Factors associated with antibody titer levels among an occupational cohort of fully vaccinated individuals and subsequent risk of COVID-19 infection: A cohort study.

This study (1) determined the association of time since initial vaccine regimen, booster dose receipt, and COVID-19 history with antibody titer, as well as change in titer levels over a defined period, and (2) determined risk of COVID-19 associated with low titer levels. This observational study used data from staff participating in the National Football League COVID-19 Monitoring Program. A cohort of staff consented to antibody-focused sub-study, during which detailed longitudinal data were collected. Among all staff in the program who received antibody testing, COVID-19 incidence following antibody testing was determined. Five hundred eighty-six sub-study participants completed initial antibody testing; 80% (469) completed follow-up testing 50-101 days later. Among 389 individuals who were not boosted at initial testing, the odds of titer < 1000 AU/mL (vs. ≥1000 AU/mL) increased 44% (odds ratio [OR] = 1.44, 95% confidence interval [CI]: 1.18-1.75) for every 30 days since final dose. Among 126 participants boosted before initial testing with no COVID-19 history, 125 (99%) had a value > 2500 AU/ml; 86 (96%) of 90 tested at follow-up and did not develop COVID-19 in the interim remained at that value. One thousand fifty-seven fully vaccinated (330 [29%] boosted at antibody test) individuals participating in the monitoring program were followed to determine COVID-19 status. Individuals with titer value < 1000 AU/mL had twice the risk of COVID-19 as those with >2500 AU/mL (HR = 2.02, 95% CI: 1.28-3.18). Antibody levels decrease postvaccination; boosting increases titer values. While antibody level is not a clear proxy for infection immunity, lower titer values are associated with higher COVID-19 incidence, suggesting increased protection from boosters.

Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties.

INTRODUCTION: There are many intra-articular hyaluronic acid (IA-HA) products on the market that have known intrinsic differences in molecular size, source, and structure. The current review summarizes existing evidence describing and assessing these differences, while also identifying whether these differences have an impact on clinical outcomes. METHODS: This systematic review summarized all literature that specifically addresses IA-HA product differences. Included studies summarized basic science and mechanism of action comparisons of IA-HA product differences, or systematic reviews that assess differences in clinical outcomes between IA-HA product differences. RESULTS: A total of 20 investigations assessed basic science differences between IA-HA products, while 20 investigations provided assessments of the clinical outcome differences between IA-HA product characteristics. The published basic science literature provided a differentiation between low molecular weight (LMW) and high molecular weight (HMW) HA with regard to changes within the synovial fluid, driven by the interactions that these molecules have with receptors in the joint space. These differences in receptor interaction manifest within clinical outcomes, as meta-analyses comparing pain relief after IA-HA suggest that pain reduction is superior in patients who receive HMW HA as opposed to LMW HA. CONCLUSION: This review highlights differences between IA-HA characteristics, and how important the molecular weight, derivation of the product, and structure are to variances in reported clinical outcomes to treat osteoarthritis (OA) of the knee. HMW IA-HAs have shown greater efficacy compared to the alternative of LMW products, while avian-derived and cross-linked products have potentially demonstrated an increase in inflammatory events over non-avian-derived, non-cross-linked HAs.

Seventy-five percent of National Football League teams use pregame hyperhydration with intravenous fluid.

