Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy.

Seth, Ryan; McKinnon, Thomas A J; Zhang, X Frank.

Am J Physiol Heart Circ Physiol ; 322(1): H87-H93, 2022 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-34890277

2.

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance.

Ward, Soracha E; O'Sullivan, Jamie M; Moran, Alan B; Spencer, Daniel I R; Gardner, Richard A; Sharma, Jyotika; Fazavana, Judicael; Monopoli, Marco; McKinnon, Thomas A J; Chion, Alain; Haberichter, Sandra; O'Donnell, James S.

Haematologica ; 107(3): 668-679, 2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33763999

3.

Taking AIM.

McKinnon, Thomas A J.

Blood ; 143(19): 1887-1888, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38722656

4.

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing.

Ishihara, Jun; Ishihara, Ako; Starke, Richard D; Peghaire, Claire R; Smith, Koval E; McKinnon, Thomas A J; Tabata, Yoji; Sasaki, Koichi; White, Michael J V; Fukunaga, Kazuto; Laffan, Mike A; Lutolf, Matthias P; Randi, Anna M; Hubbell, Jeffrey A.

Blood ; 133(24): 2559-2569, 2019 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-30975637

5.

2B or not 2B: art thou autoinhibitory?

McKinnon, Thomas A J.

Blood ; 141(10): 1102-1103, 2023 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-36893008

6.

Getting under the skin: a new route for factor VIII?

McKinnon, Thomas A J.

Blood ; 137(8): 1007-1008, 2021 02 25.

Artigo em Inglês | MEDLINE | ID: mdl-33630048

7.

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

Chion, Alain; O'Sullivan, Jamie M; Drakeford, Clive; Bergsson, Gudmundur; Dalton, Niall; Aguila, Sonia; Ward, Soracha; Fallon, Padraic G; Brophy, Teresa M; Preston, Roger J S; Brady, Lauren; Sheils, Orla; Laffan, Michael; McKinnon, Thomas A J; O'Donnell, James S.

Blood ; 128(15): 1959-1968, 2016 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-27554083

8.

Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells.

Starke, Richard D; Paschalaki, Koralia E; Dyer, Clare E F; Harrison-Lavoie, Kimberly J; Cutler, Jacqueline A; McKinnon, Thomas A J; Millar, Carolyn M; Cutler, Daniel F; Laffan, Mike A; Randi, Anna M.

Blood ; 121(14): 2773-84, 2013 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-23355534

9.

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions.

Nowak, Agata A; Canis, Kevin; Riddell, Anne; Laffan, Michael A; McKinnon, Thomas A J.

Blood ; 120(1): 214-22, 2012 Jul 05.

Artigo em Inglês | MEDLINE | ID: mdl-22517896

10.

Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S.

Ahnström, Josefin; Andersson, Helena M; Hockey, Verity; Meng, Yiran; McKinnon, Thomas A J; Hamuro, Tsutomu; Crawley, James T B; Lane, David A.

Blood ; 120(25): 5059-62, 2012 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-23074276

11.

The proteasome inhibitor carfilzomib exerts anti-inflammatory and antithrombotic effects on the endothelium.

Hjazi, Ahmed; Maroto, Celia Gonzalez; Rodriguez-Gutierrez, Maria Elena; Appiah, Michael; Ignat, Ana; Mobayen, Golzar; Page, Theresa; McKinnon, Thomas A J.

J Thromb Haemost ; 2024 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-38608731

12.

Endothelial von Willebrand factor regulates angiogenesis.

Starke, Richard D; Ferraro, Francesco; Paschalaki, Koralia E; Dryden, Nicola H; McKinnon, Thomas A J; Sutton, Rachel E; Payne, Elspeth M; Haskard, Dorian O; Hughes, Alun D; Cutler, Daniel F; Laffan, Mike A; Randi, Anna M.

Blood ; 117(3): 1071-80, 2011 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-21048155

13.

Mapping the N-glycome of human von Willebrand factor.

Canis, Kevin; McKinnon, Thomas A J; Nowak, Agata; Haslam, Stuart M; Panico, Maria; Morris, Howard R; Laffan, Mike A; Dell, Anne.

Biochem J ; 447(2): 217-28, 2012 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-22849435

14.

von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.

Mobayen, Golzar; Smith, Koval; Ediriwickrema, Kushani; Starke, Richard D; Solomonidis, Emmanouil Georgios; Laffan, Michael A; Randi, Anna M; McKinnon, Thomas A J.

J Thromb Haemost ; 21(7): 1802-1812, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37011710

15.

Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor.

McKinnon, Thomas A J; Goode, Elizabeth C; Birdsey, Graeme M; Nowak, Agata A; Chan, Alain C K; Lane, David A; Laffan, Michael A.

Blood ; 116(4): 640-8, 2010 Jul 29.

Artigo em Inglês | MEDLINE | ID: mdl-20418283

16.

Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13.

McGrath, Rachel T; McKinnon, Thomas A J; Byrne, Barry; O'Kennedy, Richard; Terraube, Virginie; McRae, Emily; Preston, Roger J S; Laffan, Mike A; O'Donnell, James S.

Blood ; 115(13): 2666-73, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-19965639

17.

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

Zanardelli, Sara; Chion, Alain C K; Groot, Evelyn; Lenting, Peter J; McKinnon, Thomas A J; Laffan, Mike A; Tseng, Michelle; Lane, David A.

Blood ; 114(13): 2819-28, 2009 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-19587373

18.

Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor.

Riddell, Anne F; Gomez, Keith; Millar, Carolyn M; Mellars, Gillian; Gill, Saher; Brown, Simon A; Sutherland, Megan; Laffan, Mike A; McKinnon, Thomas A J.

Blood ; 114(16): 3489-96, 2009 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-19687512

19.

Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress.

O'Brien, Harrison E R; Zhang, X Frank; Sanz-Hernandez, Maximo; Chion, Alain; Shapiro, Susan; Mobayen, Golzar; Xu, Yan; De Simone, Alfonso; Laffan, Michael A; McKinnon, Thomas A J.

J Thromb Haemost ; 19(2): 358-369, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33075181

20.

N-linked glycosylation of VWF modulates its interaction with ADAMTS13.

McKinnon, Thomas A J; Chion, Alain C K; Millington, Alexander J; Lane, David A; Laffan, Mike A.

Blood ; 111(6): 3042-9, 2008 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-17975018

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Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy.

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance.

Taking AIM.

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing.

2B or not 2B: art thou autoinhibitory?

Getting under the skin: a new route for factor VIII?

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells.

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions.

Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S.

The proteasome inhibitor carfilzomib exerts anti-inflammatory and antithrombotic effects on the endothelium.

Endothelial von Willebrand factor regulates angiogenesis.

Mapping the N-glycome of human von Willebrand factor.

von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.

Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor.

Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13.

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor.

Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress.

N-linked glycosylation of VWF modulates its interaction with ADAMTS13.