Detalhe da pesquisa
1.
Regulation of GTPase function by autophosphorylation.
Mol Cell
; 82(5): 950-968.e14, 2022 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35202574
2.
Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.
Protein Expr Purif
; 212: 106361, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37652393
3.
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
Proc Natl Acad Sci U S A
; 117(22): 12101-12108, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32414921
4.
The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.
Angew Chem Int Ed Engl
; 62(18): e202218698, 2023 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36883374
5.
NMR in integrated biophysical drug discovery for RAS: past, present, and future.
J Biomol NMR
; 74(10-11): 531-554, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32804298
6.
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
Mol Cell
; 45(5): 642-55, 2012 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22405273
7.
A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.
Int J Mol Sci
; 21(8)2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32326637
8.
Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angew Chem Int Ed Engl
; 59(27): 11037-11045, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32227412
9.
Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.
Plant Cell
; 28(7): 1738-51, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335451
10.
Hitting the hotspots.
Nat Chem Biol
; 18(6): 578-579, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314815
11.
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
J Am Chem Soc
; 140(13): 4473-4476, 2018 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29543440
12.
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc Natl Acad Sci U S A
; 112(21): 6625-30, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25941399
13.
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).
J Biol Chem
; 291(30): 15641-52, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226556
14.
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J Biol Chem
; 289(18): 12195-201, 2014 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24648513
15.
Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum.
Biochem Biophys Res Commun
; 460(1): 5-21, 2015 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25998729
16.
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc Natl Acad Sci U S A
; 109(16): 6078-83, 2012 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474372
17.
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.
Cell Mol Life Sci
; 70(21): 3989-4008, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307074
18.
Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.
Protein Sci
; 33(6): e5016, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38747381
19.
Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol
; 103(2): 151414, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38640594
20.
Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.
J Am Chem Soc
; 135(9): 3367-70, 2013 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23409921