Detalhe da pesquisa
1.
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Int J Mol Sci
; 24(11)2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298645
2.
Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
Int J Mol Sci
; 24(17)2023 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37686209
3.
Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.
Oncology
; 94(3): 176-189, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29306943
4.
Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.
J Biol Chem
; 291(27): 14012-14022, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189943
5.
A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.
Hum Mol Genet
; 23(19): 5123-32, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24838285
6.
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
Hum Mol Genet
; 23(19): 5109-22, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24838286
7.
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
Biochemistry
; 54(45): 6756-9, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26497600
8.
Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.
Methods
; 68(3): 536-41, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24798811
9.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
bioRxiv
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712135
10.
Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease.
Gastro Hep Adv
; 3(1): 67-77, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38292457
11.
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis.
J Biol Chem
; 287(11): 8082-91, 2012 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22262857
12.
Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.
Lab Chip
; 23(20): 4514-4527, 2023 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37766577
13.
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.
Metabolites
; 12(6)2022 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35736460
14.
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Commun Biol
; 5(1): 47, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35022507
15.
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors.
Exp Biol Med (Maywood)
; 246(22): 2420-2441, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33957803
16.
Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System.
Sci Rep
; 9(1): 8341, 2019 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31171849
17.
The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.
Genetics
; 200(1): 207-19, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25786854
18.
Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency.
PLoS One
; 10(10): e0141542, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26512890
19.
A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
PLoS One
; 7(7): e40145, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22768338
20.
Using C. elegans to identify the protease targets of serpins in vivo.
Methods Enzymol
; 499: 283-99, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21683259