Detalhe da pesquisa
1.
The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity.
Biochem Biophys Res Commun
; 716: 150011, 2024 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38704890
2.
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers.
Invest New Drugs
; 39(5): 1213-1221, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33710464
3.
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors.
Bioorg Med Chem Lett
; 31: 127710, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33246105
4.
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction.
Invest New Drugs
; 38(3): 700-713, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31267379
5.
Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp.
Bioorg Chem
; 103: 104223, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891002
6.
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
Int J Cancer
; 145(3): 714-727, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30675909
7.
Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis.
Bioorg Med Chem Lett
; 29(2): 185-188, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528697
8.
Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa.
Mar Drugs
; 17(1)2019 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30654446
9.
Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.
Cancer Sci
; 109(3): 821-831, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29274141
10.
Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata.
J Nat Prod
; 81(9): 1976-1983, 2018 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30169038
11.
Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina.
Planta Med
; 84(15): 1127-1133, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29689587
12.
Corrigendum to "Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors" [Bioorg. Med. Chem. Lett. 31 (2021) 127710].
Bioorg Med Chem Lett
; 56: 128501, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34911648
13.
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells.
Acta Pharmacol Sin
; 38(12): 1642-1654, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28713155
14.
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.
Acta Pharmacol Sin
; 38(11): 1521-1532, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28770827
15.
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors.
Acta Pharmacol Sin
; 38(7): 1038-1047, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28414200
16.
Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.
Biochem Pharmacol
; 223: 116198, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588830
17.
Multi-drug-resistant cells enriched from chronic myeloid leukemia cells by Doxorubicin possess tumor-initiating-cell properties.
J Pharmacol Sci
; 122(4): 299-304, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23903006
18.
Marine-derived angiogenesis inhibitors for cancer therapy.
Mar Drugs
; 11(3): 903-33, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23502698
19.
Proteasome inhibitors reduce CD73 expression partly via decreasing p-ERK in NSCLC cells.
Life Sci
; 332: 122129, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37769804
20.
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities.
Eur J Med Chem
; 259: 115709, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37567056