilato. No 7º de PO, sob anestesia, os animais sofreram a ressecção do lobo hepático direito e foram coletadas amostras para os procedimentos de estudo histológicos (HE e Picro-Sirius). Foram avaliados, por microscopia óptica, os processos inflamatórios (critérios qualitativos da presença de neutrófilos, células gigantes, granuloma tipo corpo estranho, neovascularização) e, por microscopia de polarização, a quantificação de colágeno (Tipo I-jovem e Tipo III-maduro). RESULTADOS: Os dois adesivos levaram ao efeito hemostático em tempos semelhantes. Os ferimentos tratados com cola de fibrina mostraram maior quantidade de colágeno jovem e maduro e uma maior quantidade de neovascularização, enquanto os ferimentos tratados com cianoacrilato mostraram maior reação de granuloma tipo corpo estranho. CONCLUSÃO: O ferimento tratado com a cola de fibrina apresentou maior neovascularização e maior porcentagem de colágeno tipo I e tipo III demonstrando tendência a uma melhor reparação tecidual, sem formação de granuloma tipo corpo estranho.

Aferição da temperatura da glicose utilizada na crioescleroterapia / Gauging the temperature of the glucose used in the cryoesclerotherapy

Objetivo: Realizar a aferição da temperatura da glicose 75 por cento, usada como agente esclerosante na crioescleroterapia. Método: Utilizando-se um aparelho Termopar tipo T, foram realizadas várias medidas da temperatura em 12 amostras de glicose, considerando-se diferentes locais para aferição, tais como interior da cápsula refrigerada como neve carbônica, dois locais no interior da seringa que continha o esclerosante, na glicose que saía da seringa e da agulha. Tais medidas foram realizadas em 1, 10, 20 e 30 minutos. Resultados: Nas amostras da glicose 75 por cento no interior da base da seringa do conjunto utilizado para crioescleroterapia, a temperatura foi de menos40graus centígrados, mas nesse local havia formação de cristais, o que impossibilitava sua utilização...

Anastomose intestinal eversora: uso experimental de sutura mecânica simples / Everted intestinal anastomosis: experimental use of simple mechanic suture

Este estudo foi efetuado para confirmar a eficiência e os aspectos técnicos de uma anastomose intestinal no cäo, utilizando-se um grampeador de sutura cutânea. Em 6 cäes foram realizados anastomoses jejunais e colônicas eversoras. Em cada cäo, a anastomose foi realizada com a coloraçäo de grampos metálicos, utilizando-se um grampeador cutâneo tipo Proximate. Os cäes foram sacrificados com 1, 3 e 6 semanas após a cirurgia. Cada anastomose foi examinada macro e microscopicamente. Todos os cäes sobreviveram, sem complicaçöes. Os estudos macroscópico e microscópico mostraram cicatrizaçäo satisfatória nos diferentes intervalos de pós-operatório e grande extensäo de aderências serosas ao nível das anastomoses

Abscesso amebiano de fígado: tratamento através da punçäo percutânea dirigida pela ultrassonografia / Amebic liver abscess: treatment by percutaneous neede puncture guided by ultrasound

Um caso de abscesso amebiano de fígado tratado através da punçäo percutânea, com aspiraçäo e drenagem é apresentado. O diagnóstico e a punçäo foram realizados com o auxílio da ultrassonografia. Para manter a drenagem foi utilizado um cateter de "Intracath". Foi associado ao tratamento metronidazol na dosagem de 2 g/dia vía oral