Dynamics of postnatal depressive symptoms in early parenthood.

BACKGROUND: New mothers and fathers are at risk of developing postnatal depressive problems. To understand how postnatal depressive symptoms unfold over time, analyses at the within-person level are necessary. Inspecting postnatal depressive problems at the symptom level provides a novel perspective, ultimately offering insight into which symptoms contribute to the elevation of other symptoms over time. METHODS: Panel graphical vector-autoregression (GVAR) models were applied to analyze the within-person temporal and contemporaneous relations between depressive symptoms across the postnatal period in new mothers and fathers (at T1; Nmothers = 869, Nfathers = 579). Depressive symptoms were assessed at 6-, 12-, and 18-months postpartum, using the Edinburgh Postnatal Depression Scale. RESULTS: The results revealed that for mothers, sadness was a key symptom predicting symptom increases in multiple other depressive symptoms and itself (autoregressive effect) over time. Furthermore, anxiousness and feeling scared predicted each other across the postnatal period in mothers. For fathers, the most central predicting symptom in the overall network of symptoms was being anxious, while self-blame and being overwhelmed had strong self-maintaining roles in the fathers' symptomatology, indicating that these could be key features in fathers experiencing postnatal depressive problems. The pattern of symptoms that mothers and fathers experienced within the same time window (contemporaneous associations), shared many of the same characteristics compared to the temporal structure. CONCLUSIONS: This study suggests that across the postnatal period, from 6- to 18-months postpartum, depressive symptoms in mothers and fathers contribute differently to the pattern of depressive problems, highlighting sadness as a key feature in maternal symptomatology and anxiousness components in paternal symptomatology.

Parenting the parent without losing sight of the child. A qualitative study of therapists' experiences with intergenerational adversities in perinatal psychotherapy.

The complex work of addressing intergenerational adversities, like violence, abuse, and neglect through perinatal psychotherapy, is understudied. Especially noticeable is the paucity of studies giving voice to the therapists. This study explored therapeutic processes through the perspectives of seven Norwegian therapists. A qualitative approach was chosen with individual interviews and a follow-up focus group. Data were analyzed using reflexive thematic analysis. We identified one overarching theme: To maintain a reflective therapeutic capacity, and two main themes with associated subthemes: 1) Alliance work when a caring system comes to therapy to fight generations of adversities and 2) The complex therapeutic work of addressing generational adversities in perinatal psychotherapy. Findings from the present study indicate that maintaining a reflective stance is essential yet challenging when addressing intergenerational adversities, requiring a holding environment for the therapists. The primary vehicle of change was perceived as a safe enough therapeutic alliance to explore new ways of being together, contrasting earlier experiences. A key question raised was how to give caregivers enough time to trust the therapist without compromising the safety and development of the child. The essence of the therapeutic work was to reduce risk factors and increase protective factors through multiple ports of entry.

El complejo trabajo de abordar el tema de adversidades intergeneracionales, como violencia, abuso y negligencia a través de la sicoterapia perinatal, no se ha estudiado lo suficiente. Especialmente perceptible es la escasez de estudios que les den voz a los terapeutas. Este estudio exploró los procesos terapéuticos a través de perspectivas de siete terapeutas noruegos. Se escogió un acercamiento cualitativo con entrevistas individuales y un grupo de enfoque como seguimiento. Se analizaron los datos usando un análisis temático reflexivo. Identificamos un tema global: Mantener una capacidad terapéutica reflexiva, así como dos temas principales con subtemas asociados: 1) Trabajo en alianza cuando un sistema de cuidados llega a la terapia, para combatir generaciones de adversidades y 2) El complejo trabajo terapéutico de abordar el tema de adversidades generacionales en la sicoterapia perinatal. Los resultados del presente estudio indicaron que mantener una postura de reflexión es esencial, aunque desafiante, cuando se aborda el tema de adversidades generacionales, lo cual requiere un entorno o espacio favorable para los terapeutas. La percepción es que el vehículo primario para el cambio es una suficientemente segura alianza terapéutica para explorar nuevas maneras de vivir juntos, contrastando las experiencias anteriores. Una pregunta clave que se planteó fue cómo darles a los cuidadores suficiente tiempo para que le tengan confianza al terapeuta sin comprometer la seguridad y el desarrollo del niño. La esencia del trabajo terapéutico fue reducir los factores de riesgo e incrementar los factores de protección por medio de múltiples puertas de entrada.