OBJECTIVE: To determine the number of National Football League (NFL) teams using pregame hyperhydration with intravenous fluid (IVF), the most common protocols for using the IVF, the complications from this routine, and the perceived efficacy of this treatment. DESIGN: Cross-sectional survey study. SETTING: National Football League. PARTICIPANTS: The head athletic trainer from all 32 NFL teams received and completed the survey. INTERVENTION: A survey designed to answer the aforementioned topics. MAIN OUTCOME MEASURES: Number of teams using IVF to hyperhydrate euvolemic players before NFL games. RESULTS: All teams (100%, 32 of 32) responded. Seventy-five percent (24 of 32) of NFL teams used pregame hyperhydration with IVF. On average, 5 to 7 players per team per game received IVF. Players received an average of 1.5 L of fluid, an average of 2.5 hours before the game. When the athletic trainers were asked to mark all the reasons why they use pregame hyperhydration with IVF, the most commonly cited reason was muscle cramps (23 of 24). However, player request was the number one answer (10 of 24) when the athletic trainers were asked to mark only the primary reason for giving IVF. Of the 27 head athletic trainers who had used pregame hyperhydration with IVF in the past, 13 (48%) reported complications. CONCLUSIONS: Pregame hyperhydration is a common practice in the NFL. Because pregame hyperhydration with IVF is often a player- driven routine and has potential complications, more scientific studies are needed to determine its true efficacy.

Delay to TKA in Patients Treated with a Multimodal Approach Using High Molecular Weight, Biologically Derived Hyaluronic Acid.

BACKGROUND: The primary objective of this study was to determine the effect of single versus multiple rounds of intra-articular hyaluronic acid (IA-HA) in delaying the need for total knee arthroplasty (TKA) in patients with knee OA, and if additional benefits were seen when used in conjunction with other multimodal treatment options. METHODS: This study was a retrospective claims analysis of a large commercial database containing more than 100 million patients with continuous coverage from October 1, 2010 through September 30, 2015. Time to TKA for patients who received one course of Euflexxa (IA-BioHA) were compared to patients who received two or more courses of IA-BioHA and patients who received no IA-HA. Assessment of multimodal treatment effects was done between the following groups: IA-BioHA injections alone, IA-BioHA and bracing, IA-BioHA and corticosteroid injection, and IA-BioHA with both corticosteroids and bracing. RESULTS: A total of 26,727 patients were included in the analysis of treatment courses, and 31,034 in the analysis of multimodal treatment combinations. The use of IA-BioHA demonstrated a delay of TKA that was prolonged with repeated courses of treatment (1.411 years, interquartile range [IQR]: 1.44). The greatest delay to TKA was observed for the patients who had received all three treatment options (1.5 years, IQR: 1.52) in the multimodal analysis. CONCLUSIONS: These results confirm that treatment of knee OA should consider the use of multimodal therapy instead of focusing on individual treatment options. Additionally, the use of repeated courses of IA-BioHA should be considered for prolonged benefit for patients with symptomatic knee OA.

The Most Cited Original Articles on Anterior Cruciate Ligament Injuries in the Past 20 Years.

Anterior cruciate ligament (ACL) injuries continue to be a major focus in sports medicine research. With so many changes to our understanding of ACL anatomy and with rapid advances in reconstruction techniques and rehabilitation protocols within the past 20 years, it is important to identify the landmark research that has laid the foundation for current ACL treatments. Using the Web of Science citation index, a search was carried out for the 30 most cited articles on ACL injury published in the last 20 years. The generated list was sorted from highest to lowest citation number. Clinical studies were subcategorized as therapeutic, prognostic, diagnostic, or economic/decision analysis and assigned a level of evidence. Basic science articles were designated anatomic, animal, biomechanical, or clinical. The number of citations per year (citation density) was calculated. The search yielded 6,345 articles. The total number of citations among the top 30 ranged from 188 to 611. Citation density ranged from 10.1 to 66.2. Nineteen articles were clinical, 8 were basic science, and 3 were video analyses. Clinical articles were most commonly therapeutic (18 of 19; 95%). Basic science articles were most commonly biomechanical (7 of 8; 88%). The most common level of evidence was Level II (10 of 19; 53%). More than half of the articles in the top 30 (16 of 30; 53%) were published in The American Journal of Sports Medicine. Many of these articles have played a large role in shaping current clinical practice regarding ACL injuries. We hope that by compiling this list we can draw attention to the continued need for studies of the highest level of evidence.