Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.

Praetorius, Christian; Grill, Christine; Stacey, Simon N; Metcalf, Alexander M; Gorkin, David U; Robinson, Kathleen C; Van Otterloo, Eric; Kim, Reuben S Q; Bergsteinsdottir, Kristin; Ogmundsdottir, Margret H; Magnusdottir, Erna; Mishra, Pravin J; Davis, Sean R; Guo, Theresa; Zaidi, M Raza; Helgason, Agnar S; Sigurdsson, Martin I; Meltzer, Paul S; Merlino, Glenn; Petit, Valerie; Larue, Lionel; Loftus, Stacie K; Adams, David R; Sobhiafshar, Ulduz; Emre, N C Tolga; Pavan, William J; Cornell, Robert; Smith, Aaron G; McCallion, Andrew S; Fisher, David E; Stefansson, Kari; Sturm, Richard A; Steingrimsson, Eirikur.

Cell ; 155(5): 1022-33, 2013 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-24267888

2.

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen, Niek; Sridharan, Sriram; Nathan, William J; Tubbs, Anthony; Chan, Edmond M; Callen, Elsa; Wu, Wei; Belinky, Frida; Tripathi, Veenu; Wong, Nancy; Foster, Kyla; Noorbakhsh, Javad; Garimella, Kiran; Cruz-Migoni, Abimael; Sommers, Joshua A; Huang, Yongqing; Borah, Ashir A; Smith, Jonathan T; Kalfon, Jeremie; Kesten, Nikolas; Fugger, Kasper; Walker, Robert L; Dolzhenko, Egor; Eberle, Michael A; Hayward, Bruce E; Usdin, Karen; Freudenreich, Catherine H; Brosh, Robert M; West, Stephen C; McHugh, Peter J; Meltzer, Paul S; Bass, Adam J; Nussenzweig, André.

Nature ; 586(7828): 292-298, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32999459

3.

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

Ma, Xiaotu; Liu, Yu; Liu, Yanling; Alexandrov, Ludmil B; Edmonson, Michael N; Gawad, Charles; Zhou, Xin; Li, Yongjin; Rusch, Michael C; Easton, John; Huether, Robert; Gonzalez-Pena, Veronica; Wilkinson, Mark R; Hermida, Leandro C; Davis, Sean; Sioson, Edgar; Pounds, Stanley; Cao, Xueyuan; Ries, Rhonda E; Wang, Zhaoming; Chen, Xiang; Dong, Li; Diskin, Sharon J; Smith, Malcolm A; Guidry Auvil, Jaime M; Meltzer, Paul S; Lau, Ching C; Perlman, Elizabeth J; Maris, John M; Meshinchi, Soheil; Hunger, Stephen P; Gerhard, Daniela S; Zhang, Jinghui.

Nature ; 555(7696): 371-376, 2018 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-29489755

4.

Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.

Matsukawa, Toshihiro; Yin, Mianmian; Baslan, Timour; Chung, Yang Jo; Cao, Dengchao; Bertoli, Ryan; Zhu, Yuelin J; Walker, Robert L; Freeland, Amy; Knudsen, Erik; Lowe, Scott W; Meltzer, Paul S; Aplan, Peter D.

FASEB J ; 36(9): e22430, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35920299

5.

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Au, Wei-Chun; Zhang, Tianyi; Mishra, Prashant K; Eisenstatt, Jessica R; Walker, Robert L; Ocampo, Josefina; Dawson, Anthony; Warren, Jack; Costanzo, Michael; Baryshnikova, Anastasia; Flick, Karin; Clark, David J; Meltzer, Paul S; Baker, Richard E; Myers, Chad; Boone, Charles; Kaiser, Peter; Basrai, Munira A.

PLoS Genet ; 16(2): e1008597, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-32032354

6.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham, Jinu; Nuñez-Álvarez, Yaiza; Hettmer, Simone; Carrió, Elvira; Chen, Hung-I Harry; Nishijo, Koichi; Huang, Elaine T; Prajapati, Suresh I; Walker, Robert L; Davis, Sean; Rebeles, Jennifer; Wiebush, Hunter; McCleish, Amanda T; Hampton, Sheila T; Bjornson, Christopher R R; Brack, Andrew S; Wagers, Amy J; Rando, Thomas A; Capecchi, Mario R; Marini, Frank C; Ehler, Benjamin R; Zarzabal, Lee Ann; Goros, Martin W; Michalek, Joel E; Meltzer, Paul S; Langenau, David M; LeGallo, Robin D; Mansoor, Atiya; Chen, Yidong; Suelves, Mònica; Rubin, Brian P; Keller, Charles.

Genes Dev ; 28(14): 1578-91, 2014 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-25030697

7.

Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines.

Yang, Youfeng; Ricketts, Christopher J; Vocke, Cathy D; Killian, J Keith; Padilla-Nash, Hesed M; Lang, Martin; Wei, Darmood; Lee, Young H; Wangsa, Darawalee; Sourbier, Carole; Meltzer, Paul S; Ried, Thomas; Merino, Maria J; Metwalli, Adam R; Ball, Mark W; Srinivasan, Ramaprasad; Linehan, W Marston.

Genes Chromosomes Cancer ; 60(6): 434-446, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33527590

8.

Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies.

Azorsa, David O; Bode, Peter K; Wachtel, Marco; Cheuk, Adam Tai Chi; Meltzer, Paul S; Vokuhl, Christian; Camenisch, Ulrike; Khov, Huy Leng; Bode, Beata; Schäfer, Beat W; Khan, Javed.

Mod Pathol ; 34(4): 748-757, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33299109

9.

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.

