Detalhe da pesquisa
1.
Small-molecule antagonists of melanopsin-mediated phototransduction.
Nat Chem Biol
; 9(10): 630-5, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23974117
2.
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Bioorg Med Chem Lett
; 21(18): 5436-41, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782428
3.
N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.
Bioorg Med Chem Lett
; 21(18): 5573-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782430
4.
5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.
Bioorg Med Chem Lett
; 21(21): 6500-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924902
5.
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.
Nat Med
; 8(8): 825-30, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12118247
6.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
J Pharmacol Exp Ther
; 328(3): 900-11, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19098165
7.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit.
J Med Chem
; 50(16): 3870-82, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668921
8.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.
J Med Chem
; 50(16): 3883-90, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668922