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1.
Phys Rev Lett ; 124(18): 185001, 2020 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-32441948

RESUMO

Radiation-hydrodynamic simulations of directly driven fusion experiments at the Omega Laser Facility predict absorption accurately when targets are driven at low overlapped laser intensity. Discrepancies appear at increased intensity, however, with higher-than-expected laser absorption on target. Strong correlations with signatures of the two-plasmon decay (TPD) instability-including half-harmonic and hard-x-ray emission-indicate that TPD is responsible for this anomalous absorption. Scattered light data suggest that up to ≈30% of the laser power reaching quarter-critical density can be absorbed locally when the TPD threshold is exceeded. A scaling of absorption versus TPD threshold parameter was empirically determined and validated using the laser-plasma simulation environment code.

2.
Phys Rev Lett ; 123(23): 235001, 2019 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-31868457

RESUMO

The material release on the side opposite to the laser drive of a CH shell was probed at conditions relevant to inertial confinement fusion. The release was found to expand further with a longer scale length than that predicted by radiation-hydrodynamic simulations. The simulations show that a relaxation of the back side of the shell consistent with measurements explains the experimentally observed reduction in inertial confinement fusion implosion performance-specifically, reduced areal density at peak compression.

3.
Phys Rev Lett ; 113(10): 105001, 2014 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-25238364

RESUMO

The linear stability of multiple coherent laser beams with respect to two-plasmon-decay instability in an inhomogeneous plasma in three dimensions has been determined. Cooperation between beams leads to absolute instability of long-wavelength decays, while shorter-wavelength shared waves are shown to saturate convectively. The multibeam, in its absolutely unstable form, has the lowest threshold for most cases considered. Nonlinear calculations using a three-dimensional extended Zakharov model show that Langmuir turbulence created by the absolute instability modifies the convective saturation of the shorter-wavelength modes, which are seen to dominate at late times.

4.
Phys Rev Lett ; 108(17): 175002, 2012 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-22680873

RESUMO

A new hot-electron generation mechanism in two-plasmon-decay instabilities is described based on a series of 2D, long-term (~10 ps) particle-in-cell and fluid simulations under parameters relevant to inertial confinement fusion. The simulations show that significant laser absorption and hot-electron generation occur in the nonlinear stage. The hot electrons are stage accelerated from the low-density region to the high-density region. New modes with small phase velocities develop in the low-density region in the nonlinear stage and form the first stage for electron acceleration. Electron-ion collisions are shown to significantly reduce the efficiency of this acceleration mechanism.

5.
Phys Rev Lett ; 109(15): 155007, 2012 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-23102322

RESUMO

The energy in hot electrons produced by the two plasmon decay instability, in planar targets, is measured to be the same when driven by one or two laser beams and significantly reduced with four for a constant overlapped intensity on the OMEGA EP. This is caused by multiple beams sharing the same common electron-plasma wave. A model, consistent with the experimental results, predicts that multiple laser beams can only drive a resonant common two plasmon decay electron-plasma wave in the region of wave numbers bisecting the beams. In this region, the gain is proportional to the overlapped laser beam intensity.

6.
Phys Rev E ; 104(4-2): 045207, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34781542

RESUMO

A combined approach to study cold rarefied matter is introduced that includes a semianalytical method based on the free-energy minimization and ab initio calculations based on the finite-temperature density-functional theory. The approach is used to calculate the ionization state of hydrocarbon (CH) under the shock-release conditions in inertial confinement fusion. The dielectric constant of CH is calculated using the Kubo-Greenwood formulation and contribution from atomic polarizabilities is found to be as important as the free-electron contribution. Using the ionization state and dielectric constant, the electron density profile in the rarefaction wave of the shock-release plasma is obtained.

7.
Phys Rev E ; 102(2-1): 023205, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32942510

RESUMO

The success of direct laser-driven inertial confinement fusion (ICF) relies critically on the efficient coupling of laser light to plasma. At ignition scale, the absolute stimulated Raman scattering (SRS) instability can severely inhibit this coupling by redirecting and strongly depleting laser light. This article describes a new dynamic saturation regime of the absolute SRS instability near one-quarter of the critical density. The saturation occurs when spatiotemporal ion-acoustic fluctuations in the plasma density detune the instability resonance. The dynamic saturation mitigates the strong depletion of laser light and enhances its transmission through the instability region, explaining the coupling of laser light to ICF targets at higher plasma densities.