Le travail complexe qui consiste à s'attaquer aux adversités intergénérationnelles comme la violence, la maltraitance et la négligence au travers de la psychothérapie périnatale est sous-étudié. On constate surtout la rareté d'études donnant la parole aux thérapeutes. Cette étude a exploré les processus thérapeutiques au travers des perspectives de sept thérapeutes norvégiens. Une approche qualitative a été choisie avec des entretiens individuels et un groupe d'étude de suivi. Des données ont été analysées en utilisant une analyse réflective thématique. Nous avons identifié un thème général: maintenir une capacité thérapeutique réflective et deux thèmes principaux avec des sous-thèmes liés: 1) le travail d'alliance quand un système attentif en arrive à la thérapie pour contrecarrer des générations d'adversités et 2) le travail thérapeutique complexe qui consiste à s'attaquer aux adversités intergénérationnelles en psychothérapie périnatale. Les résultats de cette étude ont indiqué que le maintien d'une position de réflexion est essentiel mais pose également un défi lorsqu'on on s'attaque aux adversités intergénérationnelles, exigeant un environnement thérapeutique soutenant pour les thérapeutes. Le principal véhicule de changement a été perçu comme une alliance thérapeutique étant assez sûre pour l'exploration de nouvelles façons d'être ensemble, en contraste avec des expériences précédentes. Une question clé qui a été soulevée était de comment donner aux personnes prenant soin des enfants assez de temps pour avoir confiance au thérapeute sans compromettre la sécurité et le développement de l'enfant. L'essence du travail thérapeutique a consisté à réduire les facteurs de risque et à accroître les facteurs protecteurs au travers de plusieurs ports d'entrée.

Dyadic parent-infant interaction patterns at 12 months: Exploring dyadic parent-infant gender compositions.

This study investigates differences in dyadic mother-infant and father-infant interaction patterns at infant age 12 months, and the relation between different parent-infant gender compositions and the dyadic interaction. Data were drawn from a large-scale, population-based Norwegian community sample comprising 671 mother-infant and 337 father-infant interactions. The Early Relational Health Screen (ERHS), a screening method for observing dyadic parent-infant interactions, was used to assess the parent-infant interactions. Scores on the ERHS were employed to investigate dyadic differences in the overall interaction scores, and dyadic interaction on seven sub-dimensions between mother-infant and father-infant pairs. The relation between different parent-infant gender compositions and the dyadic interaction scores was also examined. As expected in a normative sample, most parent-infant interactions received scores in the upper rating levels. Differences between mother-infant and father-infant patterns were generally small, but mother-infant dyads tended to obtain slightly higher scores. The mother-infant dyads received higher scores on the dimensions of engagement and enjoyment, but no other significant differences between the parent-infant pairs were found for the remaining dimensions. We did not find evidence for a moderation effect of child gender. However, parent-daughter dyads received somewhat higher scores than the parent-son dyads.

Este estudio investiga las diferencias en los patrones de interacción de las díadas madre-infante y padre-infante a los 12 meses de edad del infante, y la relación entre las diferentes composiciones de género de progenitor-infante y la interacción diádica. Los datos se obtuvieron de un grupo muestra a gran escala con base en la población en una comunidad noruega y el mismo comprendía 671 interacciones madre-infante y 337 padre-infante. La Temprana Detección de Salud de la Relación (ERHS), un método de examinación para observar las interacciones progenitor-infante, se usó para evaluar las interacciones progenitor-infante. Los puntajes de ERHS se emplearon para investigar las diferencias diádicas dentro de los puntajes de interacción generales, y las interacciones diádicas acerca de siete sub-dimensiones entre los pares de madre-infante y padre-infante. También se examinó la relación entre las diferentes composiciones de género progenitor-infante y la interacción diádica. Como se esperaba en un grupo muestra normativo, la mayoría de las interacciones progenitor-infante recibió puntajes en los niveles superiores de la evaluación. Las diferencias entre los patrones madre-infante y padre-infante fueron generalmente pequeñas, pero las díadas madre-infante tendieron a recibir puntajes un poquito más altos. Las díadas madre-infante recibieron más altos puntajes en las dimensiones de participación y disfrute, pero no se encontraron otras diferencias significativas entre los pares progenitor-infante en el resto de las dimensiones. No encontramos evidencia de un efecto de moderación del género del infante. Sin embargo, las díadas padre-hija recibieron hasta cierto punto puntaje más altos que las díadas padre-hijo.

Cette étude porte sur les différences dans les patterns d'interaction dyadique mère-nourrisson et père-nourrisson à l'âge de 12 mois pour le bébé, et la relation entre les différentes compositions de genre parent-bébés et l'interaction dyadique. Les données ont été extraites d'un échantillon communautaire norvégien de grande taille, basé sur la population, comprenant 671 interactions mère-nourrisson et 337 interactions père-nourrisson. Le Dépistage Précoce de Santé Relationnelle (ERHS), une méthode de dépistage pour l'observation des interactions dyadiques parent-bébé, a été utilisé afin d'évaluer les interactions parent-bébé. Les scores au ERHS ont été employés pour rechercher les différences entre les scores d'interaction généraux et l'interaction dyadique concernant sept sous-dimensions entre les paires mère-bébé et père-bébé. La relation entre les différentes compositions de genre parent-bébé et les scores d'interaction dyadique a également été examinée. Comme prévu dans un échantillon normatif la plupart des interactions parent-bébé ont reçu des scores dans les niveaux les plus hauts. Les différences entre les patterns mère-bébé et père-bébé étaient généralement petites mais les dyades mère-bébé ont eu tendance à obtenir des scores un peu plus élevés. Les dyades mère-bébé ont reçu de meilleurs scores quant aux dimensions d'engagement et de plaisir, mais aucune autre différence importante n'a été trouvée entre les paires parent-bébé pour les autres dimensions. Nous n'avons pas trouvé de preuves d'un effet de modération pour le genre de l'enfant. Cependant les dyades parent-fille ont reçu des scores un peu plus élevés que les dyades parent-fils.

