Detalhe da pesquisa
1.
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution.
Proc Natl Acad Sci U S A
; 120(35): e2302070120, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37603745
2.
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation.
J Am Chem Soc
; 145(27): 14802-14810, 2023 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37385602
3.
Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.
J Lipid Res
; 63(12): 100310, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36370807
4.
Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ.
J Biol Chem
; 297(1): 100814, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081964
5.
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
Bioorg Chem
; 129: 106164, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36162288
6.
Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists.
Int J Mol Sci
; 23(17)2022 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077469
7.
A Consensus Compound/Bioactivity Dataset for Data-Driven Drug Design and Chemogenomics.
Molecules
; 27(8)2022 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458710
8.
Biological evaluation and synthesis of calcitroic acid.
Bioorg Chem
; 116: 105310, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482171
9.
Beam Search for Automated Design and Scoring of Novel ROR Ligands with Machine Intelligence*.
Angew Chem Int Ed Engl
; 60(35): 19477-19482, 2021 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165856
10.
The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
Dev Neurosci
; 42(5-6): 170-186, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472197
11.
Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics.
Int J Mol Sci
; 21(21)2020 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33114319
12.
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Int J Mol Sci
; 21(22)2020 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33187070
13.
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
Acta Neuropathol
; 137(4): 657-673, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30830316
14.
Structure optimization of a new class of PPARγ antagonists.
Bioorg Med Chem
; 27(21): 115082, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548084
15.
Remote Sensing of Droplet Number Concentration in Warm Clouds: A Review of the Current State of Knowledge and Perspectives.
Rev Geophys
; 56(2): 409-453, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30148283
16.
Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists.
Bioorg Med Chem
; 26(14): 4240-4253, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30026040
17.
DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Bioorg Med Chem Lett
; 27(5): 1193-1198, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169169
18.
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.
Bioorg Med Chem
; 23(3): 499-514, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583100
19.
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.
Bioorg Med Chem
; 23(13): 3490-8, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25934227
20.
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).
Bioorg Med Chem
; 22(8): 2447-60, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685112