8.
Phys Rev Lett ; 103(17): 175002, 2009 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-19905766

RESUMO

Particle-in-cell (PIC) and fluid simulations of two-plasmon decay (TPD) instability under conditions relevant to inertial confinement fusion show the importance of convective modes. Growing at the lower density region, the convective modes can cause pump depletion and are energetically dominant in the nonlinear stage. The PIC simulations show that TPD saturates due to ion density fluctuations, which can turn off TPD by raising the instability threshold through mode coupling.

9.
Phys Rev E Stat Nonlin Soft Matter Phys ; 79(6 Pt 2): 066409, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19658614

RESUMO

Expressions for the yield of electron-positron pairs, their energy spectra, and production rates have been obtained in the interaction of multi-kJ pulses of high-intensity laser light interacting with solid targets. The Bethe-Heitler conversion of hard x-ray bremsstrahlung [D. A. Gryaznykh, Y. Z. Kandiev, and V. A. Lykov, JETP Lett. 67, 257 (1998); K. Nakashima and H. Takabe, Phys. Plasmas 9, 1505 (2002)] is shown to dominate over direct production (trident process) [E. P. Liang, S. C. Wilks, and M. Tabak, Phys. Rev. Lett. 81, 4887 (1998)]. The yields and production rates have been optimized as a function of incident laser intensity by the choice of target material and dimensions, indicating that up to 5 x 10 (11) pairs can be produced on the OMEGA EP laser system [L. J. Waxer, Opt. Photonics News 16, 30 (2005)]. The corresponding production rates are high enough to make possible the creation of a pair plasma.

10.
Phys Rev E ; 100(4-1): 041201, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31771012

RESUMO

The nonlinear regime of laser-plasma interactions including both two-plasmon decay (TPD) and stimulated Raman scattering (SRS) instabilities has been studied in three-dimensional (3D) particle-in-cell simulations with parameters relevant to the inertial confinement fusion (ICF) experiments. SRS and TPD develop in the same region in plasmas, and the generation of fast electrons can be described accurately with only the full model including both SRS and TPD. The growth of instabilities in the linear stage is found to be in good agreement with analytical theories. In the saturation stage the low-frequency density perturbations driven by the daughter waves of the SRS side scattering can saturate the TPD and consequently inhibit the fast-electron generation. The fast-electron flux in 3D modeling is up to an order of magnitude smaller than previously reported in 2D TPD simulations, bringing it close to the results of ICF experiments.

11.
Rev Sci Instrum ; 89(3): 033504, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29604737

RESUMO

An experimental platform for the studying of high-intensity laser plasma interactions in strong magnetic fields has been developed based on the 1 MA Zebra pulsed power generator coupled with the 50-TW Leopard laser. The Zebra generator produces 100-300 T longitudinal and transverse magnetic fields with different types of loads. The Leopard laser creates plasma at an intensity of 1019 W/cm2 in the magnetic field of coil loads. Focusing and targeting systems are integrated in the vacuum chamber of the pulsed power generator and protected from the plasma debris and strong mechanical shock. The first experiments with plasma at laser intensity >2 × 1018 W/cm2 demonstrated collimation of the laser produced plasma in the axial magnetic field strength >100 T.

12.
Mol Biol Cell ; 7(12): 1857-64, 1996 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8970150

RESUMO

With the use of the patch clamp technique, the role of cytoskeleton in the regulation of ion channels in plasma membrane of leukemic K562 cells was examined. Single-channel measurements have indicated that disruption of actin filaments with cytochalasin D (CD) resulted in a considerable increase of the activity of non-voltage-gated sodium-permeable channels of 12 pS unitary conductance. Background activity of these channels was low; open probability (po) did not exceed 0.01-0.02. After CD, po grew at least 10-20 times. Cell-attached and whole-cell recordings showed that activation of sodium channels was elicited within 1-3 min after the addition of 10-20 micrograms/ml CD to the bath extracellular solution or in the presence of 5 micrograms/ml CD in the intracellular pipette solution. Preincubation of K562 cells with CD during 1 h also increased drastically the activity of 12 pS sodium channels. Whole-cell measurements confirmed that CD-activated channels were permeable to monovalent cations (preferentially to Na+ and Li+), but not to bivalent cations (Ca2+, Ba2+). Colchicine (1 microM), which affect microtubules, did not alter background channel activity. Our data indicate that actin filaments organization plays an important role in the regulation of sodium-permeable channels which may participate in providing passive Na+ influx in red blood cells.


