Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Prehospital Tranexamic Acid for Severe Trauma.

Gruen, Russell L; Mitra, Biswadev; Bernard, Stephen A; McArthur, Colin J; Burns, Brian; Gantner, Dashiell C; Maegele, Marc; Cameron, Peter A; Dicker, Bridget; Forbes, Andrew B; Hurford, Sally; Martin, Catherine A; Mazur, Stefan M; Medcalf, Robert L; Murray, Lynnette J; Myles, Paul S; Ng, Sze J; Pitt, Veronica; Rashford, Stephen; Reade, Michael C; Swain, Andrew H; Trapani, Tony; Young, Paul J.

N Engl J Med ; 389(2): 127-136, 2023 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-37314244

2.

N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.

Ameen, S Sadia; Griem-Krey, Nane; Dufour, Antoine; Hossain, M Iqbal; Hoque, Ashfaqul; Sturgeon, Sharelle; Nandurkar, Harshal; Draxler, Dominik F; Medcalf, Robert L; Kamaruddin, Mohd Aizuddin; Lucet, Isabelle S; Leeming, Michael G; Liu, Dazhi; Dhillon, Amardeep; Lim, Jet Phey; Basheer, Faiza; Zhu, Hong-Jian; Bokhari, Laita; Roulston, Carli L; Paradkar, Prasad N; Kleifeld, Oded; Clarkson, Andrew N; Wellendorph, Petrine; Ciccotosto, Giuseppe D; Williamson, Nicholas A; Ang, Ching-Seng; Cheng, Heung-Chin.

Mol Cell Proteomics ; 22(5): 100543, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37030595

3.

Entry of cannabidiol into the fetal, postnatal and adult rat brain.

Fitzpatrick, Georgia; Huang, Yifan; Qiu, Fiona; Habgood, Mark D; Medcalf, Robert L; Ho, Heidi; Dziegielewska, Katarzyna M; Saunders, Norman R.

Cell Tissue Res ; 396(2): 177-195, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38366086

4.

Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

Barrett, Christopher D; Neal, Matthew D; Schoenecker, Jonathan G; Medcalf, Robert L; Myles, Paul S.

Transfusion ; 64 Suppl 2: S11-S13, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38461482

5.

Plasminogen: an enigmatic zymogen.

Keragala, Charithani B; Medcalf, Robert L.

Blood ; 137(21): 2881-2889, 2021 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-33735914

6.

Tranexamic acid for haemostasis and beyond: does dose matter?

Lam, Tammy; Medcalf, Robert L; Cloud, Geoffrey C; Myles, Paul S; Keragala, Charithani B.

Thromb J ; 21(1): 94, 2023 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-37700271

7.

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study.

Coupland, Lucy A; Rabbolini, David J; Schoenecker, Jonathan G; Crispin, Philip J; Miller, Jennene J; Ghent, Tony; Medcalf, Robert L; Aneman, Anders E.

Crit Care ; 27(1): 55, 2023 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-36765421

8.

Tranexamic acid alters the immunophenotype of phagocytes after lower limb surgery.

Draxler, Dominik F; Hanafi, Gryselda; Zahra, Saffanah; McCutcheon, Fiona; Ho, Heidi; Keragala, Charithani B; Liu, Zikou; Daly, David; Painter, Thomas; Wallace, Sophia; Plebanski, Magdalena; Myles, Paul S; Medcalf, Robert L.

Thromb J ; 20(1): 17, 2022 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-35410340

9.

Characterisation of Plasma Mitochondrial DNA, MMP-9 and Neutrophil Elastase in Patients Undergoing Coronary Artery Bypass Grafting: Effects of Tranexamic Acid and Postoperative Pneumonia.

Sandler, Nicola; Ho, Heidi; Draxler, Dominik F; Bain, Christopher R; Smith, Julian A; Hauser, Carl J; Gruen, Russell L; Myles, Paul S; Medcalf, Robert L.

Heart Lung Circ ; 31(3): 439-446, 2022 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-34627673

10.

Cerebral Amyloid Angiopathy and the Fibrinolytic System: Is Plasmin a Therapeutic Target?

Mutimer, Chloe A; Keragala, Charithani B; Markus, Hugh S; Werring, David J; Cloud, Geoffrey C; Medcalf, Robert L.

Stroke ; 52(8): 2707-2714, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34126761

11.

Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.

Awad, Milena M; Hutton, Melanie L; Quek, Adam J; Klare, William P; Mileto, Steven J; Mackin, Kate; Ly, Diane; Oorschot, Viola; Bosnjak, Marijana; Jenkin, Grant; Conroy, Paul J; West, Nick; Fulcher, Alex; Costin, Adam; Day, Christopher J; Jennings, Michael P; Medcalf, Robert L; Sanderson-Smith, Martina; Cordwell, Stuart J; Law, Ruby H P; Whisstock, James C; Lyras, Dena.

Gastroenterology ; 159(4): 1431-1443.e6, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32574621

12.

Fibrinolysis: A Primordial System Linked to the Immune Response.

Medcalf, Robert L; Keragala, Charithani B.

Int J Mol Sci ; 22(7)2021 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-33810275

13.

Fibrinolysis and the Immune Response in Trauma.

Medcalf, Robert L; Keragala, Charithani B; Draxler, Dominik F.

Semin Thromb Hemost ; 46(2): 176-182, 2020 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-32069515

14.

Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.

Moore, Hunter B; Moore, Ernest E; Neal, Matthew D; Sheppard, Forest R; Kornblith, Lucy Z; Draxler, Dominik F; Walsh, Mark; Medcalf, Robert L; Cohen, Mitch J; Cotton, Bryan A; Thomas, Scott G; Leeper, Christine M; Gaines, Barbara A; Sauaia, Angela.

Anesth Analg ; 129(3): 762-773, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31425218

15.

Haemostasis and innate immunity - a complementary relationship: A review of the intricate relationship between coagulation and complement pathways.

Keragala, Charithani B; Draxler, Dominik F; McQuilten, Zoe K; Medcalf, Robert L.

Br J Haematol ; 180(6): 782-798, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29265338

16.

Plasmin: A Modulator of Immune Function.

Draxler, Dominik F; Sashindranath, Maithili; Medcalf, Robert L.

Semin Thromb Hemost ; 43(2): 143-153, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-27677178

17.

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.

Fredriksson, Linda; Lawrence, Daniel A; Medcalf, Robert L.

Semin Thromb Hemost ; 43(2): 154-168, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-27677179

18.

The traumatic side of fibrinolysis.

Medcalf, Robert L.

Blood ; 125(16): 2457-8, 2015 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-25883229

19.

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets.

Wang, Xiaowei; Palasubramaniam, Jathushan; Gkanatsas, Yannik; Hohmann, Jan David; Westein, Erik; Kanojia, Ruchi; Alt, Karen; Huang, Dexing; Jia, Fu; Ahrens, Ingo; Medcalf, Robert L; Peter, Karlheinz; Hagemeyer, Christoph E.

Circ Res ; 114(7): 1083-93, 2014 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-24508759

20.

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.

Shultz, Sandy R; Wright, David K; Zheng, Ping; Stuchbery, Ryan; Liu, Shi-Jie; Sashindranath, Maithili; Medcalf, Robert L; Johnston, Leigh A; Hovens, Christopher M; Jones, Nigel C; O'Brien, Terence J.

Brain ; 138(Pt 5): 1297-313, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25771151

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