Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice.

Nagy, Zoltan; Mori, Jun; Ivanova, Vanesa-Sindi; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 135(18): 1574-1587, 2020 04 30.

Artigo em Inglês | MEDLINE | ID: mdl-32016283

2.

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions.

Bellio, Marie; Garcia, Cédric; Edouard, Thomas; Voisin, Sophie; Neel, Benjamin G; Cabou, Cendrine; Valet, Philippe; Mori, Jun; Mazharian, Alexandra; Senis, Yotis A; Yart, Armelle; Payrastre, Bernard; Severin, Sonia.

Blood ; 134(25): 2304-2317, 2019 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-31562133

3.

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.

Nagy, Zoltan; Vögtle, Timo; Geer, Mitchell J; Mori, Jun; Heising, Silke; Di Nunzio, Giada; Gareus, Ralph; Tarakhovsky, Alexander; Weiss, Arthur; Neel, Benjamin G; Desanti, Guillaume E; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 133(4): 331-343, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30429161

4.

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

Geer, Mitchell J; van Geffen, Johanna P; Gopalasingam, Piraveen; Vögtle, Timo; Smith, Christopher W; Heising, Silke; Kuijpers, Marijke J E; Tullemans, Bibian M E; Jarvis, Gavin E; Eble, Johannes A; Jeeves, Mark; Overduin, Michael; Heemskerk, Johan W M; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 132(13): 1413-1425, 2018 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-29891536

5.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori, Jun; Nagy, Zoltan; Di Nunzio, Giada; Smith, Christopher W; Geer, Mitchell J; Al Ghaithi, Rashid; van Geffen, Johanna P; Heising, Silke; Boothman, Luke; Tullemans, Bibian M E; Correia, Joao N; Tee, Louise; Kuijpers, Marijke J E; Harrison, Paul; Heemskerk, Johan W M; Jarvis, Gavin E; Tarakhovsky, Alexander; Weiss, Arthur; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 131(10): 1122-1144, 2018 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-29301754

6.

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann, Inga; Geer, Mitchell J; Vögtle, Timo; Crispin, Andrew; Campagna, Dean R; Barr, Alastair; Calicchio, Monica L; Heising, Silke; van Geffen, Johanna P; Kuijpers, Marijke J E; Heemskerk, Johan W M; Eble, Johannes A; Schmitz-Abe, Klaus; Obeng, Esther A; Douglas, Michael; Freson, Kathleen; Pondarré, Corinne; Favier, Rémi; Jarvis, Gavin E; Markianos, Kyriacos; Turro, Ernest; Ouwehand, Willem H; Mazharian, Alexandra; Fleming, Mark D; Senis, Yotis A.

Blood ; 132(13): 1399-1412, 2018 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-29898956

7.

Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.

Smith, Christopher W; Thomas, Steven G; Raslan, Zaher; Patel, Pushpa; Byrne, Maxwell; Lordkipanidzé, Marie; Bem, Danai; Meyaard, Linde; Senis, Yotis A; Watson, Steve P; Mazharian, Alexandra.

Arterioscler Thromb Vasc Biol ; 37(5): 823-835, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28336561

8.

Proplatelets slip slidin' away.

Mazharian, Alexandra; Senis, Yotis A.

Blood ; 125(5): 747-8, 2015 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-25634614

9.

Src family kinases: at the forefront of platelet activation.

Senis, Yotis A; Mazharian, Alexandra; Mori, Jun.

Blood ; 124(13): 2013-24, 2014 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-25115887

10.

Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide.

Cardo, Lucia; Thomas, Steve G; Mazharian, Alexandra; Pikramenou, Zoe; Rappoport, Joshua Z; Hannon, Michael J; Watson, Stephen P.

Chembiochem ; 16(11): 1680-8, 2015 Jul 27.

Artigo em Inglês | MEDLINE | ID: mdl-26062886

11.

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Mazharian, Alexandra; Mori, Jun; Wang, Ying-Jie; Heising, Silke; Neel, Benjamin G; Watson, Steve P; Senis, Yotis A.

Blood ; 121(20): 4205-20, 2013 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-23509158

12.

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).

Zhang, Lin; Urtz, Nicole; Gaertner, Florian; Legate, Kyle R; Petzold, Tobias; Lorenz, Michael; Mazharian, Alexandra; Watson, Steve P; Massberg, Steffen.

Blood ; 122(5): 791-802, 2013 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-23775711

13.

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia.

Hobbs, Catherine M; Manning, Harriet; Bennett, Cavan; Vasquez, Louella; Severin, Sonia; Brain, Lauren; Mazharian, Alexandra; Guerrero, Jose A; Li, Juan; Soranzo, Nicole; Green, Anthony R; Watson, Steve P; Ghevaert, Cedric.

Blood ; 122(23): 3787-97, 2013 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-24085768

14.

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics.

Mazharian, Alexandra; Bertin, Ophélie; Sarkar, Amrita; Augros, Johanna; Bornert, Alicia; Loubière, Cécile; Jönsson, Friederike; Warwicker, Juli; Abbott, W Mark; Dushek, Omer; Vayne, Caroline; Rauova, Lubica; Fütterer, Klaus; Rollin, Jérôme; Poncz, Mortimer; Senis, Yotis A.

bioRxiv ; 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38798354

15.

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.

Mazharian, Alexandra; Ghevaert, Cedric; Zhang, Lin; Massberg, Steffen; Watson, Steve P.

Blood ; 117(19): 5198-206, 2011 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-21385851

16.

A thrombus is formed by a gradient of platelet activation and procoagulant endothelium.

Carminita, Estelle; Tourn, Julie; Crescence, Lydie; Brouilly, Nicolas; Merrill-Skoloff, Glenn; Mazharian, Alexandra; Dubois, Christophe; Panicot-Dubois, Laurence.

Res Pract Thromb Haemost ; 7(7): 102209, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-38077809

17.

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B-deficient mice.

Mazharian, Alexandra; Maître, Blandine; Bornert, Alicia; Hennequin, Desline; Lourenco-Rodrigues, Marc; Geer, Mitchell J; Smith, Christopher W; Heising, Silke; Walter, Michaela; Montel, Florian; Walker, Lucy S K; de la Salle, Henri; Watson, Steve P; Gachet, Christian; Senis, Yotis A.

Blood Adv ; 7(1): 46-59, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36269841

18.

Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.

Mazharian, Alexandra; Thomas, Steve G; Dhanjal, Tarvinder S; Buckley, Christopher D; Watson, Steve P.

Blood ; 116(5): 793-800, 2010 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-20457868

19.

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

Senis, Yotis A; Tomlinson, Michael G; Ellison, Stuart; Mazharian, Alexandra; Lim, Jenson; Zhao, Yan; Kornerup, Kristin N; Auger, Jocelyn M; Thomas, Steve G; Dhanjal, Tarvinder; Kalia, Neena; Zhu, Jing W; Weiss, Arthur; Watson, Steve P.

Blood ; 113(20): 4942-54, 2009 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-19246339

20.

Severity of Megakaryocyte-Driven Osteosclerosis in Mpig6b-Deficient Mice Is Sex-Linked.

Stavnichuk, Mariya; Tauer, Josephine T; Nagy, Zoltan; Mazharian, Alexandra; Welman, Mélanie; Lordkipanidzé, Marie; Senis, Yotis A; Komarova, Svetlana V.

J Bone Miner Res ; 36(4): 803-813, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33434328

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