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Phys Med Biol ; 62(9): 3501-3509, 2017 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-28378708

RESUMO

Emergency room visits due to traumatic brain injury (TBI) is common, but classifying the severity of the injury remains an open challenge. Some subjective methods such as the Glasgow Coma Scale attempt to classify traumatic brain injuries, as well as some imaging based modalities such as computed tomography and magnetic resonance imaging. However, to date it is still difficult to detect and monitor mild to moderate injuries. In this report, we demonstrate that the magnetic particle imaging (MPI) modality can be applied to imaging TBI events with excellent contrast. MPI can monitor injected iron nanoparticles over long time scales without signal loss, allowing researchers and clinicians to monitor the change in blood pools as the wound heals.


Assuntos
Lesões Encefálicas Traumáticas/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Nanopartículas de Magnetita , Animais , Diagnóstico por Imagem/instrumentação , Feminino , Ratos , Ratos Endogâmicos F344
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