The context and development of the early relational health screen.

Early relational experiences are key drivers for developing social emotional capacities, educational achievement, mental health, physical health, and overall wellbeing. The child health sectors are committed to promotion, prevention, and early intervention that optimize children's health and development, often employing evidence-based screening as foundational practices. Despite a variety of validated parent-infant observational assessment tools, few are practical within busy practice settings, acceptable with all racial and ethnic groups and ready for universal adoption. In response to this need, a team of clinicians, early childhood educators, researchers and infant mental health specialists collaborated to develop and test a novel video-based, dyadic relational screening and monitoring tool, the Early Relational Health Screen (ERHS). This tool uniquely focuses on the early parent-child relationship (6-24 months), within the construct of early relational health (ERH). Initial testing demonstrated that the ERHS is a valid, reliable, feasible, and useful screening and monitoring tool for clinical applications. The ERHS was further developed within a population-based, prospective research study and adapted with brief video feedback for parents in the home visiting and child health sectors. The ERHS and its adaptations appear to advance ERH and equity within the transforming child health and public health care systems of today.

Las tempranas experiencias de relaciones afectivas son clave para desarrollar las capacidades socioemocionales, para los logros educativos, la salud mental, la salud física y el bienestar en general. Los sectores de salud infantil están comprometidos a promover, prevenir e intervenir a tiempo para que la salud de los niños y su desarrollo sean óptimos, a menudo empleando examinaciones basadas en la evidencia como prácticas fundamentales. A pesar de la variedad de válidas herramientas para la evaluación con base en la observación progenitor-infante, pocas son prácticas dentro del ocupado campo de la práctica, aceptables con todos los grupos raciales y étnicos, y pocas están listas para ser adoptadas en forma generalizada. Como respuesta a esta necesidad, un equipo formado por clínicos profesionales, educadores de la temprana niñez, investigadores y especialistas de la salud mental infantil colaboraron para desarrollar y probar una herramienta novedosa basada en videos, con el fin de examinar y darle seguimiento a la relación de la díada, el Examen del Bienestar de la Temprana Relación (ERHS). Esta herramienta de manera única se enfoca en la temprana relación progenitor-niño (6-24 meses), dentro del marco del temprano bienestar de la relación. La examinación inicial demostró que ERHS es una herramienta de examinación y seguimiento válida, confiable, posible y útil para la aplicación clínica. Entonces ERHS se desarrolló dentro de un estudio de investigación de probabilidades, con base en la población, y se adaptó con breves respuestas en video para progenitores en los sectores de visitas a casa y salud infantil. ERHS y sus adaptaciones parecen avanzar el temprano bienestar de la relación (ERH) y la equidad dentro de los sistemas de salud infantil y cuidado de salud pública en transformación hoy día.

Les expériences relationnelles sont des moteurs essentiels pour le développement des capacités socio-émotionnelles, la réussite scolaire, la santé mentale, la santé physique et le bien-être général. Les secteurs de la santé de l'enfant sont dédiés à la promotion, à la prévention et à l'intervention précoce qui optimisent la santé des enfants et leur développement, en employant souvent des dépistages fondés sur des données probantes en tant que pratiques fondamentales. En dépit d'une variété d'outils d'évaluation observationnelle parent-bébé validés, peu de ces outils sont pratique au sein d'un cabinet de pratique très occupé et peu sont acceptables pour tous groupes raciaux et éthiques ainsi que prêts pour une adoption universelle. Pour répondre à ce besoin une équipe de cliniciens, d'éducateurs de la petite enfance, de chercheurs et de spécialistes de la santé mentale du nourrisson ont collaboré afin de développer et de tester un outil innovateur et basé sur la vidéo de dépistage relationnel dyadique et de suivi, le Dépistage de Santé Relationnelle Précoce (en anglais Early Relational Health Screen dont nous gardons l'abréviation ici, ERHS). Cet outil se concentre uniquement sur la relation précoce parent-enfant (6-24 mois), dans le cadre de la construction de la santé relationnelle précoce. Les essais ont montré que l'ERHS est un outil de dépistage et de suivi valide, fiable, réalisable et utile pour les applications cliniques. L'ERHS a été plus profondément développé au sein d'une étude de recherches de prospection, basées sur certaines populations, et adapté avec de brefs commentaires vidéo pour les parents dans les secteurs des visites à domicile et de la santé de l'enfant. L'ERHS et ses adaptations semblent faire progresser la Santé Relationnelle Précoce et l'équité au sein des transformation de la santé de l'enfant et des systèmes de santé publique d'aujourd'hui.

Iodine status during pregnancy and at 6 weeks, 6, 12 and 18 months post-partum.

