Detalhe da pesquisa
1.
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature
; 626(7997): 194-206, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096902
2.
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
Bioorg Med Chem Lett
; 73: 128891, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35842205
3.
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes.
Diabetes Obes Metab
; 22(10): 1827-1836, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32476252
4.
MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL.
Br J Haematol
; 184(6): 925-936, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30537114
5.
Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study.
Hepatology
; 66(2): 324-334, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28470676
6.
Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.
Br J Haematol
; 177(2): 271-282, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28295194
7.
Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation.
J Neurosci
; 35(38): 13124-32, 2015 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26400942
8.
The DcpS inhibitor RG3039 improves motor function in SMA mice.
Hum Mol Genet
; 22(20): 4074-83, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23727836
9.
Epigenetic therapy for Friedreich ataxia.
Ann Neurol
; 76(4): 489-508, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25159818
10.
Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model.
Pharm Res
; 31(3): 635-48, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24190631
11.
Unique Reduced-Intensity Conditioning Haploidentical Peripheral Blood Stem Cell Transplantation Protocol for Patients with Hematologic Malignancy.
Transplant Cell Ther
; 29(5): 331.e1-331.e8, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36775200
12.
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J Med Chem
; 66(15): 10473-10496, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37427891
13.
TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
J Clin Invest
; 130(4): 1863-1878, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32149730
14.
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
Cell Metab
; 29(1): 174-182.e5, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30244972
15.
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3.
Bioorg Med Chem Lett
; 18(5): 1573-6, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242988
16.
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.
Bioorg Med Chem Lett
; 18(7): 2414-9, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18337097
17.
Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.
J Exp Med
; 212(13): 2189-201, 2015 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26621451
18.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
MAbs
; 5(6): 882-95, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23995618
19.
A human CXCL13-induced actin polymerization assay measured by fluorescence plate reader.
Assay Drug Dev Technol
; 8(1): 73-84, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20085454
20.
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).
Bioorg Med Chem Lett
; 14(14): 3721-5, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203150