Detalhe da pesquisa
1.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
2.
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.
Mol Cell
; 74(2): 320-329.e6, 2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30853402
3.
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Nat Methods
; 16(7): 595-602, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31249422
4.
GCN2: roles in tumour development and progression.
Biochem Soc Trans
; 50(2): 737-745, 2022 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311890
5.
Activation of GCN2 by the ribosomal P-stalk.
Proc Natl Acad Sci U S A
; 116(11): 4946-4954, 2019 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30804176
6.
Towards a model of GCN2 activation.
Biochem Soc Trans
; 47(5): 1481-1488, 2019 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647517
7.
Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.
Biochem J
; 474(11): 1867-1877, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28381646
8.
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling.
Biophys J
; 113(11): 2396-2405, 2017 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211993
9.
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Biochem J
; 473(2): 135-44, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26527737
10.
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).
Proc Natl Acad Sci U S A
; 109(38): 15259-64, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22949682
11.
Fundamentals of HDX-MS.
Essays Biochem
; 67(2): 301-314, 2023 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36251047
12.
A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response.
Front Mol Neurosci
; 16: 1112253, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825279
13.
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife
; 102021 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34519269
14.
Structural Mechanisms of PTEN Regulation.
Cold Spring Harb Perspect Med
; 10(3)2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31636093
15.
Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science
; 366(6462): 203-210, 2019 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31601764
16.
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.
Structure
; 26(3): 446-458.e8, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29478821
17.
An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.
Expert Opin Drug Discov
; 12(10): 981-994, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28770632
18.
Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.
Methods Mol Biol
; 1388: 215-30, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27033079
19.
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIß with Rab11.
Protein Sci
; 25(4): 826-39, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756197
20.
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.
Autophagy
; 12(11): 2129-2144, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27630019