Iodine deficiency during pregnancy and in the post-partum period may lead to impaired child development. Our aim is to describe iodine status longitudinally in women from pregnancy until 18 months post-partum. Furthermore, we explore whether iodine status is associated with dietary intake, iodine-containing supplement use and breastfeeding status from pregnancy until 18 months post-partum. We also assess the correlation between maternal iodine status 18 months post-partum and child iodine status at 18 months of age. Iodine status was measured by urinary iodine concentration (UIC) during pregnancy (n = 1,004), 6 weeks post-partum (n = 915), 6 months post-partum (n = 849), 12 months post-partum (n = 733) and 18 months post-partum (n = 714). The toddlers' UIC was assessed at 18 months of age (n = 416). Demographic variables and dietary data (food frequency questionnaire) were collected during pregnancy, and dietary data and breastfeeding practices were collected at all time points post-partum. We found that iodine status was insufficient in both pregnant and post-partum women. The UIC was at its lowermost 6 weeks post-partum and gradually improved with increasing time post-partum. Intake of milk and use of iodine-containing supplements significantly increased the odds of having a UIC above 100 µg/L. Neither the mothers' UIC, vegetarian practice, nor exclusion of milk and dairy products were associated with the toddlers UIC 18 months post-partum. Women who exclude milk and dairy products from their diets and/or do not use iodine-containing supplements may be at risk of iodine deficiency. The women possibly also have an increased risk of thyroid dysfunction and for conceiving children with nonoptimal developmental status.

Newborn Behavioral Observation, maternal stress, depressive symptoms and the mother-infant relationship: results from the Northern Babies Longitudinal Study (NorBaby).

BACKGROUND: Families can experience the postpartum period as overwhelming and many report a special need for support. The Newborn Behavioral Observation (NBO) aims to promote a positive parent-infant relationship by sensitising parents to the infant's signals. This article evaluates the NBO as a universal preventive intervention within the regular well-baby clinic service on measures of maternal depressive symptoms, parental stress, the mother-infant relationship and satisfaction/benefit of the postpartum follow-up. METHODS: This investigation is part of a larger longitudinal study comprising 220 women and 130 of their partners recruited between 2015 and 2017. The study had a non-randomised cluster-controlled design with 6 measurement points. This article is based on a sample of 196 women using data from T1 (gestational weeks 13-39), T4 (5-15 weeks postpartum) and T5 (3-9 months postpartum). Participants were allocated to a group receiving the NBO (n = 82) and a care as usual comparison group (n = 114). We measured maternal depressive symptoms and parental stress using the Edinburgh Postnatal Depression Scale (EPDS) and the Parenting Stress Index (PSI). The mother-infant relationship was assessed with the Parental Reflective Functioning Questionnaire (PRFQ), the Maternal Postnatal Attachment Scale (MPAS) and the Maternal Confidence Questionnaire (MCQ). Participants also answered questions about satisfaction/benefit of the postpartum follow-up. RESULTS: A Mann-Whitney U test indicated that participants in the NBO-group learned significantly more than the comparison group from the follow-up about the baby's signals in relation to sleep/sleep patterns, social interaction and crying/fuzziness. Multivariate analyses of covariance (MANCOVA) and repeated measures ANCOVA found no significant differences between the groups for the mother-infant relationship domain and few differences in depressive symptoms and parental stress. The repeated measures ANCOVA found that participants in the NBO-group scored slightly higher on parental stress, although the difference was small. CONCLUSIONS: The results indicate that the NBO-group learned more than the comparison group about reading their child's signals in important everyday situations. However, the benefits of the NBO were limited for depressive symptoms, parental stress and self-reported mother-infant relationship. The study sample was generally well-functioning, and the results indicate that the benefits of the NBO may be limited within a well-functioning sample. TRIAL REGISTRATION: ClinicalTrials, NCT02538497, Registered 2 September 2015.

Antecedents of fathers' perception of child behavior at child age 12 months.

This study investigates whether fathers' adverse childhood experiences (ACE) and attachment style reported during pregnancy predict fathers' perception of child behavior assessed 12 months postpartum, expressed by the Parenting Stress Index (PSI), Child Domain. Prospective fathers (N = 835) were recruited to "The Little in Norway (LiN) study" (Moe & Smith) at nine well-baby clinics in Norway, with data collection composed of five time points during pregnancy and two time points postpartum (6 and 12 months). The main analyses included linear regression, path-analysis modeling, and intraclass correlation based on mixed effects modeling. First, linear regression analyses showed that neither fathers' ACE nor attachment style significantly predicted perceived child behavior postpartum directly. Furthermore, path analyses showed that ACE and less secure attachment style (especially avoidant attachment) measured early in pregnancy strongly predicted negatively perceived child behavior, mediated by fathers' mental health symptoms during pregnancy and partner disharmony postpartum. Second, intraclass correlation analyses showed that fathers' perceived child behavior showed substantial stability between 6 and 12 months postpartum. Family interventions beginning in pregnancy may be most beneficial given that fathers' early experiences and perceptions of attachment in pregnancy were associated with later partner disharmony and stress.

