Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.

Horan, Kristy A; Hansen, Kathrine; Jakobsen, Martin R; Holm, Christian K; Søby, Stine; Unterholzner, Leonie; Thompson, Mikayla; West, John A; Iversen, Marie B; Rasmussen, Simon B; Ellermann-Eriksen, Svend; Kurt-Jones, Evelyn; Landolfo, Santo; Damania, Blossom; Melchjorsen, Jesper; Bowie, Andrew G; Fitzgerald, Katherine A; Paludan, Søren R.

J Immunol ; 190(5): 2311-9, 2013 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-23345332

2.

Sensing herpes: more than toll.

Melchjorsen, Jesper.

Rev Med Virol ; 22(2): 106-21, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22020814

3.

Characterization of HIV-1 infection and innate sensing in different types of primary human monocyte-derived macrophages.

Diget, Elisabeth A; Zuwala, Kaja; Berg, Randi K; Laursen, Rune R; Søby, Stine; Østergaard, Lars; Melchjorsen, Jesper; Mogensen, Trine H.

Mediators Inflamm ; 2013: 208412, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23431237

4.

Timing of Toll-like receptor 9 agonist administration in pneumococcal vaccination impacts both humoral and cellular immune responses as well as nasopharyngeal colonization in mice.

Jensen, Katrine M; Melchjorsen, Jesper; Dagnaes-Hansen, Frederik; Sørensen, Uffe B S; Laursen, Rune R; Østergaard, Lars; Søgaard, Ole S; Tolstrup, Martin.

Infect Immun ; 80(5): 1744-52, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22371375

5.

Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs.

Iversen, Marie B; Ank, Nina; Melchjorsen, Jesper; Paludan, Søren R.

J Virol ; 84(9): 4579-86, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20181703

6.

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways.

Melchjorsen, Jesper; Rintahaka, Johanna; Søby, Stine; Horan, Kristy A; Poltajainen, Alina; Østergaard, Lars; Paludan, Søren R; Matikainen, Sampsa.

J Virol ; 84(21): 11350-8, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20739519

7.

Induction of humoral and cellular immune responses against the HIV-1 envelope protein using Î³-retroviral virus-like particles.

Kirkegaard, Tea; Wheatley, Adam; Melchjorsen, Jesper; Bahrami, Shervin; Pedersen, Finn S; Center, Robert J; Purcell, Damian F J; Ostergaard, Lars; Duch, Mogens; Tolstrup, Martin.

Virol J ; 8: 381, 2011 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-21806819

8.

Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy.

Rasmussen, Thomas A; Tolstrup, Martin; Melchjorsen, Jesper; Frederiksen, Christian A; Nielsen, Ulla S; Langdahl, Bente L; Østergaard, Lars; Laursen, Alex L.

BMC Infect Dis ; 11: 267, 2011 Oct 04.

Artigo em Inglês | MEDLINE | ID: mdl-21970555

9.

Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes.

Ohman, Tiina; Lietzén, Niina; Välimäki, Elina; Melchjorsen, Jesper; Matikainen, Sampsa; Nyman, Tuula A.

J Proteome Res ; 9(3): 1549-64, 2010 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-20070120

10.

Innate immune recognition and activation during HIV infection.

Mogensen, Trine H; Melchjorsen, Jesper; Larsen, Carsten S; Paludan, Søren R.

Retrovirology ; 7: 54, 2010 Jun 22.

Artigo em Inglês | MEDLINE | ID: mdl-20569472

11.

Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function.

Melchjorsen, Jesper; Sørensen, Louise N; Paludan, Søren R.

J Leukoc Biol ; 74(3): 331-43, 2003 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-12949236

12.

Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells.

Ruiz-Sanchis, Pau; Wohl, Benjamin M; Smith, Anton A A; Zuwala, Kaja; Melchjorsen, Jesper; Tolstrup, Martin; Zelikin, Alexander N.

Adv Healthc Mater ; 4(1): 65-8, 2015 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-25132665

13.

Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis.

Zuwala, Kaja; Smith, Anton A A; Postma, Almar; Guerrero-Sanchez, Carlos; Ruiz-Sanchis, Pau; Melchjorsen, Jesper; Tolstrup, Martin; Zelikin, Alexander N.

Adv Healthc Mater ; 4(1): 46-50, 2015 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-24811313

14.

Expression of genes for cytokines and cytokine-related functions in leukocytes infected with Herpes simplex virus: comparison between resistant and susceptible mouse strains.

Paludan, Søren R; Melchjorsen, Jesper; Malmgaard, Lene; Mogensen, Søren C.

Eur Cytokine Netw ; 13(3): 306-16, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12231474

15.

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.

Berg, Randi K; Rahbek, Stine H; Kofod-Olsen, Emil; Holm, Christian K; Melchjorsen, Jesper; Jensen, David G; Hansen, Anne Louise; Jørgensen, Louise B; Ostergaard, Lars; Tolstrup, Martin; Larsen, Carsten S; Paludan, Søren R; Jakobsen, Martin R; Mogensen, Trine H.

PLoS One ; 9(1): e84513, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24404168

16.

Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.

Melchjorsen, Jesper.

Viruses ; 5(2): 470-527, 2013 Jan 31.

Artigo em Inglês | MEDLINE | ID: mdl-23435233

17.

Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation.

Rasmussen, Thomas Aagaard; Schmeltz Søgaard, Ole; Brinkmann, Christel; Wightman, Fiona; Lewin, Sharon R; Melchjorsen, Jesper; Dinarello, Charles; Østergaard, Lars; Tolstrup, Martin.

Hum Vaccin Immunother ; 9(5): 993-1001, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23370291

18.

Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients.

Winckelmann, Anni A; Munk-Petersen, Lærke V; Rasmussen, Thomas A; Melchjorsen, Jesper; Hjelholt, Thomas J; Montefiori, David; Østergaard, Lars; Søgaard, Ole S; Tolstrup, Martin.

PLoS One ; 8(4): e62074, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23637967

19.

HSV-1-induced chemokine expression via IFI16-dependent and IFI16-independent pathways in human monocyte-derived macrophages.

Søby, Stine; Laursen, Rune R; Østergaard, Lars; Melchjorsen, Jesper.

Herpesviridae ; 3(1): 6, 2012 Oct 14.

Artigo em Inglês | MEDLINE | ID: mdl-23062757

20.

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults.

Offersen, Rasmus; Melchjorsen, Jesper; Paludan, Søren R; Østergaard, Lars; Tolstrup, Martin; Søgaard, Ole S.

Hum Vaccin Immunother ; 8(8): 1042-7, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22854665

BVS Doenças Infecciosas e Parasitárias

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