Detalhe da pesquisa
1.
Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies.
Bioorg Chem
; 145: 107207, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38402795
2.
New phenylthiosemicarbazide-phenoxy-1,2,3-triazole-N-phenylacetamides as dual inhibitors against α-glucosidase and PTP-1B for the treatment of type 2 diabetes.
Arch Pharm (Weinheim)
; : e2300517, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593290
3.
Novel spiro[indene-1,2'-quinazolin]-4'(3'H)-one derivatives as potent anticonvulsant agents: One-pot synthesis, in vivo biological evaluation, and molecular docking studies.
J Biochem Mol Toxicol
; 37(1): e23234, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36184906
4.
Discovery of novel 4,5-diphenyl-imidazol-α-aminophosphonate hybrids as promising anti-diabetic agents: Design, synthesis, in vitro, and in silico enzymatic studies.
Bioorg Chem
; 141: 106846, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37713948
5.
Design, synthesis, α-glucosidase inhibition, pharmacokinetic, and cytotoxic studies of new indole-carbohydrazide-phenoxy-N-phenylacetamide derivatives.
Arch Pharm (Weinheim)
; 356(6): e2200571, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017555
6.
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno[2,3-b]quinoline-hydrazones as novel inhibitors for α-glucosidase.
Bioorg Chem
; 127: 105996, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35878449
7.
Synthesis and in vitro urease inhibitory activity of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-(phenylamino)acetamides, in silico and kinetic studies.
Bioorg Chem
; 120: 105592, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121554
8.
Design, Synthesis, in Vitro, and in Silico Evaluation of N-Phenylacetamide-Oxindole-Thiosemicarbazide Hybrids as New Potential Tyrosinase Inhibitors.
Chem Biodivers
; 19(4): e202100666, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35156774
9.
New 4-phenylpiperazine-carbodithioate-N-phenylacetamide hybrids: Synthesis, in vitro and in silico evaluations against cholinesterase and α-glucosidase enzymes.
Arch Pharm (Weinheim)
; 355(5): e2100313, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35132681
10.
Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential α-glucosidase inhibitors.
J Biochem Mol Toxicol
; 35(4): e22688, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33368871
11.
Quinazolinone-dihydropyrano[3,2-b]pyran hybrids as new α-glucosidase inhibitors: Design, synthesis, enzymatic inhibition, docking study and prediction of pharmacokinetic.
Bioorg Chem
; 109: 104703, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609917
12.
Design and synthesis of 4,5-diphenyl-imidazol-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic and docking studies.
Mol Divers
; 25(2): 877-888, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32189236
13.
Design, synthesis, and α-glucosidase-inhibitory activity of phenoxy-biscoumarin-N-phenylacetamide hybrids.
Arch Pharm (Weinheim)
; 354(12): e2100179, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34467580
14.
New quinoxalin-1,3,4-oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies.
Arch Pharm (Weinheim)
; 354(9): e2000471, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33999440
15.
Novel N,N-dimethylbarbituric-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies.
Bioorg Chem
; 95: 103529, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31884139
16.
Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential α-glucosidase inhibitors.
Bioorg Chem
; 95: 103482, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31838286
17.
Synthesis of highly functionalized organic compounds through Ugi post-transformations started from propiolic acids.
Mol Divers
; 24(3): 855-887, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31325081
18.
Design and synthesis of new imidazo[1,2-b]pyrazole derivatives, in vitro α-glucosidase inhibition, kinetic and docking studies.
Mol Divers
; 24(1): 69-80, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30825061
19.
Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations.
Mol Divers
; 24(1): 179-189, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30895449
20.
New 1,2,3-triazole-(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation.
Arch Pharm (Weinheim)
; 353(9): e2000023, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32596826