Este estudio investiga si las experiencias adversas de los papás en su niñez y el estilo de afectividad reportado durante el embarazo predicen las percepciones de los papás sobre el comportamiento del niño según evaluación a los 12 meses después del parto, expresada por el Índice de Estrés de Crianza (PSI), Ámbito del Niño. Los papás con la posibilidad de participar (N = 835) fueron reclutados para el "estudio El Pequeño en Noruega (LiN)" (Moe y Smith, 2010) en nueve clínicas de revisión pediátrica en Noruega, con un proceso de recoger información compuesto de cinco momentos temporales durante el embarazo y dos momentos después del parto (6 y 12 meses). Los análisis principales incluyeron regresión lineal, diseños de análisis de trayectoria y correlación intraclase basados en diseños de efectos mixtos. Primero, los análisis de regresión lineal mostraron que ni las experiencias adversas de los papás en su niñez ni el estilo de afectividad predijeron significativamente la percepción del comportamiento del niño posterior al parto directamente. Es más, los análisis de trayectoria mostraron que las experiencias adversas en la niñez y un menos seguro estilo de afectividad (especialmente la afectividad esquiva) tal como fueron medidos a principios del embarazo predijeron fuertemente la percepción negativa del comportamiento del niño, todo lo cual fue mediado por los síntomas de salud mental de los papás durante el embarazo y la desarmonía de la pareja después del parto. Segundo, los análisis de correlación intraclase mostraron que la percepción que tenían los papás acerca del comportamiento del niño mostraba una estabilidad sustancial entre los 6 y 12 meses después del parto. Las intervenciones familiares que comienzan durante el embarazo pudieran ser más beneficiosas dado que las tempranas experiencias de los papás y sus percepciones de la afectividad durante el embarazo se asociaron con la posterior desarmonía y estrés de la pareja.

Cette étude s'est interrogée si les expériences adverses de l'enfance des pères et le style d'attachement rapporté durant la grossesse prédisait la perception des pères du comportement de l'enfant évalué 12 mois après la naissance, exprimé par l'Index de Stress de Parentage (en anglais PSI), le Domaine de l'Enfant. Des pères potentiels (N = 835) ont été recruté pour l'étude norvégienne "The Little in Norway (LiN) study" (Moe & Smith, 2010) dans neuf cliniques de bien-être du bébé en Norvège, avec un recueil de données comprenant cinq points de recueil durant la grossesse et deux après la grossesse (6 et 12 mois). Les analyses principales ont inclus une régression linéaire, une modélisation de l'analyse des trajectoires et une corrélation intraclasse basée sur une modélisation des effets mixtes. Tout d'abord, les analyses de régression linéaires ont montré que ni les expériences adverses vécues par les pères durant leur enfance ni le style d'attachement ne prédisait directement de façon importante le comportement de l'enfant perçu après la naissance. De plus les analyses de parcours ont montré que les expériences adverses vécues pendant l'enfance et le style d'attachement moins sécure (particulièrement l'attachement évitant) mesurés tôt dans la grossesse prédisaient fortement le comportement de l'enfant perçu négativement, médié par les symptômes de santé mentale des pères durant la grossesse et la discorde entre partenaires après la naissance. Deuxièmement les analyses de corrélation intraclasse ont montré que le comportement de l'enfant perçu des pères faisait preuve de stabilité substantielle entre 6 et 12 mois après la naissance. Des interventions sur la famille commençant durant la grossesse peuvent être plus bénéfiques au vu des expériences vécues des pères et les perceptions de l'attachement durant la grossesse étaient liées à la discorde ultérieure entre les partenaires et au stress.

Mothers with and without bipolar disorder and their infants: group differences in mother-infant interaction patterns at three months postpartum.

BACKGROUND: Women with bipolar disorder (BD) have a high risk of illness relapse postpartum. The risk coincides with the period when mother-infant interactions are evolving. We compared mother-infant interactions in dyads where the mothers have BD with dyads where the mothers have no mental disorder. The association between concurrent affective symptoms of BD mothers and interaction quality was investigated. METHODS: Twenty-six women with BD and 30 comparison women with infants were included. The Parent-Child Early Relational Assessment (PCERA) was used to assess maternal behaviour, infant behaviour and dyadic coordination in interactions at 3 months postpartum. The Inventory of Depressive Symptomatology and Young Mania Rating Scale were used to assess affective symptoms of BD mothers at the time of interaction. RESULTS: There were significant group differences with medium to large effect sizes (0.73-1.32) on five of six subscales within the three interactional domains. Most interactional concerns were identified in dyadic coordination. No significant associations were found between maternal symptom load and interaction quality within the BD sample. Forty-six percent of the BD mothers experienced a mood episode within 0-3 months postpartum. CONCLUSIONS: The present study identified challenges for mothers with BD and their infants in "finding" each other in interaction at 3 months postpartum. If sustained, this interaction pattern may have a long-term impact on children's development. We suggest interventions specifically focusing on sensitising and supporting mothers to read infants' cues on a micro-level. This may help them to respond contingently and improve dyadic coordination and synchronicity.

