1.
J Am Chem Soc
; 142(4): 1692-1697, 2020 01 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31939289
RESUMO
In this paper, we report efficient cyanation of various peptides containing the α-bromocarbonyl moiety using a Cu-catalyzed radical-based methodology employing zinc cyanide as the cyanide source. Mechanistic studies revealed that in situ formed CuCN was a key intermediate during the catalytic cycle. Our method could be useful for the synthesis of modified peptides containing quaternary carbons.