[Interaction of vasotonic bioeffectors in endothelial dysfunction pathogenesis due to arterial hypertension on aging].

One of the earliest impairments of target-organs due to arterial hypertension (AH) dysfunction is considered. The interrelation between AH and expressiveness of endothelial dysfunctions (ED) degree in the involutive changed vessels is defined. Features of mutual relation vasotonic bioeffectors--oxyde nitrogen (NO) and endothelin-1 (ET-1), interfaced to results of endothelial vasodilation are designated. The technique estimating epy degree of interaction between NO and ET-1 is offered. It is established, that against inertness vasodilation, developing under the combination of involutive and hypertensive damages, maintaining adequate blood flow in the vessel after the mechanical stress induced impact is provided at the expense of increase of speed of systolic and diastolic blood flow, improve the sensitivity of the endothelium to pressure of shift, change the synthesis and secretion of ET-1 and NO.

[Interrelation of endothelial and myocardial dysfunction in persons of elderly age with arterial hypertension].

For the purpose of estimation of peculiarities of interrelation between endothelial dysfunction (ED) and myocardial dysfunction (MD) in elderly persons due to arterial hypertension (AH) 66 patients of elderly age with AH of II stage and 26 persons of similar age without cardiovascular diseases were examined. It is established, that development AH is accompanied by formation of a concentric hypertrophy and concentric remodelling of myocardium, diastolic and systolodiastolic myocardial dysfunction, its expressiveness is interfaced to severity of endothelial dysfunction. Progressing of ED is accompanied by infringements of lipids' metabolism, increasing of their peroxidation activity and decreasing in efficiency of anti-oxidation protection.