Prenatal maternal depressive symptoms and infant DNA methylation: a longitudinal epigenome-wide study.

Background: Prenatal maternal stress increases the risk of offspring developmental and psychological difficulties. The biological mechanisms behind these associations are mostly unknown. One explanation suggests that exposure of the fetus to maternal stress may influence DNA methylation. However, this hypothesis is largely based on animal studies, and human studies of candidate genes from single timepoints. Aim: The aim of this study was to investigate if prenatal maternal stress, in the form of maternal depressive symptoms, was associated with variation in genome-wide DNA methylation at two timepoints. Methods: One-hundred and eighty-four mother-child dyads were selected from a population of pregnant women in the Little-in-Norway study. The Edinburgh Postnatal Depression Scale (EPDS) measured maternal depressive symptoms. It was completed by the pregnant mothers between weeks 17 and 32 of gestation. DNA was obtained from infant saliva cells at two timepoints (age 6 weeks and 12 months). DNA methylation was measured in 274 samples from 6 weeks (n = 146) and 12 months (n = 128) using the Illumina Infinium HumanMethylation 450 BeadChip. Linear regression analyses of prenatal maternal depressive symptoms and infant methylation were performed at 6 weeks and 12 months separately, and for both timepoints together using a mixed model. Results: The analyses revealed no significant genome-wide association between maternal depressive symptoms and infant DNA methylation in the separate analyses and for both timepoints together. Conclusions: This sample of pregnant women and their infants living in Norway did not reveal associations between maternal depressive symptoms and infant DNA methylation.

Quality of social interaction in foster dyads at child age 2 and 3 years.

The main aim of this study was to investigate the quality of social interaction between 60 foster parents and their foster children compared to a group of 55 non-foster families at 2 (T1) and again at 3 (T2) years of age. Video observations were used to investigate child-parent interaction at both time-points. "This is My Baby" interview was administered to investigate foster parents' commitment at T1. The main results revealed significant group differences at T1 on all child-parent social interaction measures, although not at T2. Further, a significant group by time interaction was identified for parental sensitivity, revealing a positive development over time in the foster group. Finally, a significant positive relation was found between commitment at T1 and parental sensitivity. The results convey an optimistic view of the possibilities for foster dyads to develop positive patterns of social interaction over time.

Early postpartum discharge: maternal depression, breastfeeding habits and different follow-up strategies.

BACKGROUND: In most maternity wards in Norway, early discharge (<48 hour) is the norm. To monitor newborns' and women's health during the first week after delivery, most maternity wards offer early check-ups, where families return to the hospital (standard care). However, a few municipalities offer home visits by midwives (domiciliary care) to ensure seamless services for the family. AIM: The primary aim of this study was to explore whether different follow-up strategies were differently associated with maternal depression and breastfeeding habits, 6 weeks and 6 months postpartum. The secondary aim was to investigate whether families at risk of postpartum depression were included in the home visiting programme in the municipality that offered both follow-up strategies. METHOD: This study draws on data from the 'Little in Norway' (LIN) study, which followed families from pregnancy until the child was 18 months. This study used data from two different well-baby clinics in two municipalities, where one offered standard care (n = 95) and the other domiciliary (n = 64) and standard care (n = 17). The Edinburg Postnatal Depression Scale (EPDS) was used to measure maternal depression. Breastfeeding habits were measured using a self-report questionnaire. The Life Stress subscale of the Parenting Stress Index (PSI) was used to identify women at risk of postpartum depression. RESULTS: There were no differences in maternal depressive symptoms or breastfeeding habits at neither 6 weeks nor 6 months postpartum between women who received standard or domiciliary care in the two municipalities. Within the municipality that offered both follow-up strategies, a higher number of women scoring high on prenatal life stress were included in domiciliary - compared to standard care. CONCLUSION: Differential follow-up strategies in the first week after birth did not impact on maternal depression or breastfeeding habits. However, domiciliary care seems to be regarded as supportive and nonstigmatising for women at risk of postpartum depression.

DOES FATHERS' PRENATAL MENTAL HEALTH BEAR A RELATIONSHIP TO PARENTING STRESS AT 6 MONTHS?

This study aimed to explore fathers' mental health and retrospectively reported adverse childhood experiences during pregnancy, as well as various pathways predicting self-reported stress at 6 months' postpartum as assessed by the Parenting Stress Index (PSI; R.R. Abidin, ). A total of 835 fathers contributed data to the study. Data collection comprised five time points during pregnancy and one at 6 months' postpartum. The main analyses were performed using linear regression and path analyses. First, linear regression analyses showed that paternal anxiety symptoms during pregnancy predicted stress scores in the PSI child domain at 6 months (coefficient = 0.36). Second, path analyses showed that depressive symptoms during pregnancy predicted parenting stress in the child domain, mediated by spousal disharmony at 6 months' postpartum (coefficient = 0.77). Third, adverse childhood experiences scores predicted parenting stress in the child domain by two different pathways: one mediated by anxiety symptoms in pregnancy (coefficient = 0.29) and the other by depressive symptoms in pregnancy and experienced spousal disharmony at 6 months' postpartum (coefficient = 0.77). The findings suggest that fathers' symptoms of anxiety and depression during pregnancy as well as adverse childhood experiences predict paternal stress and a negative perception of their children's behavior at 6 months' postpartum.