Yin, Mianmian; Chung, Yang Jo; Lindsley, R Coleman; Walker, Robert L; Zhu, Yuelin J; Ebert, Benjamin L; Meltzer, Paul S; Aplan, Peter D.

Blood ; 133(24): 2610-2614, 2019 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-30992267

10.

Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments.

Wei, Darmood; Yang, Youfeng; Ricketts, Christopher J; Vocke, Cathy D; Ball, Mark W; Sourbier, Carole; Wangsa, Darawalee; Wangsa, Danny; Guha, Rajarshi; Zhang, Xiaohu; Wilson, Kelli; Chen, Lu; Meltzer, Paul S; Ried, Thomas; Thomas, Craig J; Merino, Maria J; Linehan, W Marston.

Genes Chromosomes Cancer ; 59(8): 472-483, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32259323

11.

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.

Sun, Wenyue; Chatterjee, Bishwanath; Shern, Jack F; Patidar, Rajesh; Song, Young; Wang, Yonghong; Walker, Robert L; Pawel, Bruce R; Linardic, Corinne M; Houghton, Peter; Hewitt, Stephen M; Edelman, Daniel C; Khan, Javed; Meltzer, Paul S; Barr, Frederic G.

Int J Cancer ; 144(11): 2707-2717, 2019 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-30565669

12.

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.

Roberts, Ryan D; Lizardo, Michael M; Reed, Damon R; Hingorani, Pooja; Glover, Jason; Allen-Rhoades, Wendy; Fan, Timothy; Khanna, Chand; Sweet-Cordero, E Alejandro; Cash, Thomas; Bishop, Michael W; Hegde, Meenakshi; Sertil, Aparna R; Koelsche, Christian; Mirabello, Lisa; Malkin, David; Sorensen, Poul H; Meltzer, Paul S; Janeway, Katherine A; Gorlick, Richard; Crompton, Brian D.

Cancer ; 125(20): 3514-3525, 2019 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-31355930

13.

New Horizons in the Treatment of Osteosarcoma.

Meltzer, Paul S; Helman, Lee J.

N Engl J Med ; 385(22): 2066-2076, 2021 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-34818481

14.

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.

Killian, J Keith; Dorssers, Lambert C J; Trabert, Britton; Gillis, Ad J M; Cook, Michael B; Wang, Yonghong; Waterfall, Joshua J; Stevenson, Holly; Smith, William I; Noyes, Natalia; Retnakumar, Parvathy; Stoop, J Hans; Oosterhuis, J Wolter; Meltzer, Paul S; McGlynn, Katherine A; Looijenga, Leendert H J.

Genome Res ; 26(11): 1490-1504, 2016 11.

Artigo em Inglês | MEDLINE | ID: mdl-27803193

15.

Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.

Oltmann, Johanna; Heselmeyer-Haddad, Kerstin; Hernandez, Leanora S; Meyer, Rüdiger; Torres, Irianna; Hu, Yue; Doberstein, Natalie; Killian, J Keith; Petersen, David; Zhu, Yuelin Jack; Edelman, Daniel C; Meltzer, Paul S; Schwartz, Russell; Gertz, E Michael; Schäffer, Alejandro A; Auer, Gert; Habermann, Jens K; Ried, Thomas.

Genes Chromosomes Cancer ; 57(4): 165-175, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29181861

16.

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.

Goldberg, Liat; Gough, Sheryl M; Lee, Fan; Dang, Christine; Walker, Robert L; Zhu, Yuelin J; Bilke, Sven; Pineda, Marbin; Onozawa, Masahiro; Jo Chung, Yang; Meltzer, Paul S; Aplan, Peter D.

Genes Chromosomes Cancer ; 56(6): 472-483, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28196408

17.

Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).

Yang, Youfeng; Vocke, Cathy D; Ricketts, Christopher J; Wei, Darmood; Padilla-Nash, Hesed M; Lang, Martin; Sourbier, Carole; Killian, J Keith; Boyle, Shawna L; Worrell, Robert; Meltzer, Paul S; Ried, Thomas; Merino, Maria J; Metwalli, Adam R; Linehan, W Marston.

Genes Chromosomes Cancer ; 56(10): 719-729, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28736828

18.

Interferon-Î³ links ultraviolet radiation to melanomagenesis in mice.

Zaidi, M Raza; Davis, Sean; Noonan, Frances P; Graff-Cherry, Cari; Hawley, Teresa S; Walker, Robert L; Feigenbaum, Lionel; Fuchs, Elaine; Lyakh, Lyudmila; Young, Howard A; Hornyak, Thomas J; Arnheiter, Heinz; Trinchieri, Giorgio; Meltzer, Paul S; De Fabo, Edward C; Merlino, Glenn.

Nature ; 469(7331): 548-53, 2011 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-21248750

19.

Integrated genome-wide analysis of genomic changes and gene regulation in human adrenocortical tissue samples.

Gara, Sudheer Kumar; Wang, Yonghong; Patel, Dhaval; Liu-Chittenden, Yi; Jain, Meenu; Boufraqech, Myriem; Zhang, Lisa; Meltzer, Paul S; Kebebew, Electron.

Nucleic Acids Res ; 43(19): 9327-39, 2015 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-26446994

20.

EWS-FLI1 employs an E2F switch to drive target gene expression.

Schwentner, Raphaela; Papamarkou, Theodore; Kauer, Maximilian O; Stathopoulos, Vassilios; Yang, Fan; Bilke, Sven; Meltzer, Paul S; Girolami, Mark; Kovar, Heinrich.

Nucleic Acids Res ; 43(5): 2780-9, 2015 Mar 11.

Artigo em Inglês | MEDLINE | ID: mdl-25712098

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