Detalhe da pesquisa
1.
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
J Org Chem
; 89(10): 6639-6650, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651358
2.
Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.
Bioorg Med Chem
; 101: 117638, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38394996
3.
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 91: 129362, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37295614
4.
Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.
Bioorg Med Chem Lett
; 91: 129373, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315697
5.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem
; 85: 117273, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030194
6.
Tuberculosis in free-ranging and captive wild animals: Pathological and molecular diagnosis with histomorphological differentiation of granulomatous lesions.
Microb Pathog
; 172: 105752, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108989
7.
Mass spectrometric-based investigation of differentially protected azatryptophan derivatives using Orbitrap mass spectrometry: Differentiation of positional isomers under protonation and alkali-cationization conditions.
Rapid Commun Mass Spectrom
; 36(5): e9239, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34904316
8.
Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines.
Org Biomol Chem
; 20(48): 9746-9752, 2022 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36444969
9.
Intrinsic capacity of rural elderly in thar desert using world health organization integrated care for older persons screening tool: A pilot study.
Indian J Public Health
; 66(3): 337-340, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36149117
10.
Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3.
Glycobiology
; 31(10): 1390-1400, 2021 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228782
11.
Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.
J Org Chem
; 86(2): 1730-1747, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356273
12.
A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist.
J Org Chem
; 86(13): 8851-8861, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126006
13.
Synthesis and characterization of a series of N,N'-substituted urea derivatives by using electrospray ionization tandem mass spectrometry: Differentiation of positional isomers.
Rapid Commun Mass Spectrom
; 35(19): e9161, 2021 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240514
14.
Solvent-specific, DAST-mediated intramolecular Friedel-Crafts reaction: access to dibenzoxepine-fused spirooxindoles.
Org Biomol Chem
; 19(8): 1760-1768, 2021 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33538747
15.
Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.
J Am Chem Soc
; 142(6): 3094-3103, 2020 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31927959
16.
Synthesis of Differentially Protected Azatryptophan Analogs via Pd2(dba)3/XPhos Catalyzed Negishi Coupling of N-Ts Azaindole Halides with Zinc Derivative from Fmoc-Protected tert-Butyl (R)-2-Amino-3-iodopropanoate.
J Org Chem
; 85(17): 11519-11530, 2020 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786620
17.
Synthesis of 1-(tert-Butyl) 4-Methyl (1R,2S,4R)-2-Methylcyclohexane-1,4-dicarboxylate from Hagemann's tert-Butyl Ester for an Improved Synthesis of BMS-986251.
J Org Chem
; 85(16): 10988-10993, 2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32687358
18.
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Bioorg Med Chem Lett
; 30(1): 126782, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767265
19.
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.
Bioorg Med Chem Lett
; 30(17): 127392, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738966
20.
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem
; 28(13): 115541, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32389483