TEMPERAMENTAL ADAPTABILITY, PERSISTENCE, AND REGULARITY: PARENTAL RATINGS OF NORWEGIAN INFANTS AGED 6 TO 12 MONTHS, WITH SOME IMPLICATIONS FOR PREVENTIVE PRACTICE.

There is a need for standardized measures of infant temperament to strengthen current practices in prevention and early intervention. The present study provides Norwegian data on the Cameron-Rice Infant Temperament Questionnaire (CRITQ; J.R. Cameron & D.C. Rice, 1986a), which comprises 46 items and is used within a U.S. health maintenance organization. The CRITQ was filled out by mothers and fathers at 6 and again at 12 months as part of a longitudinal study of mental health during the first years of life (the "Little in Norway" study, N = 1,041 families enrolled; V. Moe & L. Smith, 2010). Results showed that internal consistencies were comparable with U.S. DATA: The temperament dimensions of persistence, adaptability, and regularity had acceptable or close-to-acceptable reliabilities in the U.S. study as well as in this study, and also were unifactorial in confirmatory factor analysis. These dimensions are the focus in this article. Findings concerning parents' differential ratings of their infants on the three dimensions are reported, as is the stability of parents' ratings of temperament from 6 to 12 months. In addition, results on the relation between temperament and parenting stress are presented. The study suggests that temperamental adaptability, persistence, and regularity may be relevant when assessing infant behavior, and may be applied in systematic prevention trials for families with infants. The inclusion of concepts related to individual differences in response tendencies and regulatory efforts may broaden the understanding of parent-infant transactions, and thus enrich prevention and sensitizing interventions with the aim of assisting infants' development.

COGNITIVE AND SOCIOEMOTIONAL FUNCTIONING AT 4½ YEARS IN CHILDREN BORN TO MOTHERS WHO HAVE RECEIVED TREATMENT FOR SUBSTANCE-ABUSE PROBLEMS WHILE PREGNANT.

Cognitive and socioemotional functioning at 4½ years of age were examined in children born to mothers with substance-abuse problems (n = 22) recruited from residential treatment institutions while pregnant, and then compared to children born to mothers with mental health problems (n = 18) and children from a low-risk group (n = 26). No significant group differences in cognitive functioning were found, but the children born to mothers with substance-abuse problems showed more caregiver-reported socioemotional problems than did the low-risk children, like the children born to mothers with mental health problems. Birth weight had an effect on internalizing problems at 4½ years and mediated the relation between group and socioemotional problems, although not when controlling for caregiver education, single parenthood, and anxiety and depression. At 4½ years, 7 children born to mothers with substance-abuse problems were placed in foster care. These children had lower birth weight and higher caregiver-rated internalizing problems. In addition to emphasizing the importance of the quality of the prenatal environment, this study suggests that families with previous substance abuse are in need of long-term follow-up to address socioemotional problems and enhance further positive child cognitive development. The foster-placed children may be in particular need of long-term follow-up.

Longitudinal cognitive development of children born to mothers with opioid and polysubstance use.

BACKGROUND: Previous studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time. METHODS: The cognitive functioning of 72 children with prenatal opioid and polysubstance exposure and 58 children without any established prenatal risk was assessed at 1, 2, 3, 4½, and 8½ y. RESULTS: The exposed boys had significantly and stably lower levels of cognitive functioning than the control group, whereas there were increasing differences over time for the girls. The exposed group had significantly lower IQ scores than the control group on Wechsler Intelligence Scale for Children--Revised at 8½ y after controlling for earlier cognitive abilities, and for children who were permanently placed in adoptive/foster homes before 1 y of age and whose mothers used heroin as their main drug during pregnancy (B = 17.04, 95% CI 8.69-25.38, P < 0.001). CONCLUSION: While effects of prenatal substance exposure cannot be isolated, group effects on cognition rather increased than waned over time, even in adoptive/foster children with minimal postnatal risk.

Development of children born to mothers with mental health problems: subcortical volumes and cognitive performance at 4½ years.

In a prospective longitudinal study, we investigated the outcomes of children born to mothers clinically referred for mental health problems during pregnancy (risk group, n = 17) relative to a control group (n = 31). Child cognitive functioning, and for subgroups (n = 10 + 17), brain morphometry as derived from Magnetic resonance imaging (MRI), was measured at 4½ years. Cognitive data included abstract visuospatial reasoning/problem solving and verbal scores. Subcortical regions of interest included the amygdala, accumbens area, hippocampus, caudate and putamen, chosen because their development seems potentially sensitive to an adverse intrauterine milieu and environmental experiences, and also due to their implication in cognitive and emotional processes. The risk group exhibited poorer abstract reasoning scores than the control group. No differences were found for verbal scores. MRI revealed smaller putamen volume in children in the risk group. Irrespective of group, putamen volume was positively related to visuospatial reasoning performance. Our results suggest that maternal psychopathology may be associated with child putamen development, nonverbal reasoning and problem solving skills.

