Detalhe da pesquisa
1.
Climate research priorities for policy-makers, practitioners, and scientists in Georgia, USA.
Environ Manage
; 62(2): 190-209, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29796704
2.
SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
Bioorg Med Chem Lett
; 22(4): 1633-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22281189
3.
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management.
Bioorg Med Chem Lett
; 22(7): 2604-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370265
4.
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
J Pharmacol Exp Ther
; 334(3): 863-74, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20504915
5.
Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.
J Pharmacol Exp Ther
; 328(1): 141-51, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18931146
6.
Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.
J Neurosci
; 27(39): 10578-87, 2007 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17898229
7.
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
J Med Chem
; 51(6): 1904-12, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18311894
8.
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
J Med Chem
; 50(22): 5493-508, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17929796
9.
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
J Med Chem
; 50(15): 3627-44, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17585748
10.
A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.
Biochem Pharmacol
; 74(8): 1253-62, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17854775
11.
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.
J Med Chem
; 49(26): 7843-53, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181167
12.
High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs.
J Mol Neurosci
; 30(1-2): 11-2, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17192606
13.
Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain.
Neurosci Lett
; 376(1): 29-34, 2005 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15694269
14.
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain.
Pain
; 103(3): 269-276, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12791433
15.
A-186253, a specific antagonist of the alpha 4 beta 2 nAChRs: its properties and potential to study brain nicotinic acetylcholine receptors.
Neuropharmacology
; 47(4): 538-57, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380372
16.
Conformationally constrained nicotines: polycyclic, bridged, and spiro-annulated analogues as novel ligands for the nicotinic acetylcholine receptor.
J Med Chem
; 45(18): 4047-54, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190326
17.
6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies.
J Med Chem
; 45(18): 4011-7, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190322
18.
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
J Med Chem
; 45(20): 4395-7, 2002 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12238918
19.
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
J Med Chem
; 47(12): 3220-35, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15163201
20.
ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes.
Eur J Pharmacol
; 449(1-2): 159-65, 2002 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12163120