Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A cryptic plasmid is among the most numerous genetic elements in the human gut.

Fogarty, Emily C; Schechter, Matthew S; Lolans, Karen; Sheahan, Madeline L; Veseli, Iva; Moore, Ryan M; Kiefl, Evan; Moody, Thomas; Rice, Phoebe A; Yu, Michael K; Mimee, Mark; Chang, Eugene B; Ruscheweyh, Hans-Joachim; Sunagawa, Shinichi; Mclellan, Sandra L; Willis, Amy D; Comstock, Laurie E; Eren, A Murat.

Cell ; 187(5): 1206-1222.e16, 2024 Feb 29.

Artigo em Inglês | MEDLINE | ID: mdl-38428395

2.

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis.

Yehl, Kevin; Lemire, Sébastien; Yang, Andrew C; Ando, Hiroki; Mimee, Mark; Torres, Marcelo Der Torossian; de la Fuente-Nunez, Cesar; Lu, Timothy K.

Cell ; 179(2): 459-469.e9, 2019 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-31585083

3.

Genetic Engineering of Resident Bacteria in the Gut Microbiome.

Arnold, Jack; Glazier, Joshua; Mimee, Mark.

J Bacteriol ; 205(7): e0012723, 2023 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-37382533

4.

Cell-based biosensors for immunology, inflammation, and allergy.

Inda, Maria Eugenia; Mimee, Mark; Lu, Timothy K.

J Allergy Clin Immunol ; 144(3): 645-647, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31376406

5.

Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements.

Hayashi, Naoki; Lai, Yong; Fuerte-Stone, Jay; Mimee, Mark; Lu, Timothy K.

Nat Commun ; 15(1): 2096, 2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-38453913

6.

Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA.

Thanabalasuriar, Ajitha; Bergeron, Julien; Gillingham, Akira; Mimee, Mark; Thomassin, Jenny-Lee; Strynadka, Nathalie; Kim, Jinoh; Gruenheid, Samantha.

Cell Microbiol ; 14(8): 1206-18, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22432415

7.

Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.

Kemter, Andrea M; Patry, Robert T; Arnold, Jack; Hesser, Lauren A; Campbell, Evelyn; Ionescu, Edward; Mimee, Mark; Wang, Shan; Nagler, Cathryn R.

Cell Rep ; 42(10): 113153, 2023 10 31.

Artigo em Inglês | MEDLINE | ID: mdl-37742185

8.

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut.

Fogarty, Emily C; Schechter, Matthew S; Lolans, Karen; Sheahan, Madeline L; Veseli, Iva; Moore, Ryan; Kiefl, Evan; Moody, Thomas; Rice, Phoebe A; Yu, Michael K; Mimee, Mark; Chang, Eugene B; Mclellan, Sandra L; Willis, Amy D; Comstock, Laurie E; Eren, A Murat.

bioRxiv ; 2023 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-36993556

9.

Host happy hour: Phage cocktail targets IBD-associated microbes.

Fuerte-Stone, Jay; Mimee, Mark.

Cell Host Microbe ; 30(10): 1352-1353, 2022 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-36228584

10.

Proceedings from the 3rd International Conference on Microbiome Engineering.

McClure, Sandra; Enam, Fatima; Arnold, Jack; Mimee, Mark.

Biotechnol Prog ; 38(3): e3241, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35092364

11.

A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.

Bousbaine, Djenet; Fisch, Laura I; London, Mariya; Bhagchandani, Preksha; Rezende de Castro, Tiago B; Mimee, Mark; Olesen, Scott; Reis, Bernardo S; VanInsberghe, David; Bortolatto, Juliana; Poyet, Mathilde; Cheloha, Ross W; Sidney, John; Ling, Jingjing; Gupta, Aaron; Lu, Timothy K; Sette, Alessandro; Alm, Eric J; Moon, James J; Victora, Gabriel D; Mucida, Daniel; Ploegh, Hidde L; Bilate, Angelina M.

Science ; 377(6606): 660-666, 2022 08 05.

Artigo em Inglês | MEDLINE | ID: mdl-35926021

12.

The bacterial virulence factor NleA is required for the disruption of intestinal tight junctions by enteropathogenic Escherichia coli.

Thanabalasuriar, Ajitha; Koutsouris, Athanasia; Weflen, Andrew; Mimee, Mark; Hecht, Gail; Gruenheid, Samantha.

Cell Microbiol ; 12(1): 31-41, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19712078

13.

An ingestible bacterial-electronic system to monitor gastrointestinal health.

Mimee, Mark; Nadeau, Phillip; Hayward, Alison; Carim, Sean; Flanagan, Sarah; Jerger, Logan; Collins, Joy; McDonnell, Shane; Swartwout, Richard; Citorik, Robert J; Bulovic, Vladimir; Langer, Robert; Traverso, Giovanni; Chandrakasan, Anantha P; Lu, Timothy K.

Science ; 360(6391): 915-918, 2018 05 25.

Artigo em Inglês | MEDLINE | ID: mdl-29798884

14.

Engineered yeast tune down gut inflammation.

Mimee, Mark; Nagler, Cathryn R.

Nat Med ; 27(7): 1150-1151, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-34183835

15.

Microbiome therapeutics - Advances and challenges.

Mimee, Mark; Citorik, Robert J; Lu, Timothy K.

Adv Drug Deliv Rev ; 105(Pt A): 44-54, 2016 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-27158095

16.

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.

Mimee, Mark; Tucker, Alex C; Voigt, Christopher A; Lu, Timothy K.

Cell Syst ; 1(1): 62-71, 2015 Jul 29.

Artigo em Inglês | MEDLINE | ID: mdl-26918244

17.

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.

Citorik, Robert J; Mimee, Mark; Lu, Timothy K.

Nat Biotechnol ; 32(11): 1141-5, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25240928

18.

Bacteriophage-based synthetic biology for the study of infectious diseases.

Citorik, Robert J; Mimee, Mark; Lu, Timothy K.

Curr Opin Microbiol ; 19: 59-69, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24997401

19.

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.

Mimee, Mark; Tucker, Alex C; Voigt, Christopher A; Lu, Timothy K.

Cell Syst ; 2(3): 214, 2016 Mar 23.

Artigo em Inglês | MEDLINE | ID: mdl-27135367

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A cryptic plasmid is among the most numerous genetic elements in the human gut.

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis.

Genetic Engineering of Resident Bacteria in the Gut Microbiome.

Cell-based biosensors for immunology, inflammation, and allergy.

Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements.

Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA.

Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut.

Host happy hour: Phage cocktail targets IBD-associated microbes.

Proceedings from the 3rd International Conference on Microbiome Engineering.

A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.

The bacterial virulence factor NleA is required for the disruption of intestinal tight junctions by enteropathogenic Escherichia coli.

An ingestible bacterial-electronic system to monitor gastrointestinal health.

Engineered yeast tune down gut inflammation.

Microbiome therapeutics - Advances and challenges.

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.

Bacteriophage-based synthetic biology for the study of infectious diseases.

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.