Mother-Child Interaction and Early Language Skills in Children Born to Mothers with Substance Abuse and Psychiatric Problems.

This prospective, longitudinal study with data collected at four time points investigated how maternal psychiatric symptoms, substance abuse and maternal intrusiveness in interaction were related to early child language skills. Three groups of mothers were recruited during pregnancy: One from residential treatment institutions for substance abuse (n = 18), one from psychiatric outpatient treatment (n = 22) and one from well-baby clinics (n = 30). Maternal substance abuse and anti-social and borderline personality traits were assessed during pregnancy, postpartum depression at 3 months, maternal intrusiveness in interaction at 12 months, and child language skills at 2 years. Results showed that the mothers in the substance abuse group had the lowest level of education, they were younger and they were more likely to be single mothers than the mothers in the two other groups. There was a significant difference in expressive language between children born to mothers with substance abuse problems and those born to comparison mothers, however not when controlling for maternal age, education and single parenthood. No group differences in receptive language skills were detected. Results further showed that maternal intrusiveness observed in mother-child interaction at 12 months was significantly related to child expressive language at 2 years, also when controlling for socio-demographic risk factors. This suggests that in addition to addressing substance abuse and psychiatric problems, there is a need for applying treatment models promoting sensitive caregiving, in order to enhance child expressive language skills.

Prospective fathers' adverse childhood experiences, pregnancy-related anxiety, and depression during pregnancy.

There is a growing knowledge of the predictors of depressive or anxious feelings during pregnancy among prospective fathers, and the present study investigates how paternal adverse childhood experiences relate to anxious and depressive feelings during pregnancy. Participants were recruited to "The Little in Norway Study (LIN-study)" (2010) at different well-baby clinics in Norway; 976 fathers consented to participate in the study, of which 881 had valid data for adverse childhood experiences. The study reports on the relationship between the Adverse Childhood Experience Scale (ACE Scale; R.F. Anda, A. Butchart, V.J. Felitti, & D.W. Brown, 2010) and depressive feelings, using the Edinburgh Postnatal Depression Scale (EPDS; M. Eberhard-Gran & K. Slinning, 2007), and pregnancy-related anxiety, using the Pregancy-Related Anxiety Scale-Revised (PRAQ-R; A.C. Huizink, E.J. Mulder, D.M.P.G. Robles, & G.H. Visser, 2004). Data collection was comprised of five time points during pregnancy: Time 1 (T1; Weeks 8-34) and four follow-up time points; Time 2 (T2: Weeks 20-25), Time 3 (T3: Weeks 26-31), Time 4 (T4: Weeks 32-34), and Time 5 (T5: Week 36). Fathers' with higher ACE scores reported more pregnancy-related anxiety than did fathers with lower scores at all time points in pregnancy, except at T5 (36 weeks), while also reporting more depressive feelings during pregnancy. Health providers and community centers should pay more attention to fathers' mental health during pregnancy, as the whole family system needs to be considered during pregnancy to provide optimal healthcare. Adverse childhood experiences among fathers-to-be may increase depressive and anxious feelings during pregnancy.

Attachment security in young foster children: continuity from 2 to 3 years of age.

The present study investigated attachment patterns among 60 foster children (FC) and 42 comparison children (CC) at 2 years (T1) and again at 3 years (T2) of age, as well as stability from T1 to T2. Descriptive analyses, including cross-tabulation, were used to present attachment patterns, group differences and stability from T1 to T2. Most FC were securely attached at T1, and no group differences were identified; neither the FC nor CC differed from typical children in their attachment patterns. Furthermore, the majority of children in both groups received the same classification at both time points. Among FC who were securely attached at T1, a majority remained so at T2, while among those classified as disorganized at T1, significantly less remained so at T2. The study suggests that young FC have the possibility to form enduring secure attachments when placed in stable and well-functioning foster homes.

Longitudinal development of mother-infant interaction during the first year of life among mothers with substance abuse and psychiatric problems and their infants.

The quality of mother-infant interaction during the first year may be hampered by maternal substance abuse and co-existing non-optimal factors such as psychiatric problems and difficult relational experiences. In the present study three groups of women were recruited during pregnancy: One group with substance abuse problems from residential treatment centers (n = 28), a second group from psychiatric outpatient treatment centers (n = 22), and a third group from well-baby clinics (n = 30). Four maternal optimality indexes were assessed (substance abuse, psychiatric problems, relational experiences and SES). Mother-infant interaction was observed at 3 and 12 months. The substance abuse group showed the most disturbed mother-infant interaction at 12 months. Low maternal optimality as well as impairments in maternal affective involvement at 3 months influenced negatively both on infant and dyadic affective behavior in interaction at 12 months. Long-term interventions are needed to promote affective reciprocity among mother-baby pairs with low optimality.