Detalhe da pesquisa
1.
Design and synthesis of peptides as stabilizers of histone deacetylase 4.
J Pept Sci
; : e3603, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38623824
2.
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.
Nucleic Acids Res
; 50(5): 2566-2586, 2022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35150567
3.
Rapid Determination of Kinetic Constants for Slow-Binding Inhibitors and Inactivators of Human Histone Deacetylase 8.
Int J Mol Sci
; 25(11)2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38891780
4.
Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity.
Int J Mol Sci
; 24(13)2023 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446224
5.
Significance of Five-Membered Heterocycles in Human Histone Deacetylase Inhibitors.
Molecules
; 28(15)2023 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37570656
6.
3-Chloro-5-Substituted-1,2,4-Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers.
Chembiochem
; 23(21): e202200417, 2022 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36066474
7.
Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors.
Int J Mol Sci
; 23(19)2022 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36233076
8.
Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids.
Beilstein J Org Chem
; 18: 837-844, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35923158
9.
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.
Chembiochem
; 22(4): 743-753, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030752
10.
Double-edged Swords: Diaryl pyrazoline thiazolidinediones synchronously targeting cancer epigenetics and angiogenesis.
Bioorg Chem
; 116: 105350, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34547645
11.
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy.
Bioorg Chem
; 107: 104527, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33317839
12.
Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases.
Molecules
; 26(17)2021 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500583
13.
Switching the Switch: Ligand Induced Disulfide Formation in HDAC8.
Chemistry
; 26(58): 13249-13255, 2020 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32428298
14.
Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation.
Bioorg Chem
; 100: 103934, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32446120
15.
Kinetically selective and potent inhibitors of HDAC8.
Biol Chem
; 400(6): 733-743, 2019 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521473
16.
A Fluorescence-Lifetime-Based Binding Assay for Classâ IIa Histone Deacetylases.
Chemistry
; 23(13): 3107-3116, 2017 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27922200
17.
The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket.
Biochim Biophys Acta Gen Subj
; 1861(7): 1855-1863, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389333
18.
Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.
Bioorg Med Chem Lett
; 27(7): 1508-1512, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28259626
19.
Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.
Biochemistry
; 55(49): 6858-6868, 2016 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27951649
20.
Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa.
BMC Biochem
; 17: 4, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956223