Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo.

Alonso-Valenteen, Felix; Pacheco, Sayuri; Srinivas, Dustin; Rentsendorj, Altan; Chu, David; Lubow, Jay; Sims, Jessica; Miao, Tianxin; Mikhael, Simoun; Hwang, Jae Youn; Abrol, Ravinder; Medina Kauwe, Lali K.

Nucleic Acids Res ; 47(21): 11020-11043, 2019 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-31617560

2.

Tumor detection and elimination by a targeted gallium corrole.

Agadjanian, Hasmik; Ma, Jun; Rentsendorj, Altan; Valluripalli, Vinod; Hwang, Jae Youn; Mahammed, Atif; Farkas, Daniel L; Gray, Harry B; Gross, Zeev; Medina-Kauwe, Lali K.

Proc Natl Acad Sci U S A ; 106(15): 6105-10, 2009 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-19342490

3.

A mechanistic study of tumor-targeted corrole toxicity.

Hwang, Jae Youn; Lubow, Jay; Chu, David; Ma, Jun; Agadjanian, Hasmik; Sims, Jessica; Gray, Harry B; Gross, Zeev; Farkas, Daniel L; Medina-Kauwe, Lali K.

Mol Pharm ; 8(6): 2233-43, 2011 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-21981771

4.

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles.

Parimon, Tanyalak; Yao, Changfu; Habiel, David M; Ge, Lingyin; Bora, Stephanie A; Brauer, Rena; Evans, Christopher M; Xie, Ting; Alonso-Valenteen, Felix; Medina-Kauwe, Lali K; Jiang, Dianhua; Noble, Paul W; Hogaboam, Cory M; Deng, Nan; Burgy, Olivier; Antes, Travis J; Königshoff, Melanie; Stripp, Barry R; Gharib, Sina A; Chen, Peter.

JCI Insight ; 52019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31393853

5.

Corroles that bind with high affinity to both apo and holo transferrin.

Haber, Adi; Agadjanian, Hasmik; Medina-Kauwe, Lali K; Gross, Zeev.

J Inorg Biochem ; 102(3): 446-57, 2008 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-18180041

6.

Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics.

Sims, Jessica D; Taguiam, Jan Michael; Alonso-Valenteen, Felix; Markman, Janet; Agadjanian, Hasmik; Chu, David; Lubow, Jay; Abrol, Ravinder; Srinivas, Dustin; Jain, Anjali; Han, Bingchen; Qu, Ying; Mirzadehgan, Parisa; Hwang, Jae-Youn; Rentsendorj, Altan; Chung, Alice; Lester, Jenny; Karlan, Beth Y; Gray, Harry B; Gross, Zeev; Giuliano, Armando; Cui, Xiaojiang; Medina-Kauwe, Lali K.

J Control Release ; 271: 127-138, 2018 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-29288681

7.

A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity.

Sims, Jessica D; Hwang, Jae Youn; Wagner, Shawn; Alonso-Valenteen, Felix; Hanson, Chris; Taguiam, Jan Michael; Polo, Richard; Harutyunyan, Ira; Karapetyan, Gevorg; Sorasaenee, Karn; Ibrahim, Ahmed; Marban, Eduardo; Moats, Rex; Gray, Harry B; Gross, Zeev; Medina-Kauwe, Lali K.

J Control Release ; 217: 92-101, 2015 Nov 10.

Artigo em Inglês | MEDLINE | ID: mdl-26334483

8.

Endocytosis of adenovirus and adenovirus capsid proteins.

Medina-Kauwe, Lali K.

Adv Drug Deliv Rev ; 55(11): 1485-96, 2003 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-14597142

9.

Modulation of secretory functions in epithelia by adenovirus capsid proteins.

Hamm-Alvarez, Sarah F; Xie, Jiansong; Wang, Yanru; Medina-Kauwe, Lali K.

J Control Release ; 93(2): 129-40, 2003 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-14636719

10.

Development of adenovirus capsid proteins for targeted therapeutic delivery.

Medina-Kauwe, Lali K.

Ther Deliv ; 4(2): 267-77, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-23343164

11.

Analysis of targeted viral protein nanoparticles delivered to HER2+ tumors.

Hwang, Jae Youn; Farkas, Daniel L; Medina-Kauwe, Lali K.

J Vis Exp ; (76)2013 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-23851334

12.

Fluorescence response of human HER2+ cancer- and MCF-12F normal cells to 200MHz ultrasound microbeam stimulation: a preliminary study of membrane permeability variation.

Hwang, Jae Youn; Lee, Jungwoo; Lee, Changyang; Jakob, Anette; Lemor, Robert; Medina-Kauwe, Lali K; Shung, K Kirk.

Ultrasonics ; 52(7): 803-8, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22513260

13.

Investigating photoexcitation-induced mitochondrial damage by chemotherapeutic corroles using multimode optical imaging.

Hwang, Jae Youn; Lubow, David J; Sims, Jessica D; Gray, Harry B; Mahammed, Atif; Gross, Zeev; Medina-Kauwe, Lali K; Farkas, Daniel L.

J Biomed Opt ; 17(1): 015003, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22352647

14.

Chemotherapy targeting by DNA capture in viral protein particles.

Agadjanian, Hasmik; Chu, David; Hwang, Jae Youn; Wachsmann-Hogiu, Sebastian; Rentsendorj, Altan; Song, Lei; Valluripalli, Vinod; Lubow, Jay; Ma, Jun; Sharifi, Behrooz; Farkas, Daniel L; Medina-Kauwe, Lali K.

Nanomedicine (Lond) ; 7(3): 335-52, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22385197

15.

A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment.

Hwang, Jae Youn; Wachsmann-Hogiu, Sebastian; Ramanujan, V Krishnan; Ljubimova, Julia; Gross, Zeev; Gray, Harry B; Medina-Kauwe, Lali K; Farkas, Daniel L.

Mol Imaging Biol ; 14(4): 431-42, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21874388

16.

Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity.

Hwang, Jae Youn; Lubow, David J; Chu, David; Sims, Jessica; Alonso-Valenteen, Felix; Gray, Harry B; Gross, Zeev; Farkas, Daniel L; Medina-Kauwe, Lali K.

J Control Release ; 163(3): 368-73, 2012 Nov 10.

Artigo em Inglês | MEDLINE | ID: mdl-23041277

17.

Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles.

Hwang, Jae Youn; Park, Jinhyoung; Kang, Bong Jin; Lubow, David J; Chu, David; Farkas, Daniel L; Shung, K Kirk; Medina-Kauwe, Lali K.

PLoS One ; 7(4): e34463, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22509306

18.

Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo.

Hwang, Jae Youn; Gross, Zeev; Gray, Harry B; Medina-Kauwe, Lali K; Farkas, Daniel L.

J Biomed Opt ; 16(6): 066007, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21721808

19.

Investigating the photosensitizer-potential of targeted gallium corrole using multimode optical imaging.

Hwang, Jae Youn; Lubow, Jay; Chu, David; Gross, Zeev; Gray, Harry B; Farkas, Daniel L; Medina-Kauwe, Lali K.

Proc SPIE Int Soc Opt Eng ; 78862011 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-26028799

20.

Multimode Optical Imaging for Translational Chemotherapy: In Vivo Tumor Detection and Delineation by Targeted Gallium Corroles.