Detalhe da pesquisa
1.
Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs.
J Pharmacol Exp Ther
; 349(1): 138-54, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24421319
2.
Differential interaction of neuroleptics with apomorphine-induced behavior in rats as a function of changing levels of dopamine receptor stimulation.
J Pharmacol Exp Ther
; 347(3): 681-96, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24071734
3.
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
J Pharmacol Exp Ther
; 346(3): 514-27, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23766542
4.
Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia.
J Pharmacol Exp Ther
; 342(1): 91-105, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22490380
5.
Gavage-related reflux in rats: identification, pathogenesis, and toxicological implications (review).
Toxicol Pathol
; 39(2): 348-60, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21422261
6.
Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain.
Nucl Med Commun
; 29(8): 724-9, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18753826
7.
Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior.
Eur J Pharm Sci
; 32(3): 200-8, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17825539
8.
Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice.
Behav Brain Res
; 172(1): 122-34, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16764948
9.
Lipophilic nalmefene prodrugs to achieve a one-month sustained release.
J Control Release
; 232: 196-202, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27107723
10.
Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
J Med Chem
; 48(6): 2154-66, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771458
11.
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
J Med Chem
; 48(6): 1709-12, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771415
12.
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
J Med Chem
; 48(6): 2054-71, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771448
13.
Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test.
Psychopharmacology (Berl)
; 179(1): 198-206, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15821950
14.
Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring.
Farmaco
; 60(3): 241-8, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15784244
15.
Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813.
Pharmacol Res Perspect
; 3(2): e00097, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25692027
16.
Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.
J Med Chem
; 58(2): 978-93, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25495129
17.
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.
ACS Med Chem Lett
; 6(6): 716-20, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26157544
18.
Does phenylethylamine act as an endogenous amphetamine in some patients?
Int J Neuropsychopharmacol
; 2(3): 229-240, 1999 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-11281991
19.
PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways.
Pharmacol Res Perspect
; 2(4): e00057, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25505601
20.
mGlu(2) receptor-mediated modulation of conditioned avoidance behavior in rats.
Eur J Pharmacol
; 727: 130-9, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24486391