Detalhe da pesquisa
1.
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
BMC Biol
; 20(1): 182, 2022 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35986286
2.
Knowledge, practice, and economic impacts of COVID-19 on small-scale coastal fishing communities in Bangladesh: Policy recommendations for improved livelihoods.
Mar Policy
; 131: 104647, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34511705
3.
A Chemical Probe for the ATAD2 Bromodomain.
Angew Chem Int Ed Engl
; 55(38): 11382-6, 2016 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27530368
4.
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
ACS Med Chem Lett
; 14(9): 1231-1236, 2023 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37736196
5.
A Randomized Feasibility Trial of Stereotactic Prostate Radiation Therapy With or Without Elective Nodal Irradiation in High-Risk Localized Prostate Cancer (SPORT Trial).
Int J Radiat Oncol Biol Phys
; 117(3): 594-609, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893820
6.
Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
J Med Chem
; 66(23): 15728-15749, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967462
7.
Toxicity and Efficacy of Concurrent Androgen Deprivation Therapy, Pelvic Radiotherapy, and Radium-223 in Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer.
Clin Cancer Res
; 27(16): 4549-4556, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34187853
8.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34232650
9.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662213
10.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255512
11.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem
; 64(16): 12200-12227, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387088
12.
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
J Med Chem
; 63(10): 5212-5241, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321240
13.
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.
J Med Chem
; 63(17): 9070-9092, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32691591
14.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
ACS Med Chem Lett
; 11(8): 1581-1587, 2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832027
15.
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
J Med Chem
; 63(17): 9020-9044, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787145
16.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.
J Med Chem
; 63(17): 9093-9126, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32702236
17.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904959
18.
A pilot study of patient reported outcomes evaluating treatment related symptoms and quality of life for men receiving high dose rate brachytherapy combined with hypo-fractionated radiotherapy or hypo-fractionated radiotherapy alone for the treatment of localised prostate cancer.
Tech Innov Patient Support Radiat Oncol
; 9: 18-25, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32095591
19.
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.
J Med Chem
; 62(16): 7506-7525, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31398032
20.
Analysis of prostate-specific antigen bounce after I(125) permanent seed implant for localised prostate cancer.
Radiother Oncol
; 88(1): 102-7, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18453022