Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Not all autophagy membranes are created equal.

McEwan, David G; Dikic, Ivan.

Cell ; 141(4): 564-6, 2010 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-20478247

2.

ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.

Long, Jaclyn S; Kania, Elzbieta; McEwan, David G; Barthet, Valentin J A; Brucoli, Martina; Ladds, Marcus J G W; Nössing, Christoph; Ryan, Kevin M.

Proc Natl Acad Sci U S A ; 119(28): e2113465119, 2022 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-35867735

3.

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.

McEwan, David G; Popovic, Doris; Gubas, Andrea; Terawaki, Seigo; Suzuki, Hironori; Stadel, Daniela; Coxon, Fraser P; Miranda de Stegmann, Diana; Bhogaraju, Sagar; Maddi, Karthik; Kirchof, Anja; Gatti, Evelina; Helfrich, Miep H; Wakatsuki, Soichi; Behrends, Christian; Pierre, Philippe; Dikic, Ivan.

Mol Cell ; 57(1): 39-54, 2015 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-25498145

4.

A conserved ATG2-GABARAP family interaction is critical for phagophore formation.

Bozic, Mihaela; van den Bekerom, Luuk; Milne, Beth A; Goodman, Nicola; Roberston, Lisa; Prescott, Alan R; Macartney, Thomas J; Dawe, Nina; McEwan, David G.

EMBO Rep ; 21(3): e48412, 2020 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-32009292

5.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov, Vladimir V; Stolz, Alexandra; Ravichandran, Arvind C; Rios-Szwed, Diana O; Suzuki, Hironori; Kniss, Andreas; Löhr, Frank; Wakatsuki, Soichi; Dötsch, Volker; Dikic, Ivan; Dobson, Renwick Cj; McEwan, David G.

EMBO Rep ; 18(8): 1382-1396, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28655748

6.

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.

Habisov, Sabrina; Huber, Jessica; Ichimura, Yoshinobu; Akutsu, Masato; Rogova, Natalia; Loehr, Frank; McEwan, David G; Johansen, Terje; Dikic, Ivan; Doetsch, Volker; Komatsu, Masaaki; Rogov, Vladimir V; Kirkin, Vladimir.

J Biol Chem ; 291(17): 9025-41, 2016 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-26929408

7.

A role for ubiquitin in selective autophagy.

Kirkin, Vladimir; McEwan, David G; Novak, Ivana; Dikic, Ivan.

Mol Cell ; 34(3): 259-69, 2009 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-19450525

8.

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Kirkin, Vladimir; Lamark, Trond; Sou, Yu-Shin; Bjørkøy, Geir; Nunn, Jennifer L; Bruun, Jack-Ansgar; Shvets, Elena; McEwan, David G; Clausen, Terje H; Wild, Philipp; Bilusic, Ivana; Theurillat, Jean-Philippe; Øvervatn, Aud; Ishii, Tetsuro; Elazar, Zvulun; Komatsu, Masaaki; Dikic, Ivan; Johansen, Terje.

Mol Cell ; 33(4): 505-16, 2009 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-19250911

9.

The LC3 interactome at a glance.

Wild, Philipp; McEwan, David G; Dikic, Ivan.

J Cell Sci ; 127(Pt 1): 3-9, 2014 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-24345374

10.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov, Vladimir V; Stolz, Alexandra; Ravichandran, Arvind C; Rios-Szwed, Diana O; Suzuki, Hironori; Kniss, Andreas; Löhr, Frank; Wakatsuki, Soichi; Dötsch, Volker; Dikic, Ivan; Dobson, Renwick Cj; McEwan, David G.

EMBO Rep ; 19(12)2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30518659

11.

Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.

Rogov, Vladimir V; Suzuki, Hironori; Fiskin, Evgenij; Wild, Philipp; Kniss, Andreas; Rozenknop, Alexis; Kato, Ryuichi; Kawasaki, Masato; McEwan, David G; Löhr, Frank; Güntert, Peter; Dikic, Ivan; Wakatsuki, Soichi; Dötsch, Volker.

Biochem J ; 454(3): 459-66, 2013 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-23805866

12.

Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy.

Cross, Jake; Durgan, Joanne; McEwan, David G; Tayler, Matthew; Ryan, Kevin M; Florey, Oliver.

J Cell Biol ; 222(12)2023 12 04.

Artigo em Inglês | MEDLINE | ID: mdl-37796195

13.

LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner.

Kania, Elzbieta; Long, Jaclyn S; McEwan, David G; Welkenhuyzen, Kirsten; La Rovere, Rita; Luyten, Tomas; Halpin, John; Lobbestael, Evy; Baekelandt, Veerle; Bultynck, Geert; Ryan, Kevin M; Parys, Jan B.

Cell Death Dis ; 14(7): 436, 2023 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-37454104

14.

Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression.

Karantanou, Christina; Minciacchi, Valentina R; Kumar, Rahul; Zanetti, Costanza; Bravo, Jimena; Pereira, Raquel S; Tascher, Georg; Tertel, Tobias; Covarrubias-Pinto, Adriana; Bankov, Katrin; Pfeffermann, Lisa-Marie; Bonig, Halvard; Divieti-Pajevic, Paola; McEwan, David G; Giebel, Bernd; Münch, Christian; Dikic, Ivan; Krause, Daniela S.

Blood Adv ; 7(7): 1190-1203, 2023 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-36044386

15.

Atg8 family proteins, LIR/AIM motifs and other interaction modes.

Rogov, Vladimir V; Nezis, Ioannis P; Tsapras, Panagiotis; Zhang, Hong; Dagdas, Yasin; Noda, Nobuo N; Nakatogawa, Hitoshi; Wirth, Martina; Mouilleron, Stephane; McEwan, David G; Behrends, Christian; Deretic, Vojo; Elazar, Zvulun; Tooze, Sharon A; Dikic, Ivan; Lamark, Trond; Johansen, Terje.

Autophagy Rep ; 2(1)2023 Dec 31.

Artigo em Inglês | MEDLINE | ID: mdl-38214012

16.

Nix is a selective autophagy receptor for mitochondrial clearance.

Novak, Ivana; Kirkin, Vladimir; McEwan, David G; Zhang, Ji; Wild, Philipp; Rozenknop, Alexis; Rogov, Vladimir; Löhr, Frank; Popovic, Doris; Occhipinti, Angelo; Reichert, Andreas S; Terzic, Janos; Dötsch, Volker; Ney, Paul A; Dikic, Ivan.

EMBO Rep ; 11(1): 45-51, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-20010802

17.

ATG2 and VPS13 proteins: molecular highways transporting lipids to drive membrane expansion and organelle communication.

McEwan, David G; Ryan, Kevin M.

FEBS J ; 289(22): 7113-7127, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-34783437

18.

DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions.

Barthet, Valentin J A; Mrschtik, Michaela; Kania, Elzbieta; McEwan, David G; Croft, Dan; O'Prey, James; Long, Jaclyn S; Ryan, Kevin M.

FEBS J ; 289(13): 3752-3769, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35060334

19.

Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis.

Wu, Yixing; Bai, Ying; McEwan, David G; Bentley, Liz; Aravani, Dimitra; Cox, Roger D.

Biol Open ; 10(12)2021 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-34779483

20.

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.

Valecka, Jan; Camosseto, Voahirana; McEwan, David G; Terawaki, Seigo; Liu, Zhuangzhuang; Strock, Eva; Almeida, Catarina R; Su, Bing; Dikic, Ivan; Liang, Yinming; Gatti, Evelina; Pierre, Philippe.

R Soc Open Sci ; 8(7): 202333, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-34295519

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Not all autophagy membranes are created equal.

ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.

A conserved ATG2-GABARAP family interaction is critical for phagophore formation.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.

A role for ubiquitin in selective autophagy.

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

The LC3 interactome at a glance.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.

Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy.

LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner.

Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression.

Atg8 family proteins, LIR/AIM motifs and other interaction modes.

Nix is a selective autophagy receptor for mitochondrial clearance.

ATG2 and VPS13 proteins: molecular highways transporting lipids to drive membrane expansion and organelle communication.

DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions.

Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis.

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.