Detalhe da pesquisa
1.
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins.
Cell
; 182(2): 345-356.e16, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32589945
2.
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis.
Proc Natl Acad Sci U S A
; 120(19): e2301252120, 2023 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37126691
3.
Translocation expands the scope of the large clostridial toxin family.
Trends Biochem Sci
; 46(12): 953-959, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34429235
4.
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
Proc Natl Acad Sci U S A
; 117(29): 16938-16948, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32616570
5.
Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin.
Proc Natl Acad Sci U S A
; 117(12): 6792-6800, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32152097
6.
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).
Proc Natl Acad Sci U S A
; 117(11): 5791-5800, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123106
7.
Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis.
Infect Immun
; 90(8): e0015322, 2022 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862710
8.
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells.
Antimicrob Agents Chemother
; 66(7): e0043922, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35703551
9.
The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.
PLoS Pathog
; 16(9): e1008852, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32960931
10.
Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.
Gastroenterology
; 158(4): 1000-1015, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31743734
11.
Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.
Crit Rev Biochem Mol Biol
; 52(4): 461-473, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545305
12.
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J Biol Chem
; 293(3): 941-952, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180448
13.
Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
J Biol Chem
; 292(42): 17290-17301, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28842504
14.
Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors.
J Antimicrob Chemother
; 73(1): 109-117, 2018 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29029095
15.
Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.
Mol Pharm
; 15(11): 5217-5226, 2018 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30212635
16.
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.
Proc Natl Acad Sci U S A
; 111(10): 3721-6, 2014 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24567384
17.
Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.
J Biol Chem
; 290(3): 1474-84, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355312
18.
Efficient Delivery of Structurally Diverse Protein Cargo into Mammalian Cells by a Bacterial Toxin.
Mol Pharm
; 12(8): 2962-71, 2015 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26103531
19.
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.
Microbiol Spectr
; 11(3): e0029623, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098898
20.
A designer peptide against the EAG2-Kvß2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma.
Nat Cancer
; 4(10): 1418-1436, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37697045