Assuntos
Citoesqueleto de Actina/efeitos dos fármacos , Actinas , Citocalasina D/farmacologia , Canais de Sódio/fisiologia , Permeabilidade da Membrana Celular/efeitos dos fármacos , Eletrofisiologia , Humanos , Leucemia Mieloide/patologia , Técnicas de Patch-Clamp , Células Tumorais Cultivadas
13.
FEBS Lett ; 412(1): 94-6, 1997 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-9257697

RESUMO

With the use of the patch-clamp technique, physiological mechanisms of Na+ channel regulation involving submembranous actin rearrangements were examined in human myeloid leukemia K562 cells. We found that the actin-severing protein gelsolin applied to cytoplasmic surface of membrane fragments at a high level of [Ca2+]i (1 microM) increased drastically the activity of Na-selective channels of 12 pS unitary conductance. In the experiments on intact cells, the elevation of [Ca2+]i using the ionophore 4Br-A23187 also resulted in Na+ channel activation. Addition of actin to the cytoplasmic surface of membrane patches reduced this activity to background level, likely due to actin polymerization. Our data imply that Ca-dependent modulations of the actin cytoskeleton may represent one of the general mechanisms of channel regulation and cell signalling.


Assuntos
Actinas/fisiologia , Cálcio/farmacologia , Citoesqueleto/efeitos dos fármacos , Citoesqueleto/fisiologia , Leucemia Mieloide Aguda/fisiopatologia , Canais de Sódio/fisiologia , Actinas/química , Actinas/metabolismo , Calcimicina/farmacologia , Citoesqueleto/química , Condutividade Elétrica , Gelsolina/metabolismo , Humanos , Técnicas de Patch-Clamp , Células Tumorais Cultivadas
14.
Gen Physiol Biophys ; 16(2): 163-73, 1997 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9437257

RESUMO

Patch clamp method was used to search for, and characterize ion channel activity which may participate in cation influx in human myeloid K562 cells. In cell-attached, outside-out and whole-cell experiments two types of voltage-insensitive Na-permeable channels were identified with different selectivities for monovalent cations, referred to as channels of high (HS) and low (LS) selectivity. The unitary conductance was similar for both channel types being 12 pS (145 mmol/l Na, 23 degrees C). The relative permeability PNa/PK estimated from the extrapolated reversal potential values were 10 and 3 for HS and LS channels, respectively. Both HS and LS channels were found to be impermeable to bivalent cations (Ca2+ or Ba2+). The activity of HS and LS channels displayed a tendency to increase with depolarization. Both channel types were not blocked by tetrodotoxin and were insensitive to amiloride in the concentration range of up to 100 mumol/l. At higher concentrations (0.1-2 mmol/l), amiloride reversibly inhibited HS channels only. The results obtained lead us to conclude that, under physiological conditions, both types of Na-permeable channels may provide sodium influx in leukemic cells. Our data imply the existence of a novel family of Na channels in blood cells.


Assuntos
Permeabilidade da Membrana Celular , Membrana Celular/fisiologia , Ativação do Canal Iônico , Leucemia Mieloide/metabolismo , Canais de Sódio/fisiologia , Amilorida/farmacologia , Bário/metabolismo , Cálcio/metabolismo , Diuréticos/farmacologia , Humanos , Leucemia Mieloide/patologia , Técnicas de Patch-Clamp , Tetrodotoxina/farmacologia , Células Tumorais Cultivadas
15.
Phys Rev Lett ; 90(23): 235002, 2003 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-12857266

RESUMO

Experiments with multiple laser beams have been carried out in both spherical and planar geometry to study two-plasmon-decay instability, the predominant source of suprathermal electrons in direct-drive inertial confinement fusion experiments. These electrons are observed using the hard x rays generated through electron-target interactions. The experiments show for the first time that the total overlapped intensity governs the scaling of the suprathermal-electron generation regardless of the number of overlapped beams, in contrast to conventional theories that are based on the single-beam approximation.

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