1.
Bioorg Med Chem
; 10(11): 3649-61, 2002 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12213481
RESUMO
Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.