RESUMO
The Desmodus rotundus endogenous betaretrovirus (DrERV) is fixed in the vampire bat D. rotundus population and in other phyllostomid bats but is not present in all species from this family. DrERV is not phylogenetically related to Old World bat betaretroviruses but to betaretroviruses from rodents and New World primates, suggesting recent cross-species transmission. A recent integration age estimation of the provirus in some taxa indicates that an exogenous counterpart might have been in recent circulation.
Assuntos
Betaretrovirus/classificação , Quirópteros/genética , Quirópteros/virologia , Retrovirus Endógenos/classificação , Filogenia , Infecções por Retroviridae/veterinária , Animais , Betaretrovirus/genética , Betaretrovirus/isolamento & purificação , Retrovirus Endógenos/genética , Retrovirus Endógenos/isolamento & purificação , Ordem dos Genes , Primatas/virologia , Infecções por Retroviridae/virologia , Roedores/virologia , SinteniaRESUMO
The human genome reference assembly is crucial for aligning and analyzing sequence data, and for genome annotation, among other roles. However, the models and analysis assumptions that underlie the current assembly need revising to fully represent human sequence diversity. Improved analysis tools and updated data reporting formats are also required.